Total antioxidant capacity as a marker of severity of COVID-19 infection: Possible prognostic and therapeutic clinical applicationCOVID-19 감염의 중증도 마커로서의 총 항산화 용량 : 가능한 예후 및 치료 임상 적용Article Published on 2022-04-012022-08-31 Journal: Journal of medical virology [Category] 바이오마커, [키워드] activity antioxidant antioxidant enzyme blood sample Blood samples catalase causative pathogen collected Concentration control group COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity Defense dismutase Enzymes healthy individual healthy individuals healthy volunteer infected individual infected individuals Infection investigated marker Mild Mild disease nitric oxide oxidative stress Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 Predictive prognostic Research SARS-COV-2 infection sera serum serum levels severe disease severely ill patients severity of COVID-19 statistically significant Superoxide Superoxide Dismutase susceptible TAC therapeutic Total total antioxidant capacity Variation was performed were measured with mild disease [DOI] 10.1002/jmv.27500 PMC 바로가기 [Article Type] Article
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article
SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity특정 체액 면역이 없는 1차 항체 결핍 환자의 중증 및 치명적인 COVID-19에서 SARS-CoV-2 T 세포 반응Article Published on 2022-03-102022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Analysis analyzed antibody autoantibodies autoantibody Blood CD169 CD4 cellular characterized clearance clinical disease Comorbidities Comorbidity convalescent convalescent plasma Convalescent plasma (CP) coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 cytokine deficiency detectable elevated examined excluded expression fatal COVID-19 flow cytometry healthy individuals heterogeneous humoral humoral immune response IgG Immunity immunodeficiency immunological immunological mechanism Inborn errors indicate innate immune response Innate immunity interferon interferons lack marker median monoclonal antibody Monocytes morbidity Mortality mucosal naïve nucleocapsid outcome Patient patients peptide peptide pool Peripheral blood persistence phenotype primary antibody primary antibody deficiency (PAD) Primary immunodeficiencies primary immunodeficiencies (PID) producing Prophylactic respiratory response Risk factors robust SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 viral shedding seronegative severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severe case severe cases severe COVID-19 patient SIGLEC1 Specific T cell T cell response T cells Treatment type I interferon type I interferon response type I interferons undetectable Viral viral clearance viral shedding with COVID-19 [DOI] 10.3389/fimmu.2022.840126 PMC 바로가기 [Article Type] Article
An artificial intelligence deep learning platform achieves high diagnostic accuracy for Covid-19 pneumonia by reading chest X-ray imagesResearch article Published on 2022-03-072022-10-05 Journal: iScience [Category] 비임상, 진단, 치료기술, [키워드] Accuracy analyzed artificial intelligence Bacterial build cause caused Chest X-ray image Chest X-ray images Clinical diagnosis clinical feature coronavirus disease COVID-19 pneumonia Critical deep learning Deep Learning Method detect develop diagnostic healthy individuals lung Lung infection organism Patient platform Pneumonia radiology RNA severity the disease Treatment Viral pneumonia Virology X-ray [DOI] 10.1016/j.isci.2022.104031 [Article Type] Research article
Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19Research article Published on 2022-03-022022-10-05 Journal: Blood advances [Category] 바이오마커, 유전자 메커니즘, 임상, [키워드] 24 hour activated Activation acute respiratory syndrome age Biomarker changes Clinical outcome clinical outcomes clinically Coagulation collected complexes Computed tomography Contact contribute Control coronavirus COVID-19 COVID-19 diagnosis demonstrated disease severity enrolled enzyme-linked immunosorbent extrinsic extrinsic pathway healthy individuals Hospitalization implicated increasingly individuals with COVID-19 Infection inflammatory conditions inhibitor Inpatient intensive care intrinsic intrinsic pathway lung occur Pathogenesis pathway Pathways patients with COVID-19 plasma Prospective Study prothrombotic state required Sample tissue was measured were measured with COVID-19 [DOI] 10.1182/bloodadvances.2021006620 [Article Type] Research article
Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study안지오텐신전환효소 삽입/제거 다형성, ACE 활성, 그리고 코로나19: 다소 논란의 여지가 있는 가설. 사례 대조 연구Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 유전자 메커니즘, [키워드] ACE ACE activity ACE inhibitor ACE inhibitors ACE polymorphism allele alleles Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme. Angiotensin receptor blockers Angiotensin-converting enzyme arbitrary units carrier case-control study characterized complex conducted Control controls COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease severity enzyme epidemiological data expressed First wave Generalized linear model Genotype genotypes healthy individual healthy individuals Hypothesis I/D genotype increased risk individuals insertion insertion/deletion limit mechanism Patient Poisson regression polymorphism Prevalence recruited reduction Renin renin-angiotensin system retrospective risk factor risk ratio risk ratios RRs SARS-CoV-2 severe disease severity shown synergy therapy was used [DOI] 10.1002/jmv.27417 PMC 바로가기 [Article Type] Article
Major trace elements and their binding proteins in the early phase of Covid-19 infection코로나19 감염 초기의 주요 미량원소와 결합단백질Article Published on 2022-03-012022-09-11 Journal: Journal of biological inorganic chemistry : JBIC : [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 2019 albumin Alpha Alpha-2-macroglobulin binding cellular changes in circulating circulation Concentration contribute copper coronavirus disease correlated correlation correlations COVID-19 Defense defense mechanisms distribution early phase early stage followed by form greater healthy healthy individuals Immunoblot analysis in some Increased infected individuals Infection Ion iron macroglobulin Major mechanism metal metal ions molecular monomer Novel coronavirus novel coronavirus disease participant Pathogenesis Patient Prognostic marker Prognostic markers Protein proteinase therapeutic Trace element upper reference limit was measured Zinc zinc ion zinc supplementation [DOI] 10.1007/s00775-022-01931-w PMC 바로가기 [Article Type] Article
COVID-19 vaccination in cancer patients: a narrative review암 환자의 COVID-19 예방 접종: 내러티브 검토Review Published on 2022-03-012022-09-12 Journal: The Journal of international medical research [Category] MERS, SARS, 진단, [키워드] active cancer acute respiratory syndrome adverse effect affected article Cancer caused cell-mediated immune response comparable coronavirus Coronavirus disease 2019 COVID COVID-19 COVID-19 vaccination COVID-19 vaccine database disease severity Effectiveness Factor Google Scholar haematological malignancies healthy individuals humoral humoral immune response immunogenicity in healthy individuals individual interval investigated knowledge morbidity and mortality Mortality Patient Patients with cancer profile reducing SARS-CoV-2 second dose shown solid cancers solid malignancies vaccination Vaccine vaccine dose vaccine effectiveness vaccine response vaccine safety Vaccines [DOI] 10.1177/03000605221086155 PMC 바로가기 [Article Type] Review
Cardiac involvement in patients recovered from COVID-19 identified using left ventricular longitudinal strain좌심실 세로 변형을 사용하여 확인된 COVID-19에서 회복된 환자의 심장 침범Article Published on 2022-03-012022-09-11 Journal: Journal of echocardiography [Category] SARS, 치료기술, [키워드] abnormality acute phase both groups cardiac control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients deformation demographic detect diagnostic echocardiographic parameter echocardiographic parameters echocardiography edema evaluate GLS healthy individuals hospitalized patients in both groups left LVEF median myocardial damage Myocardial dysfunction myocardial involvement Patient question recovered reduced reduction in strain the disease ventricular ventricular ejection was performed [DOI] 10.1007/s12574-021-00555-4 PMC 바로가기 [Article Type] Article
High Serum Progranulin Levels in COVID-19 Patients: A Pilot StudyCOVID-19 환자의 높은 혈청 프로그래뉼린 수치: 파일럿 연구Article Published on 2022-03-012022-09-11 Journal: Biochemistry. Biokhimiia [Category] MERS, 바이오마커, [키워드] All participants ALT AST Asymptomatic AUC Biomarker can be used Concentration control group Course COVID-19 COVID-19 disease CRP determinant determine Diagnosis ELISA kits evaluate examined healthy individual healthy individuals IL-6 infected with COVID-19 Level moderate participant Patient patients PCT predict Prognosis progranulin ROC analysis serum severity statistically the disease the patient TNF-α was performed WBC were measured [DOI] 10.1134/S0006297922030026 PMC 바로가기 [Article Type] Article