Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection
Research Article
[키워드] A549 cells
Accessory
accessory protein
Activation
antagonism
Antiviral
attenuate
binding
catalytic site
cell line
characterized
complex interaction
contribute
coronavirus
death
decrease
described
dsRNA
ENCODE
etiological agent
exhibited
expression
function
future work
Host
Host immune response
host responses
human airway
humans
IFN
IFNL1
immune antagonism
include
induce
Infection
Innate
innate immune pathway
Interaction
interferon
interferon antagonist
Interferon lambda
lack
Loss
MERS
MERS-CoV
MERS-CoV infection
MHV
Middle East
mouse hepatitis virus
mutant virus
Mutation
NS2
NS4b
nuclear
outbreak
Pathogenesis
Pathways
PKR
Protein
provide
related viruses
Replication
reported
required
respiratory syndrome coronavirus
robust
sequence
severe respiratory disease
similarity
suppress
tested
unique
Vaccine
viral accessory proteins
viral double-stranded RNA
viruses
Zoonotic coronavirus
[DOI] 10.1128/mBio.00319-19 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.00319-19 PMC 바로가기 [Article Type] Research Article