human ACE2 – Page 4 – Communicable Diseases Research

Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection

다양한 인간 집단의 인간 ACE2 다형성이 SARS-CoV-2 감염을 조절합니다

Article

Published on 2022-06-302022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication VoC VOCs zoonotic
[DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article

A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection

스파이크와 뉴클레오캡시드를 발현하는 변형된 백시니아 앙카라 백신은 SARS-CoV-2 Delta 감염으로부터 붉은털 원숭이를 보호합니다

Article

Published on 2022-06-242022-09-11
Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] added Beta Beta variant binding Blood CD4 CD8 T cell correlated cross-reactive cross-reactive antibody Delta delta variant Efficacy elicited expressed expressing FCS function furin furin cleavage site Heterologous homologous human ACE2 humoral IgG inactivated inactivation induce Infection intramuscular less lung mice moderate neutralized Neutralizing Neutralizing antibodies neutralizing antibody non-neutralizing antibody nose nucleocapsid positively correlated PROTECT rectum response rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccines secretion serum spike spike-specific IgG T cell T cell response T cell responses tested the SARS-CoV-2 vaccination Vaccine variant variants of concern virus VoC VOCs
[DOI] 10.1126/sciimmunol.abo0226 PMC 바로가기 [Article Type] Article

A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants

ACE2 및 TMPRSS2를 발현하는 새로 설계된 A549 세포주는 Delta 및 Omicron 변이체를 포함하여 SARS-CoV-2에 매우 관대합니다.

Article

Published on 2022-06-232022-09-11
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] A549 A549 cell A549 cells ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antivirals breakthrough infections can be used Cell coronavirus Critical Culture Delta delta and omicron variants drugs EIDD-1931 Express expressed expressing Factor Host human ACE2 human cell identify Including Infection infection with SARS-CoV-2 inhibit SARS-CoV-2 lack LINE nelfinavir New Nirmatrelvir omicron Omicron variants Permissive Remdesivir respiratory Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serine severe acute respiratory syndrome Coronavirus Spike protein susceptible the SARS-CoV-2 TMPRSS2 transcript transducing transmembrane serine protease transmembrane serine protease 2 variant Viral viral entry virus infections
[DOI] 10.3390/v14071369 PMC 바로가기 [Article Type] Article

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

조작된 ACE2 미끼는 SARS-CoV-2 Omicron 변이체를 중화하고 생체 내 감염으로부터 보호합니다.

Article

Published on 2022-06-222022-09-11
Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] ACE2 Alpha alpha and delta variants Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 BNT162b2 breakthrough infections Casirivimab chimeric Complete conserved conserved region contributed convalescent serum deep delta variant Delta variants demonstrated dose drugs effective enzyme escape escaped evade exhibited Frequency hamster hamsters human ACE2 Imdevimab immunized in vivo individual Infection multiple mutation multiple mutations Mutation N-terminal domain neutralization neutralization titer neutralize neutralized of BNT162b2 omicron parental prevented pseudo-virus raising Receptor binding domain sarbecovirus SARS-CoV-2 variant SARS-CoV-2 variants sensitivity serum serum sample serum samples Sotrovimab Spike protein Spike proteins target the SARS-CoV-2 the spike protein theory therapeutic therapeutic antibodies therapeutic effect transgenic mice vaccination Vaccines variant variants Viral viral mutation virus virus-neutralizing Wuhan strain
[DOI] 10.1126/scitranslmed.abn7737 PMC 바로가기 [Article Type] Article

A humanized mouse model of chronic COVID-19

만성 COVID-19의 인간화 마우스 모델

Article

Published on 2022-06-012022-09-11
Journal: Nature biotechnology [Category] Fulltext, MERS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome adaptive adeno-associated virus antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease early infection feature fibrosis human ACE2 human immune response humanized immune response immune responses immunological immunopathology Infection Infectious disease Inflammatory inflammatory macrophage inflammatory macrophages Injury interferon interferon-stimulated gene lung Lung pathology Lungs lymphopenia Macrophage macrophages mechanism mice Patient respiratory Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease steroid Steroids sustained T cell T cell lymphopenia Viral Viral RNA weight loss
[DOI] 10.1038/s41587-021-01155-4 PMC 바로가기 [Article Type] Article

Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo

대규모 in vitro 스크리닝 및 in vivo 효과 평가를 통한 잠재적 anti-SARS-CoV-2 약물 발굴

Article

Published on 2022-06-012022-09-11
Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug approved drug candidate caused Cell culture cisatracurium clinical clinically Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment cytotoxicity D614G D614G variant develop drug Drug repurposing drug resistance Drug screening drugs effective Efficacy Gilteritinib hamster hamster model. hamsters HeLa cell HeLa cells human ACE2 IL-6 in vitro in vivo induce life cycle mRNA pandemic passage Postinfection promoted Prophylactic protective effect provided pulmonary viral reduced Remdesivir Salinomycin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle selected sertraline severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown suppressed the SARS-CoV-2 TNF-α transduced Treatment variety Vero E6 Vero E6 cell VERO E6 cells weight loss
[DOI] 10.1007/s11427-021-2031-7 PMC 바로가기 [Article Type] Article

Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19

Research

Published on 2022-05-112022-10-05
Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제,

Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19

SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과

Article

Published on 2022-05-042022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제,

[키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal Intestinal barrier intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus
[DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article

In Silico Prediction of New Mutations That Can Improve the Binding Abilities Between 2019-nCoV Coronavirus and Human ACE2

2019-nCoV 코로나바이러스와 인간 ACE2 간의 결합 능력을 향상시킬 수 있는 새로운 돌연변이의 실리코 예측

Article

Published on 2022-05-012022-09-11
Journal: IEEE/ACM transactions on computational biology and [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술,