Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritisarticle Published on 2023-06-132024-09-05 Journal: Journal of the American Society of Nephrology [Category] update2024, [키워드] clonally expanded T cells crescentic GN Cytotoxic T cells granzyme B tubular apoptosis [DOI] 10.1681/ASN.0000000000000116 PMC 바로가기 [Article Type] article
Immunodominant T cell peptides from four candidate malarial antigens as biomarkers of protective immunity against malariaArticle Published on 2023-02-032024-08-27 Journal: Vaccine [Category] 말라리아, [키워드] epitope FluoroSpot granzyme B IFN-γ malaria T cells [DOI] 10.1016/j.vaccine.2023.01.016
Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Is IFN expression by NK cells a hallmark of severe COVID-19?Research article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] 변종, 치료기술, 치료제, [키워드] addition CD107a clinical form contribute CoV COVID-19 cytolytic cytotoxic activity Cytotoxic granules decrease Defense disease elicited Express expression form Frequency Granule granzyme B groups hallmark Host IFN IFN-α IFN-γ immune responses immune system individual Innate immunity interferons involved Ki-67 Killer cell mechanism Mild natural Natural killers NK cell NK cells pathogenesis of COVID-19 PBMC PBMCs peptide pool profile question recovered COVID-19 patient reduced SARS-CoV-2 severe COVID-19 severity significant increase spike the disease the healthy viruses Volunteer [DOI] 10.1016/j.cyto.2022.155971 [Article Type] Research article
Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant어린이의 조상 SARS-CoV-2에 대한 특정 CD4+ T 세포 반응은 나이가 들어감에 따라 증가하고 베타 변이체에 대한 교차 반응성을 나타냅니다Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accompanied Activation activation induced marker (AIM) activation-induced marker activation-induced markers age ancestral Antiviral average Beta Beta variant beta variants Blood CD4+ CD4+ T cell children Control convalescent coronavirus COVID-19 cross-reactivity Cytokines cytometric disease course Effective vaccines Flow global health granzyme granzyme B HCoV Health human coronavirus human coronavirus (HCoV) IFN-γ immune response increase Infection infection rate infection rates marker Mild mononuclear cell PBMC pediatric peptide peripheral Peripheral blood Peripheral blood mononuclear cells reduced reduction response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant secreted cytokine secretion seronegative show social distancing measures Specific stimulated T cell T cell responses T cells the SARS-CoV-2 vaccination variant variant of concern (VOC) viral variant VoC was reduced were used [DOI] 10.3389/fimmu.2022.867577 PMC 바로가기 [Article Type] Article
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine1차 항체 결핍에서 SARS-CoV-2-특이적 및 기능적 세포독성 CD8 세포: 자연 감염 및 백신에 대한 반응Article Published on 2022-07-012022-09-12 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed CD107a CD8 CD8 T cell clearance Control COVID-19 COVID-19 infection COVID-19 mRNA Vaccination COVID-19 vaccine COVID19 Critical CTL CTLs CVID cytotoxic Cytotoxic T cell deficiency dose evaluated examined flow cytometry functional granzyme B healthy healthy control immunodeficiency infected cells Infection isotype control monoclonal antibody mRNA vaccine natural natural infection Patient patients with CVID Pfizer-BioNTech Pfizer/BNT vaccine primary antibody reduced reported response responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-specific CD8 T cells significantly lower subject T cell response the patient vaccination were stained X-linked agammaglobulinemia XLA XLA. [DOI] 10.1007/s10875-022-01256-y PMC 바로가기 [Article Type] Article
Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19COVID-19에 대한 CoronaVac 백신 접종 후 12개월 이내에 체액 및 세포 면역 반응의 상태Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 12 months addition antibody approved baseline binding binding and neutralizing antibodies binding antibodies binding antibody CD4 CD8 Cell Cellular immune response cellular response Cellular responses central memory CoronaVac country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical declined detectable dose effector memory Emergency use Endpoint enrolled Evidence functional gamma interferon granzyme B GzmB humoral Humoral and cellular immune responses IFN-γ IL-2 IL-5 immune memory immune persistence immune responses Inactivated vaccine interleukin interleukin 2 memory T cell memory T cells Month Neutralizing antibodies neutralizing antibody neutralizing antibody responses participant persistence produced provide RBD Receptor-binding domain reported response SARS-CoV-2 SARS-CoV-2 RBD second dose secretion seroconversion rate seropositive significantly higher status Stimulation T cells the cells the receptor-binding domain understanding vaccination vaccination schedule Vaccination strategy Vaccine [DOI] 10.1128/mbio.00181-22 PMC 바로가기 [Article Type] Article
Immunological investigation of a multiepitope peptide vaccine candidate based on main proteins of SARS-CoV-2 pathogenSARS-CoV-2 병원체의 주요 단백질에 기반한 다중 에피토프 펩타이드 백신 후보의 면역학적 조사Article Published on 2022-06-092022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] antigenic Cell complex cytotoxic T lymphocyte develop DNA E. coli Epitopes eukaryotic evaluated expression expression vectors granzyme granzyme B groups helper T lymphocyte Heterologous homologous IFN-γ IgG IgG2a IL-15 IL-21 IL-6 immune response immune responses Immunity immunized in silico in vitro in vivo indicated induce linear B linear B lymphocyte lymphocyte mammalian cell membrane protein mice multiepitope peptide vaccine multiepitope vaccine Multiepitope vaccines nucleocapsid Nucleocapsid phosphoprotein pathogen Pathogens pcDNA3.1 Penetrating peptide produced Protein regimen regimens SARS-CoV-2 SARS-COV-2 infection secretion significantly spike glycoprotein stimulated subcloned T lymphocyte target targets TNF-α Vaccine vaccine candidate variants were used [DOI] 10.1371/journal.pone.0268251 PMC 바로가기 [Article Type] Article
The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19혈청 anti-SARS-CoV-2 IgA의 존재는 COVID-19로부터 1차 의료 종사자를 보호하는 것으로 보입니다Article Published on 2022-05-012022-09-12 Journal: European Journal of Immunology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 진단, [키워드] allergy anti-SARS-CoV-2 Antibody Response appear BMI CD25 CD279 CD38 CD4+ T-cell CD69 cellular response Clinical data Contracting correlated COVID-19 CTLA-4 cytokine secretion cytotoxic Cytotoxic T cell expressing female granzyme B Health Health care worker humoral hypertension identify IFN-γ IgA IgA response IgG IgG response immune response individual Infection Male sex Neutralizing Neutralizing antibodies pandemic PCR-confirmed Primary Health Care proliferation PROTECT response SARS-CoV-2 SARS-CoV-2-specific T-cell response self-reported symptom serum serum IgG Sex smoking study population Swedish Symptoms T cell T-cell T-cell Response was used [DOI] 10.1002/eji.202149655 PMC 바로가기 [Article Type] Article