hemophagocytic lymphohistiocytosis – Page 4 – Communicable Diseases Research

Systemic Lupus Erythematosus With Hemophagocytic Lymphohistiocytosis: Is COVID-19 the Inciting Factor?

Infectious Disease

Published on 2021-11-172022-10-31
Journal: Cureus [Category] COVID-19,

The Spectrum of Manifestations of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) Infection in Children: What We Can Learn From Multisystem Inflammatory Syndrome in Children (MIS-C)

Medicine

Published on 2021-10-282022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] absence acute SARS-CoV-2 infection ADE antibody Asymptomatic carrier Can capillary cardiac function children children with MIS-C clinically collected coronavirus disease 19 COVID-19 Critical defined definitive diagnosis develop disease etiology Evidence feature Fever heart failure hemodynamic hemophagocytic lymphohistiocytosis HLH Hospitalization hyperinflammation Hyperinflammatory immunological immunological profile Infection Inflammatory biomarker Inflammatory response Interpretation Isolation Laboratory manifestation mechanism MIS-C molecular Myocardial inflammation myocarditis observation occur organ Pathogenesis Patient patients pediatric positive serology preserved profiles respiratory responsible SARS-CoV2 SARSCoV-2 Severe infection Shock Spectrum symptomatic syndrome the disease toxic TSS Viral load
[DOI] 10.3389/fmed.2021.747190 PMC 바로가기 [Article Type] Medicine

Discrimination of COVID-19 From Inflammation-Induced Cytokine Storm Syndromes Using Disease-Related Blood Biomarkers

질병 관련 혈액 바이오마커를 사용한 염증 유발 사이토카인 폭풍 증후군과 COVID-19의 구별

Article

Published on 2021-10-012022-09-11
Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] 바이오마커,

[키워드] Activation Adhesion Molecule association Biomarker Biomarkers Characteristics classic condition correlation correlations Course COVID-19 Critical cytokine Cytokine storm discrimination disease drugs targeting dysregulation Efficacy enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls hemophagocytic lymphohistiocytosis high mortality HLH hyperinflammation IL-1 IL-1 receptor antagonist IL-8 immune activation immune dysregulation intercellular intercellular adhesion molecule interferon interleukin Interleukin-18 Level longitudinal samples Macrophage macrophage activation syndrome measurement Novel coronavirus novel coronavirus SARS-CoV-2 observation occur outcome pathway Pathways Patient patients patients with COVID-19 performed profile quantified receptor antagonist reduced SARS-COV-2 infection secondary hemophagocytic lymphohistiocytosis Serum level serum levels serum sample serum samples severe COVID-19 soluble Fas ligand storm subgroup of patients systemic cytokine systemic hyperinflammation thought Treatment treatment of COVID-19 Trigger triggers were assessed
[DOI] 10.1002/art.41763 PMC 바로가기 [Article Type] Article

Cytokine storm in severe COVID-19 pneumonia

심각한 COVID-19 폐렴의 사이토카인 폭풍

Article

Published on 2021-09-012022-09-11
Journal: Journal of medical virology [Category] SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome addition Alanine ALT Anemia anti-cytokine anti-cytokine therapy ARDS aspartate AST clinic Confirmed COVID-19 infection coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 pneumonia criteria Cytokine storm decrease determine develop disease elevated elevated lactate dehydrogenase feature ferritin help hemoglobin hemophagocytic lymphohistiocytosis Hospitalized Hyperferritinemia hyperfibrinogenemia Hyperinflammatory syndrome ICU ICU admission identify immnopathology immune immune responses in some include Inflammation intensive care intensive care unit Laboratory laboratory parameter Laboratory parameters Lactate lactate dehydrogenase LDH leukocyte Liver function Liver function test lymphocyte lymphocytopenia Macrophage macrophage activation syndrome Novel coronavirus occurred parameter parameters Patient patients Planning Platelet Pneumonia predict procalcitonin progression reduced respiratory distress Respiratory distress syndrome retrospective cohort study secondary hemophagocytic lymphohistiocytosis Severe COVID-19 pneumonia Severe patient severe pneumonia sHLH significant changes in significantly significantly increased Symptom syndrome the cytokine storm the patient thrombocytopenia transferred Triglyceride troponin two subgroups virus virus classification with COVID-19 worsened worsening
[DOI] 10.1002/jmv.27068 PMC 바로가기 [Article Type] Article

Secondary Hemophagocytic Lymphohistiocytosis in Post-COVID-19 Patients: A Report of Two Cases

Infectious Disease

Published on 2021-08-202022-10-31
Journal: Cureus [Category] COVID-19,

Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019

코로나바이러스 질병 2019와 관련된 소아 다기관 염증 증후군의 면역학적 평가

Article

Published on 2021-08-142022-09-11
Journal: Journal of the Pediatric Infectious Diseases Socie [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis anatomical compartment assessment caused Cell Chain Reaction children coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine profile Cytokines degranulation Elevation enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of expression feature Fever functional Genetic Geneva University Hospital Geneva University Hospitals hemophagocytic lymphohistiocytosis HLH host-pathogen interactions humoral IgA IgG immunofluorescence Immunoglobulin immunoglobulin A Immunoglobulin G immunological immunological and virological workup infection with SARS-CoV-2 Inflammation Inflammatory Laboratory marker mechanism MIS-C multisystem inflammatory syndrome in children natural killer negative Neutralizing antibodies neutralizing antibody pathophysiology Patient Pediatric patient perforin persistent fever phenotypic overlap polymerase chain polymerase chain reaction positive positive serology Postinfectious postinfectious syndrome receptor reported respiratory RT-PCR RT-PCRs SARS-CoV-2 severe COVID-19 Severity of disease syndrome T-cell activation Virological virus neutralization assay was performed
[DOI] 10.1093/jpids/piaa142 PMC 바로가기 [Article Type] Article

Identifying organ dysfunction trajectory-based subphenotypes in critically ill patients with COVID-19

COVID-19 중환자의 장기 기능 장애 궤적 기반 하위 표현형 식별

Article

Published on 2021-08-052022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] assessment baseline Biomarker Central nervous system Clustering Coagulation COVID-19 COVID-19 patient Critical Critical illness Critically ill patient defined detect dynamic dysfunction evaluate evaluated failure hemophagocytic lymphohistiocytosis heterogeneous hospital host response identify identifying Inflammation Intubated Intubated COVID-19 patients intubation liver measure Mild Mortality New York New York City offer organ dysfunction organ systems outcome pathogenic pathophysiology Predictive Prognosis progression renal Respiration respiratory Respiratory failure Sequential Organ Failure Assessment severe COVID-19 severity severity of illness similarities similarity SOFA SOFA score time trajectory understanding validation cohorts viral infection was performed with COVID-19 worsening
[DOI] 10.1038/s41598-021-95431-7 PMC 바로가기 [Article Type] Article

Incidence of Secondary Hemophagocytic Lymphohistiocytosis in Critically-Ill COVID-19 Patients

Internal Medicine

Published on 2021-07-292022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory distress adult respiratory distress syndrome age All study participant Analysis average closely resemble Coronavirus disease 2019 COVID-19 COVID-19 infected patients COVID-19 patient COVID-19 positive patient Critically ill death described determine diagnosed Diagnosis Diagnostic Criteria FIVE greater hemophagocytic lymphohistiocytosis incidence incidence and prognosis inclusion criteria inflammatory storm Invasive mechanical ventilation Lung injury male measurement mechanical ventilation multi-viral pneumonia Non-COVID-19 objective parameters Patient positive COVID-19 positive patients receiving reported Result Retrospective studies Retrospective study sars-cov-2 (severe acute respiratory syndrome coronavirus -2) secondary secondary hemophagocytic lymphohistiocytosis Sepsis setting severe respiratory distress syndrome sHLH Standard deviation subsequent syndrome USA was determined were excluded
[DOI] 10.7759/cureus.16735 PMC 바로가기 [Article Type] Internal Medicine

The Perfect Cytokine Storm: Utilization of Lung Ultrasound During Urgent Surgery in an Infant With Multisystem Inflammatory Syndrome in Children and Hemophagocytic Lymphohistiocytosis

Anesthesiology

Published on 2021-06-142022-10-31
Journal: Cureus [Category] COVID-19,

Hemophagocytic lymphohistiocytosis after COVID-19 vaccination

Letter to the Editor

Published on 2021-06-042022-10-29
Journal: Journal of Hematology & Oncology [Category] COVID-19, MERS, SARS,

[키워드] Acetate activated macrophage Bone marrow caused Chinese Coagulopathy coronavirus disease COVID-19 COVID-19 vaccination Critical Cytotoxic T cells cytotoxicity Dexamethasone discharged disorder DNA EBV elevated Epstein–Barr virus Epstein–Barr virus Fever fibrinogen first dose healthy hemoglobin hemophagocytic lymphohistiocytosis HLH Hyperinflammatory syndrome inactivated indicate Infection initial laboratory result life-threatening malaise multiple organ failure neutrophil count NK cell Platelet Positive test receiving reported resolved SARS-CoV-2 vaccine serum ferritin level SIGN the patient thrombotic Triglyceride Vaccine virus vomiting
[DOI] 10.1186/s13045-021-01100-7 PMC 바로가기 [Article Type] Letter to the Editor