Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balanceH3K9 메틸화 균형을 조절하여 H3K9 탈메틸화효소 Jmjd1a 결핍 마우스의 비정상적인 성 발달 구조Research Article Published on 2017-09-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity administration approach balance biological function Cancer chromatin complex core histones deficiency demethylase demonstrated Diseases DNA Embryo embryonic enzyme Epigenetic eukaryotes expression Genetic hallmark heterochromatin heterozygous histone histone methylation Histones inhibitor initiate intellectual disability leads locus lysine mammals Methylation methyltransferase mice Modification modulating modulation molecular mechanism mutant Mutation pharmacological phenotype principle proof provide rescued reveal Sex Sex determination Therapeutic strategies therapeutic strategy transcriptional regulation transcriptionally tuning [DOI] 10.1371/journal.pgen.1007034 PMC 바로가기 [Article Type] Research Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article