HCoV-229E – Page 4 – Communicable Diseases Research

Photodynamic Inactivation of Human Coronaviruses

Article

Published on 2022-01-082022-10-28
Journal: Viruses [Category] COVID-19,

Cangma Huadu granules, a new drug with great potential to treat coronavirus and influenza infections, exert its efficacy through anti-inflammatory and immune regulation

Article

Published on 2022-01-042023-06-23
Journal: Journal of ethnopharmacology [Category] 신종인플루엔자,

[키워드] BFDA, Beijing Food and Drug Administration Cangma Huadu CMHD, Cangma Huadu granules COVID-19, new coronavirus disease CPT, chloroquine phosphate tablets H1N1/FM1 HCoV-229E immunomodulation Inflammation JHQG, Jinhua Qinggan Granules LHQW, Lianhua Qingwen Granules NF-κB, Nuclear Factor kappa B PBS, phosphate buffered saline Pneumonia TCM, traditional Chinese medicine
[DOI] 10.1016/j.jep.2021.114965 PMC 바로가기 [Article Type] Article

Persistence of Anti-SARS-CoV-2 Antibodies in Long Term Care Residents Over Seven Months After Two COVID-19 Outbreaks

두 번의 COVID-19 발생 후 7개월 동안 장기 요양 시설 입소자의 항 SARS-CoV-2 항체 지속성

Immunology

Published on 2022-01-032022-09-11
Journal: Frontiers in Immunology [Category] MERS, 진단, 치료법,

[키워드] 229E Analysis Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike antibody antibody levels approved attack rate binding domain Canada Care carried changes in collected comparison COVID-19 COVID-19 outbreak cross reaction demonstrated evaluate finding Gradual HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 human coronavirus human coronavirus (HCoV) humoral humoral immune response Humoral response humoral responses individual individuals Long long term Long term care facilities median MONITOR monitors Month multiplexed immunoassay NL63 nucleocapsid OC43 outbreak Outbreak investigation outbreak investigations Outbreaks over participant participated performed platform provided public health RBD reaction Receptor binding domain Reinfection resident SARS-CoV-2 serologic test serologic testing serologic tests serological serological survey Serological surveys seronegative seropositive seropositive individual serostatus serum serum sample serum samples Seven Spike protein Spike proteins statistical analyses statistically significant survey term the spike protein were used
[DOI] 10.3389/fimmu.2021.775420 PMC 바로가기 [Article Type] Immunology

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

Short Reports

Published on 2021-12-282022-10-28
Journal: PLoS Biology [Category] COVID-19, SARS,

[키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses
[DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports

Computational study, synthesis and evaluation of active peptides derived from Parasporin-2 and spike protein from Alphacoronavirus against colorectal cancer cells

Cancer

Published on 2021-12-222022-10-28
Journal: Bioscience Reports [Category] Coronavirus,

Nanoformulation Composed of Ellagic Acid and Functionalized Zinc Oxide Nanoparticles Inactivates DNA and RNA Viruses

Article

Published on 2021-12-162022-10-28
Journal: Pharmaceutics [Category] COVID-19,

Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action

Article

Published on 2021-12-112023-07-01
Journal: Phytomedicine : international journal of phytother [Category] SARS,

[키워드] Anti-inflammatory Antiviral CC₅₀, 50% cytotoxicity concentration CCCP, carbonyl cyanide m-chlorophenylhydrazone Coronaviruses COVID-19, Coronavirus disease 2019 CPE, cytopathic effect cytC, cytochrome c DMEM, Dulbecco's modified Eagle's medium DMSO, dimethyl sulfoxide EC₅₀, half maximal effective concentration FBS, fetal bovine serum G-CSF, granulocyte colony-stimulating factor GAPDH, glyceraldehyde 3-phosphate dehydrogenase HCoV-229E HCoV-229E, human coronavirus 229E Huh-7, hepatocellular carcinoma cell line IC₅₀, 50% inhibition concentrations IL-1β, interleukin-1beta IL-6, Interleukin-6 IP-10, Interferon-inducible protein-10 Jinzhen granule JZ, Jinzhen granule MAPK, mitogen activated protein kinase MCP-1, Monocyte chemoattracctant protein-1 MERS-CoV, Middle East respiratory syndrome coronavirus MIP-1a, Recombinant Macrophage Inflammatory Protein 1 Alpha MOI, multiplicity of infection NF-κB, nuclear transcription factor-kappa B NHP, nonhuman primates animal model PARP, poly (ADP-ribose) polymerase PBS, phosphate-buffered saline PFU, plaque forming-unit RT-qPCR, Real-time Fluorescent Quantitative Polymerase Chain Reaction SARS-CoV-2 SARS-CoV, severe acute respiratory syndrome coronavirus SI, selective index TCID₅₀, 50% tissue culture infective dose TCM, traditional Chinese medicine TNF-α, tumor necrosis factor-α Vero E6, African green monkey kidney epithelial cell line VGM, virus growth medium
[DOI] 10.1016/j.phymed.2021.153874 PMC 바로가기 [Article Type] Article

Antiviral Activity of the Rhamnolipids Mixture from the Antarctic Bacterium Pseudomonas gessardii M15 against Herpes Simplex Viruses and Coronaviruses

Article

Published on 2021-12-082022-10-28
Journal: Pharmaceutics [Category] COVID-19,

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다

Research Article

Published on 2021-11-222022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus viruses zoonotic origin
[DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study