granzyme B – Page 4 – Communicable Diseases Research

Histomorphological patterns of regional lymph nodes in COVID-19 lungs

COVID-19 폐에서 국소 림프절의 조직 형태학적 패턴

Main Topic: COVID-19

Published on 2021-05-052022-09-10
Journal: Der Pathologe [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients

Clinical Trial

Published on 2021-05-012022-10-05
Journal: Cell stress & chaperones [Category] SARS, 임상,

[키워드] administration anti-inflammatory effect APL cellular CIGB-258 clinical clinical trial Cohort conditions COVID-19 COVID-19 patient Critical Critically ill patient cytokine Cytokine storm decrease develop disease granzyme B Hsp60 hyperinflammation IL-10 ill patient indicated induce Inflammation intravenous Invasive mechanical ventilation Jusvinza. Ligand Necrosis Oxygen therapy Patient patients peptide Phase I Protein receiving reduced Regulatory Result rheumatoid arthritis Safe significantly specific biomarker Stress Support T cell the cytokine storm therapeutic option therapeutic potential TNF-α treated Treatment Treg Trial
[DOI] 10.1007/s12192-021-01197-2 PMC 바로가기 [Article Type] Clinical Trial

Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment

COVID-19에서 회복된 개인의 세포 면역에 대한 장기적인 영향 분석은 심각한 NKT 세포 손상을 보여줍니다

Research Article

Published on 2021-04-272022-09-10
Journal: mBio [Category] MERS, SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed caused CD4 CD4 and CD8 T cells CD8 T cell CD8 T cells Cell cell death cells cellular cellular immunity characterized Concomitant convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19-convalescent individual COVID-19-convalescent individuals cytokine Cytokines decrease defined disease expression frequencies Frequency granzyme B GzmB immune signature immune system immunological change immunological changes Impact increase in increases in individual Interaction Ki67 Ki67 expression mononuclear cell mononuclear cells NKT NKT cell pandemic Patient Peripheral blood Peripheral blood mononuclear cells proliferate reduction in Regulatory Regulatory T cell respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Significant significant decrease significantly sustained T cell T cell receptor T cells TCR the disease the patient while Wuhan
[DOI] 10.1128/mBio.00085-21 PMC 바로가기 [Article Type] Research Article

Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children – a cross-sectional observational study from southern India.

PIMS-TS, COVID-19 및 SARS-CoV2 혈청양성 아동의 혈장 바이오마커 프로파일링 - 인도 남부의 횡단면 관찰 연구.

Observational Study

Published on 2021-04-022022-08-31
Journal: EBioMedicine [Category] MERS, 바이오마커, 유전자 메커니즘, 임상,

[키워드] acute COVID-19 Analysis Biomarker Care CCL11 CCL19 CCL2 CCL20 CCL5 chemokine chemokines Chennai children Children's Hospital clinical phenotype clinical phenotypes conditions controls correlated country COVID-19 COVID-19 infection cross-sectional CRP CXCL10 cytokine Cytokine storm Cytokines elevated finding GM-CSF granzyme granzyme B growth factor Growth factors hospital Hyperinflammatory IFNα IFNβ IFNγ IL-1 IL-10 IL-15 IL-17A IL-1α IL-2 IL-33 IL-6 immune India Infection Inflammatory lymphocyte Lymphocyte count management MIS-C multiplex negative correlation paediatric inflammatory multisystem syndrome Pathogenesis performed PIMS PIMS-TS plasma biomarker positive correlation presenting pro-inflammatory cytokines SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 seropositive significantly sodium sodium levels syndrome TNFα trajectory unique VEGF
[DOI] 10.1016/j.ebiom.2021.103317 PMC 바로가기 [Article Type] Observational Study

T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19

T 세포 활성화, 고도로 무장된 세포독성 세포 및 단핵구 CD300 수용체 발현의 변화는 중증 COVID-19 환자의 특징입니다

Comparative Study

Published on 2021-03-112022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] activated Activation adaptive alteration Analysis analyzed association CD300a CD300c CD300e CD4 CD8 cells characterized Clinical characteristics clinical phenotype Clinical sign cohort of patient correlated Correlation analysis COVID-19 cytotoxic described double negative expression expression pattern flow cytometric study follicular granzyme B help HLA-DR host immune responses immature Immune cell immune system Immunopathogenesis infected with SARS-CoV-2 Laboratory low expression Mild moderate monocyte Monocytes NK cell NK cells Patient patients performed receptors severe COVID-19 severe disease severity shift T cell subset T cells
[DOI] 10.3389/fimmu.2021.655934 PMC 바로가기 [Article Type] Comparative Study

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients

점막 관련 불변 T(MAIT) 세포는 COVID-19 환자에서 고도로 활성화되고 기능적으로 손상됩니다

Article

Published on 2021-02-032022-09-01
Journal: Viruses [Category] MERS, 진단,

[키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Antiviral caused Cell cells contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 cytokine cytokine expression profile Cytokines cytolytic disease disease severity Ex vivo Express expression flow cytometry granzyme B HLA-DR IL-17A immune system Immunopathogenesis Impaired in vitro Infection lung marker measure Mild mucosal-associated invariant T (MAIT) cells Organ failure Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 perforin phenotype positively correlated progression Proinflammatory cytokine proinflammatory cytokines Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cells TNFα
[DOI] 10.3390/v13020241 PMC 바로가기 [Article Type] Article

CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS

Research

Published on 2020-11-022022-11-01
Journal: Critical Care [Category] COVID-19,

[키워드] acute respiratory distress syndrome alarmin alveolar alveolar cell ARDS ARDS patients Biomarker Bronchoalveolar lavage CCL5 CD40 ligand cell-free mitochondrial DNA clinical Concentration concentrations confounders correlated correlation COVID-19 COVID-19 ARDS patient COVID-19 ARDS patients CXCL-10 CXCL1 CXCL10 CXCL2 DNA dysregulated immune response EGF elevated epithelial lining etiology evaluated feature GM-CSF granzyme B host response IL-10 IL-1β IL-8 immune response Inflammatory inflammatory mediator involved lung mechanical ventilation mitochondrial mitochondrial DNA no difference Non-COVID-19 outcome Pathogenesis plasma predict required Result SARS-CoV-2 significantly systemic inflammation targeting Therapeutic approach TRAIL two groups unique Ventilator-free days Viral load were measured
[DOI] 10.1186/s13054-020-03328-0 PMC 바로가기 [Article Type] Research

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

바이러스 부하, 성별 및 연령에 따른 SARS-CoV-2에 대한 생체 내 항바이러스 숙주 전사 반응

Research Article

Published on 2020-09-082022-08-13
Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS,

[키워드] ACE2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age age and sex Antiviral antiviral response antiviral responses CD8A cells chemokine chemokines chemokines CXCL9 clinical manifestation clinical manifestations contribute coronavirus Course Culture cultures CXCL9 CXCR3 Cytotoxic T cell Cytotoxic T cells days post infection deficiencies deficiency demonstrated dependent on disease severity elapsed elevated examined expression Factor females Gene Expression Genes genomic granzyme B HAE Host host response host responses Host transcriptional response human airway epithelial humoral immune responses IFIT1 immune responses in vivo increase in individual induce Infection Inflammation inhibitor inhibitors interferon interferon signaling interferon-stimulated gene interferon-stimulated genes male mechanism nasopharyngeal natural killer negative controls neutrophil NF-κB nuclear OAS1 Patient PCR-confirmed populations profile Protein Proteins receptor reduced reduction in relative replicated respiratory reveal RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex shotgun shown Signaling specimen Swab T cells T helper Th1 transcript Transcription transcripts up-regulation Viral Viral load wound healing
[DOI] 10.1371/journal.pbio.3000849 PMC 바로가기 [Article Type] Research Article

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73 – Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes

Article

Published on 2020-07-222022-10-31
Journal: Cells [Category] COVID-19, SARS,

[키워드] analyzed axis CD39 CD73 CD8 cells cellular Cohort correlated COVID-19 COVID-19 patient COVID-19 patients Cytokines cytotoxic cytotoxic lymphocytes decrease disease stage expression extracellular ATP functional Future granzyme B IFN-γ immune response Immunomodulatory therapies in healthy individuals Inflammation involved lymphocyte majority natural killer Necrosis NKT NKT cell pathophysiology Patient perforin Population populations Prognostic marker purinergic signaling regulate SARS-CoV-2 secreting secretion Serum ferritin significantly higher significantly lower subset T cell target TNF-α
[DOI] 10.3390/cells9081750 PMC 바로가기 [Article Type] Article

Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

사이토톡식 T 세포 유래 그랜자임 B는 심각한 플라스모디움 팔시파룸 말라리아에서 증가한다.

Original Research

Published on 2019-12-112024-08-11
Journal: Frontiers in immunology [Category] 말라리아,

[키워드] CD8⁺ T cells granzyme B malaria Plasmodium falciparum severe malaria
[DOI] 10.3389/fimmu.2019.02917 PMC 바로가기 [Article Type] Original Research