Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1현재 순환 중인 Omicron SARS-CoV-2 하위 변이체 BA.2 및 BA.1.1에 대한 인간 ACE2의 더 높은 결합 친화도의 구조적 기초Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect alteration angiotensin binding affinity binding pattern circulating complex structure complex structures contribute hACE2 highest human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction Mutation mutations omicron RBD RBDs receptor-binding domains SARS-CoV-2 SARS-CoV-2 strains strain the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1016/j.cell.2022.06.023 PMC 바로가기 [Article Type] Article
Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 micehACE2 마우스에서 항바이러스 식물화학물질에 의한 광범위한 SARS-CoV-2 변이체의 억제Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-inflammatory activity Antiviral antiviral activity antiviral drug antiviral drugs antiviral therapy attenuate Chlorella Chromatography Compound COVID-19 vaccines demonstrated Evolution Genetic Guava hACE2 host immune system in some in vivo inhibition Intervention mice new SARS-CoV-2 plant prevention of COVID-19 proinflammatory Prophylactics Psidium Region responses resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants significantly these compound these compounds Treatment Vaccine variant variants viral clearance [DOI] 10.1016/j.antiviral.2022.105371 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials동종 또는 이종 체계에서 항 SARS CoV-2 백신 SOBERANA 02의 안전성 및 면역원성: 공개 라벨 임상 1상 및 2a상 임상 시험Clinical Trial Published on 2022-07-292022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adaptive adverse event Anti-RBD IgG Antigen clinical trial clinical trials conjugate Conjugate vaccine COVID-19 COVID-19 vaccine D614G delta variant dose doses elicited ELISA evaluate evaluated frequencies Frequency hACE2 Heterologous heterologous immunization Heterologous immunization scheme homologous homologous or heterologous IgG IgG ELISA IIa immune response immune responses immunogenic immunogenicity Immunological response Interaction local pain molecular neutralization neutralized Neutralizing antibodies neutralizing antibody Open-label outcome Panel performed phase Phase I phase IIa Primary outcome progressed protocol protocols RBD receive receiving reduction reported Safe Safety SARS-CoV-2 secondary outcome selected Specific T-cell response subjects Subunit vaccine T-cell T-cell Response T-cells Tetanus tetanus toxoid trials Vaccine variant Volunteer volunteers [DOI] 10.1016/j.vaccine.2022.05.082 PMC 바로가기 [Article Type] Clinical Trial
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background miceFVB 배경 마우스에서 SARS-CoV-2 감염에 민감하고 내성이 있는 형질전환 모델 개발Article Published on 2022-07-262022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus atrophy caused Cerebellum cerebrum coronavirus 2 coronavirus disease COVID-19 COVID-19 pandemic development disease exhibited Goblet cell goblet cells hACE2 histopathological finding histopathological findings hyperplasia K18-hACE2 K18-hACE2 mice lung Lungs mice Mild mild pneumonia overcome Pneumonia reduction respiratory SARS-CoV-2 SARS-COV-2 infection sensitivities Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia small intestine spleen strain susceptibility susceptible Therapeutics transgenic mice transgenic model Vaccine viral titer weight loss White pulp [DOI] 10.1371/journal.pone.0272019 PMC 바로가기 [Article Type] Article
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodySpike S2 도메인 특이적 인간 중화 단일클론 항체의 직접적인 호흡기 투여에 의해 매개되는 강력한 보편적인 베타-코로나바이러스 치료 활성Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta acute respiratory syndrome acute respiratory syndrome coronavirus-2 Administered administration antibody Beta beta-coronavirus check conserved convalescent coronavirus coronavirus vaccine Delta demonstrated determine dose Epsilon Gamma hACE2 hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IgG Immune escape in vivo infected with SARS-CoV-2 Infection infection with SARS-CoV-2 intranasal K18 Lineage mAb mAbs MERS-CoV mice monoclonal antibody Mortality Mutation neutralize SARS-CoV neutralized Neutralizing omicron plasma potent pre-fusion Prevent Prophylactic Recognition recognize reduced respiratory respiratory viral S1 and S2 S2 domain SARS-CoV Urbani SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 significantly spike subject subjects tested therapeutic activity therapeutic potential Vaccine variants of concern Viral virus weight loss β-coronavirus [DOI] 10.1371/journal.ppat.1010691 PMC 바로가기 [Article Type] Article
DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approachDNA 앱타머는 RBD-독립적 또는 의존적 접근에 의해 hACE2에 대한 SARS-CoV-2 스파이크-단백질 결합을 억제합니다Article Published on 2022-07-182022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity anti-RBD anti-S2 Anti-spike approach aptamer best binding binding affinities binding affinity block can be used Candidates cells conserved coronavirus COVID-19 pandemic Delta develop diagnostic DNA DNA aptamer Efficacy ELISA fusion aptamer hACE2 IMPROVE independent Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction Ligand ligands linker molecular New coronavirus omicron optimization outbreak Prevent RBD recognize reported S2-protein SARS-CoV-2 selection process sequence spike-protein the RBD therapeutic variant variants were measured WT spike [DOI] 10.7150/thno.74428 PMC 바로가기 [Article Type] Article
A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug DiscoveryCOVID-19 약물 발견을 위한 잠재적인 납 화합물로서 Andrographis paniculata(Burm. f.) Nees 및 그 구성 요소에 대한 포괄적인 검토Review Published on 2022-07-132022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro activity Andrographis paniculata Anti-inflammatory anti-inflammatory activity Antiviral antiviral activity argument Asian biological properties clinical trial clinical trials Combination complementary Compound Comprehensive Constituent COVID-19 COVID-19 pandemic COVID-19 treatment Critical demonstrated drug Drug discovery early treatment economics Efficacy global health hACE2 Health immunomodulatory immunomodulatory activity in silico in vitro study Infection information ingredient inhibit lead compound Manifestations natural product pharmacological Placebo Potential Prophylaxis Randomized controlled trial Randomized controlled trials reducing review SARS-CoV-2 severity Side effects Support target protein Treatment treatment for COVID-19 upper respiratory tract upper respiratory tract infection URTI virion production Well-being [DOI] 10.3390/molecules27144479 PMC 바로가기 [Article Type] Review
Analysis of the docking property of host variants of hACE2 for SARS-CoV-2 in a large cohort대규모 코호트에서 SARS-CoV-2에 대한 hACE2의 숙주 변이체의 도킹 특성 분석Article Published on 2022-07-112022-09-11 Journal: PLoS Computational Biology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin binding free energy caused coronavirus coronavirus disease COVID-19 COVID-19 infection Diagnosis docking free energy genetic diversity genomic data global health hACE2 Health Host human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cells individual individuals Interaction large cohort missense variant Mobility molecular molecular dynamics Molecular dynamics simulation molecular interaction Novel coronavirus novel coronavirus disease outbreak physical provided receptor SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infections selected severe acute respiratory syndrome Coronavirus Spike protein subject the spike protein UK biobank variant [DOI] 10.1371/journal.pcbi.1009834 PMC 바로가기 [Article Type] Article