Genetic Analysis of Avian Coronavirus Infectious Bronchitis Virus in Yellow Chickens in Southern China over the Past Decade: Revealing the Changes of Genetic Diversity, Dominant Genotypes, and Selection PressureArticle Published on 2019-09-262022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Amino acid Analysis ancestor Bayesian change changed chicken China circulating decrease Diversity dominant Entropy Evolutionary rate Genetic genetic diversity Genotype genotypes high mutation rate IBV Infectious Bronchitis Virus insertion isolate isolates molecular molecular evolutionary rate N gene Phylogenetic tree Positive selection pressure Proteins Purifying recombinants Recombination Selection selection pressure strain threat urgency Vaccine Variation virus yellow [DOI] 10.3390/v11100898 PMC 바로가기 [Article Type] Article
Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV환자 내 돌연변이 빈도는 CpG 디뉴클레오티드의 적합성 비용과 HIV의 급격한 아미노산 변화를 나타냅니다.Research Article Published on 2018-06-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Amino acid amino acid change amino acid changes approach calculated contribute costly CpG determine dinucleotide distribution drastic Evolution Evolvability expected Factor Frequency help high mutation rate HIV host’s immune system in vivo lead mean frequency microbes mutant mutant frequencies Mutation mutation rate mutations Non-synonymous Non-synonymous mutation nonsense mutation Nonsense mutations patients Population power predict reduce replicate synonymous the mean transition mutation transition mutations Trigger variety Viral viral fitness virus [DOI] 10.1371/journal.pgen.1007420 PMC 바로가기 [Article Type] Research Article
Receptor-binding loops in alphacoronavirus adaptation and evolutionArticle Published on 2017-11-232022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] accompanied aminopeptidase N Analysis APN buffer characterized complex coronavirus ectodomain Evolution extended loop HCoV-229E high mutation rate IMPROVE interactions Mutation neutralizing antibody random RBD receptor Receptor binding replaced responsible RNA virus the mean the RBD the receptor-binding domain Variation viral fitness virus X-ray [DOI] 10.1038/s41467-017-01706-x PMC 바로가기 [Article Type] Article
Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential TherapeuticsResearch Article Published on 2013-08-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 5-FU activity antiviral activity antiviral drug Author biochemical Combination compared conserved coronavirus CoV CoV replication CoVs Critical decrease demonstrated determine Epidemic Evidence Exoribonuclease Express Genetic high mutation rate human coronavirus human disease Hypothesis identify increase in inhibitor inhibitory activity lethal MERS-CoV Middle East Mutagenesis Mutation Next-generation sequencing NO nonstructural protein 14 nsp14-ExoN nucleotides Population Potential Prevent Probability Proofreading provide RdRP Replication required respiratory responsible ribavirin RNA RNA synthesis RNA virus SARS-CoV selective sensitivity severe Support susceptible target Therapeutics to define treated Vaccine viral adaptation Viral protein viral RNA synthesis virus virus replication while wild-type zoonotic [DOI] 10.1371/journal.ppat.1003565 PMC 바로가기 [Article Type] Research Article
The Role of Viral Population Diversity in Adaptation of Bovine Coronavirus to New Host EnvironmentsResearch Article Published on 2013-01-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adaptation amplified arginine residues average coverage binding bovine Bovine coronavirus cell type coded consensus sequence coronavirus Coronaviruses de novo mutation deep deep sequencing different Diversity Environment events fixation Frequency Genetic genetic diversity Genome genomic change Genotype high mutation rate Host host cells Hypothesis indicated infect Infected Infection lung cell line lung cell lines Macrophage macrophages Multiple Mutation Nasal sample New nucleotide occurred Pathogens Point mutation Population quasispecy respond RNA virus role selective pressure sequenced Sequencing spike gene strain subsequent Support virus was used were used [DOI] 10.1371/journal.pone.0052752 PMC 바로가기 [Article Type] Research Article