human ACE2 receptor – Page 4 – Communicable Diseases Research

Phylogenetic and Ancestral Sequence Reconstruction of SARS-CoV-2 Reveals Latent Capacity to Bind Human ACE2 Receptor

SARS-CoV-2의 계통 발생 및 조상 서열 재구성으로 인간 ACE2 수용체 결합에 대한 잠재 능력 밝혀

Article

Published on 2021-12-012022-09-11
Journal: Journal of molecular evolution [Category] MERS, SARS, 진단, 치료기술, 치료제,

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

Article

Published on 2021-11-302022-10-04
Journal: Nature Communications [Category] MERS, SARS, 변종,

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Article

Published on 2021-11-252022-10-04
Journal: Nature Communications [Category] Fulltext, MERS, SARS, 변종, 조류인플루엔자,

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Article

Published on 2021-11-242022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii

Research Article

Published on 2021-11-182022-10-28
Journal: PLoS ONE [Category] COVID-19,

Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays

SARS-CoV-2에 대한 체액 면역 평가: 플라크 감소 중화 테스트 및 기존 및 대리 중화 분석의 다중 실험실 비교 검증

Research Article

Published on 2021-11-172022-09-12
Journal: Microbiology Spectrum [Category] MERS, SARS, 진단,

[키워드] addition antibody antibody tests approval assays characterized conducted Conventional COVID-19 COVID-19 vaccines death demonstrated ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluate Evaluating flow cytometry Health Organization human ACE2 human ACE2 receptor humoral Humoral immunity immune responses Immunity immunoserology include laboratory-confirmed Laboratory-confirmed COVID-19 lentiviral luciferase multitude natural immunity neutralization neutralization test neutralization tests Neutralizing Neutralizing antibodies Neutralizing antibody response offer outlined Patient plaque-reduction neutralization test platform Precision PRNT Protective protective immune response protective immunity pseudotype quantification reference standard SARS-CoV-2 SARS-CoV-2 PRNT SARS-CoV-2-neutralizing antibodies serological Serological assay specificity specimen surrogate Test Vaccine validation World Health Organization
[DOI] 10.1128/Spectrum.00886-21 PMC 바로가기 [Article Type] Research Article

Computational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor

인간 ACE2 수용체보다 SARS-COV-2에 대한 실질적으로 더 나은 예측 결합 친화력을 갖는 FAB CC12.3의 계산 재 설계

Article

Published on 2021-11-122022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 진단,

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

SARS-COV-2 불활성 백신에 의해 유도 된 항체 및 T 세포에 의한 관심의 변이체 인식

Clinical Trial

Published on 2021-11-092022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha antibodies antibody approved B.1.1.7 B.1.351 Beta Beta variant binding cellular response Cellular responses Chilean circulating variant clinical trial concern CoronaVac coronavirus D614G death rate Delta delta variant described detect dose elicited ELISPOT enrolled evaluate evaluated Gamma genetic difference genetic differences geometric mean Geometric means house human ACE2 receptor immune response immunization immunization schedule immunization schedules immunized immunogenic in-house ELISA inactivated induced Infection interferon interferon-γ-secreting T cell interferon-γ-secreting T cells Lineage microneutralization neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing capacity P.1 pandemic PBMC PBMCs Phase 3 phase 3 clinical trial promote Protective RBD Receptor binding domain Recognition reduced respiratory responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secreted secretion Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significant differences spike stimulate subject T cell immunity T cells tested the RBD the SARS-CoV-2 the vaccine titers Vaccine variant variants variants of concern virus Volunteer volunteers were used Wuhan Wuhan, China
[DOI] 10.3389/fimmu.2021.747830 PMC 바로가기 [Article Type] Clinical Trial

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

SARS-CoV-2 스파이크 단백질의 돌연변이 Y453F는 숙주 적응을 위해 밍크 ACE2 수용체와의 상호 작용을 향상시킵니다

Research Article

Published on 2021-11-082022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 receptor Active surveillance adaptive addition Amino acid amino acid change Analysis binding circulation Cluster convalescent sera convalescent serum COVID-19 patient COVID-19 patients demonstrated develop domain employee ENhance Evolution exhibited functional Genetic variant Host human ACE2 human ACE2 receptor humans identify infected with SARS-CoV-2 initial Interaction less MONITOR Mutation Netherland Netherlands ortholog outbreak Outbreaks position Prevent RBD domain receptor reservoirs risk SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 RBD sequence similarity Spike protein steric Structural analysis suggested susceptible susceptible hosts the RBD the spike protein therapeutic strategy Transmission transmitted Vaccine development Viral viral RBD virus widespread Y453F zoonotic
[DOI] 10.1371/journal.ppat.1010053 PMC 바로가기 [Article Type] Research Article

In silico binding profile characterization of SARS-CoV-2 spike protein and its mutants bound to human ACE2 receptor

SARS-CoV-2 스파이크 단백질 및 인간 ACE2 수용체에 결합된 돌연변이체의 인 실리코(in silico) 결합 프로필 특성화

Article

Published on 2021-11-052022-09-11
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected approach binding binding affinities binding affinity binding free energies binding free energy complexes coronavirus country COVID-19 decomposition domain drug resistance free energies free energy Free energy calculation and decomposition Free energy calculations G476S hACE2 hACE2 protein hotspot Hotspot residues human ACE2 human ACE2 receptor infect interfere investigated MD simulation molecular molecular dynamics Molecular mechanics mutant nine Novel coronavirus pandemic Poisson Protein–protein interaction protocol prototype provide RBD RBD mutations RBDs receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs spike spike glycoprotein Spike RBD/hACE2. Structure structures surface area V367F V483A Vaccine virus
[DOI] 10.1093/bib/bbab188 PMC 바로가기 [Article Type] Article