Potential of Marine Terpenoids against SARS-CoV-2: An In Silico Drug Development ApproachArticle Published on 2021-10-202022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] 3CL pro acute respiratory syndrome addition analysed Analysis anti-SARS-CoV-2 Antiviral antiviral drug computational tool Coronavirus-2 develop development docking score drug enzyme exhibited Favipiravir genomic HSV-1 in silico Infection M pro marine terpenoids molecular docking performed pharmacological Phylogenetic tree Potential protease RdRP Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 strain selected sequence shown terpenoid toxicity and drug−likeness profiles [DOI] 10.3390/biomedicines9111505 PMC 바로가기 [Article Type] Article
Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung CellsCommunication Published on 2021-09-262022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 229E acid added affected Antiviral antiviral activity Antiviral compound caused coronavirus Coronaviruses COVID-19 pandemic CPE Cytopathic effect deaths demonstrated disrupting Ebola effective effective antiviral treatment Efficacy epithelial Epstein Barr virus exhibited expression fusion inhibitor ginkgolic acid globe HCoV-229E Herpe HIV HSV-1 Human human coronavirus in vitro in vivo individual Infection influenza A inhibit inhibited inhibiting lung cell Post-infection progeny Proteins reduced reported SARS-CoV-2 significantly similarity strain Vaccine Viral mutations Viral protein Viral proteins virus production viruses [DOI] 10.3390/ph14100980 PMC 바로가기 [Article Type] Communication
Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICUICU에 입원한 COVID-19 환자의 스페인 코호트에서 손상된 항체 의존성 세포 세포 독성Observational Study Published on 2021-09-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] analysed antibody antibody-dependent cell-mediated cytotoxicity antibody-dependent cellular cytotoxicity (ADCC) B cell B cells cause Cell-mediated cytotoxicity Clinical management CMV CMV reactivation COVID-19 COVID-19 severity Critical Critical disease critical patient critical patients cytotoxicity detectable EBV EBV reactivation elicited enhanced Gender herpesvirus Hospitalization Hospitalized HSV-1 humoral immune response Humoral response ICU IgG level immune response immunologic response immunologic responses Impaired individuals levels of antibody male memory Mild mild patient mild patients neutralization ability outcomes pandemic parameter Patient Phenotypes plasma recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies severe disease Severe patient severe patients significantly Spain Spanish subjects symptomatic Viremia [DOI] 10.3389/fimmu.2021.742631 PMC 바로가기 [Article Type] Observational Study
Enhanced Antiviral Function of Magnesium Chloride-Modified Heparin on a Broad Spectrum of VirusesArticle Published on 2021-09-172022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Adenovirus Analysis Antiviral Antiviral effect conformational change coronavirus decrease enhanced function heparin herpes simplex HSV-1 immortalized infected cell investigated Magnesium magnesium chloride modified heparin NMR nuclear magnetic resonance previous study primary cells Replication reported SARS-CoV-2 significantly Spectrum supernatant tested Viral load virus virus growth [DOI] 10.3390/ijms221810075 PMC 바로가기 [Article Type] Article
Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future TherapeuticsReview Published on 2021-09-172024-09-02 Journal: Viruses [Category] 대상포진, [키워드] Antiviral strategies host-virus interaction HSV-1 Viral immune evasion viral replication and pathogenesis virus [DOI] 10.3390/v13091856 PMC 바로가기 [Article Type] Review
Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational StudyArticle Published on 2021-09-072022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Herpesviridae association clinical manifestation clinically Co-infection conducted consecutive patient detectable Encephalitis event Evidence Hepatitis Herpe herpes labialis High dose Hospitalized hospitalized COVID-19 patients HSV-1 IMV incidence increased risk Infection LDH Logistic regression analysis manifestation mechanical ventilation Modena Odds ratio participant Patient patients patients with COVID-19 patients with SARS-CoV-2 PCR plasma Pneumonia positive patient Prospective re-activation SARS-CoV-2 SARS-CoV-2 pneumonia severe pneumonia significantly simplex single-center study steroid steroid treatment Steroids Support tested The effect size Tocilizumab treated use of steroid Viremia [DOI] 10.3390/microorganisms9091896 PMC 바로가기 [Article Type] Article
Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2Review Published on 2021-07-312022-11-01 Journal: Foods [Category] COVID-19, [키워드] 3CL pro ACE2 acute respiratory syndrome addition amino acid residue angiotensin-converting enzyme 2 Anti-inflammatory anticancer antioxidant Antiviral antiviral properties binding affinity Characteristics Chemical chemical constituents clinical Clinical applications component coronavirus COVID-19 demonstrated derivative dietary supplement distribution Diversity drug-likeness effective Efficacy Helicase herpes simplex high affinity HIV HSV-1 Human immunodeficiency virus Hydrogen bond immunomodulatory influenza viruses measure metabolism modulating molecular docking Molecular docking study over Papain-like protease parameters pathogenic Pathways Potential Preclinical produced property Propolis protease RBD RdRP respiratory tract RNA-dependent RNA polymerase S-protein SARS-CoV-2 SARS-CoV-2 proteins shown Support target proteins the receptor-binding domain the spike protein therapeutic these compounds Toxicity viral entry virus viruses [DOI] 10.3390/foods10081776 PMC 바로가기 [Article Type] Review
Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex VirusAntiviral Agents Published on 2021-07-062024-09-04 Journal: Med Instrum [Category] 대상포진, [키워드] amenamevir Antiviral agents Helicase-primase complex HSV-1 HSV-2 UL5 UL52 [DOI] 10.1128/AAC.00494-21 PMC 바로가기 [Article Type] Antiviral Agents
Hypopharyngeal Ulcers in COVID-19: Histopathological and Virological Analyses – A Case ReportCOVID-19의 하인두 궤양: 조직병리학적 및 바이러스학적 분석 – 사례 보고서Case Reports Published on 2021-07-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Analysis Autopsy bowel can not CD68 cells Cells expressing composed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA esophagus excluded FIBRIN foci gastrointestinal tract GI Tract Hemorrhagic herpes simplex herpes simplex virus Herpes Simplex Virus 1 Histopathologic analysis histopathological Histopathology HSV HSV-1 hypopharynx immunohistochemistry infiltration Inflammation Inflammatory involved lesion Local microthrombi molecular molecular analysis mucosal mucosal injury muscle fibers Necrosis negativity oral cavity oropharynx Perspective pharyngeal Platelet positive cells posterior walls producing question report reported respiratory RNA SARS-CoV-2 SARS-CoV-2 spike Severe acute respiratory syndrome Skeletal muscle stomach subunit supported ulcer ulcerative ulcerative lesions virus viruses [DOI] 10.3389/fimmu.2021.676828 PMC 바로가기 [Article Type] Case Reports
Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies면역 조절 요법 후 COVID-19 환자에서 HSV-1 감염으로 인한 급성 간부전의 2건의 치명적인 사례Article Published on 2021-07-012022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute liver failure clinical consequences corticosteroid therapy COVID-19 COVID-19 patients herpes simplex HSV-1 immunomodulatory Infection liver failure patients Screening Tocilizumab Treatment virus [DOI] 10.1093/cid/ciaa1246 PMC 바로가기 [Article Type] Article