human proteins – Page 4 – Communicable Diseases Research

Gene variants of coagulation related proteins that interact with SARS-CoV-2

SARS-CoV-2와 상호작용하는 응고 관련 단백질의 유전자 변이체

Research Article

Published on 2021-03-172022-09-10
Journal: PLoS Computational Biology [Category] SARS, 변종, 유전자 메커니즘,

SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets

SARS-CoV-2 3D 데이터베이스: 코로나바이러스 프로테옴 이해 및 가능한 약물 표적 평가

Problem Solving Protocol

Published on 2021-03-082022-09-10
Journal: Briefings in Bioinformatics [Category] SARS, 치료제,

[키워드] 3D model 3D models 3D structure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding characterized Computational approaches coronavirus Coverage database docking download Drug discovery drug target evaluate experimental structure focus high mortality human proteins Impact Infectious disease information Interaction International knowledge mapped Model mutations oligomers protein-ligand proteome proteome analysis provide respiratory SARS CoV-2 SARS-CoV-2 SARS-CoV-2 3D database SARS-CoV-2 drug targets SARS-CoV-2 genome sequence SARS-CoV-2 protein SARS-CoV-2 proteome modelling sequence severe acute respiratory syndrome Coronavirus Spread structures target targets the SARS-CoV-2 genome
[DOI] 10.1093/bib/bbaa404 PMC 바로가기 [Article Type] Problem Solving Protocol

Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention

Comment

Published on 2021-01-012022-10-04
Journal: Cell stress & chaperones [Category] SARS, 신약개발,

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

DNA 복구-복제 인터페이스 및 SARS CoV-2를 표적으로 하는 핵산 효소에 대한 구조 기반 억제제에 대한 효율적인 화학적 스크리닝 방법

Article

Published on 2021-01-012022-09-11
Journal: Molecules [Category] Coronavirus, 유전자 메커니즘,

[키워드] Absorption ADME ADP-ribose affinity approach approved Cancer cancer cell Cancer cells Cassandra CASSIE Cell Chemical Chemical library Chemistry classical Compound defined distribution DNA DNA replication DNA replication and repair docking drug drug design Drug discovery effective effort enzyme excretion facilitate human protein human proteins increasingly inhibitor inhibitors iterative Mac1 macrodomain mechanism metabolism molecular nonstructural protein 3 Nsp3 nucleic acid optimization PARG Pathogenesis pathway predicted problem profiles protein 3 Proteins provide repair ribose RNA SARS CoV SARS CoV-2 SARS-CoV2 Screen screening method specific inhibitor specific inhibitors Structure structures target to define
[DOI] 10.1016/bs.mie.2021.09.003 PMC 바로가기 [Article Type] Article

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease

SARS-COV-2 주요 프로테아제의 숙주 세포 단백질 기질의 확인

Article

Published on 2020-12-152022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 3CL Protease 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithms Analysis causative agent cellular cleavage cleavage site cleavage site identification cleavage site prediction cleavage sites cleaved contribute coronavirus coronavirus disease Coronavirus disease-19 COVID-19 CTBP1 develop help highlight homologous Host host cell host protein cleavage Human human protein human proteins identification In silico method in vitro Interaction knowledge Like limitation main protease molecular mechanism molecular mechanisms NetCorona Pathogenesis pathogenesis of SARS-CoV-2 polyprotein predict predicted processed protease Protein protein sequence Replication respiratory SARS SARS-CoV SARS-CoV-2 sequence severe pneumonia SSHHPS substrate target tested Viral viruses was used
[DOI] 10.3390/ijms21249523 PMC 바로가기 [Article Type] Article

CovMulNet19, Integrating Proteins, Diseases, Drugs, and Symptoms: A Network Medicine Approach to COVID-19

Original Research: COVID-19 Research in Network and Systems Medicine

Published on 2020-11-172022-10-30
Journal: Network and Systems Medicine [Category] COVID-19,

[키워드] Analysis approach bootstrap Comorbidities Comorbidity Complex networks Compound condition conditions COVID-19 COVID-19 patients disease Disease network drug Extensive Factors human proteins Inclusion Interaction interactome intestinal material Medicine molecular molecular interaction multidimensional network network analysis Neurological disease pathology patients Proteins randomization Randomized reported representing risk factor SARS-CoV-2 proteins similarity Symptom Symptoms the disease treat
[DOI] 10.1089/nsm.2020.0011 PMC 바로가기 [Article Type] Original Research: COVID-19 Research in Network and Systems Medicine

In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm

In-silico 약물 용도 변경 연구는 SARS-CoV-2 감염 진행 및 사이토카인 폭풍으로 인한 호흡 곤란을 줄이기 위한 유망한 후보 요법으로 피르페니돈과 멜라토닌의 조합을 예측합니다

Research Article

Published on 2020-10-022022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS,

[키워드] Acute kidney injury acute respiratory syndrome alternative method approach approaches cardiac injury caused Combination contribute COVID-19 COVID-19 treatment Cytokine storm distress drug drug combination drug target drugs GUILDify v2.0 GUILDify v2.0 web server human protein human proteins in some infected patient infected patients Infection infection cycle Injury melatonin multiorgan failure non-severe symptomatic patient non-severe symptomatic patients pathology Patient Pirfenidone potential COVID-19 treatments predict predicted producing progression pulmonary complications reduce respiratory respiratory symptom respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection Sepsis Septic shock Severe acute respiratory syndrome stage II Standard of care starting System biology the disease therapeutic effect therapy Treatment treatments for COVID-19 virus virus infection web server
[DOI] 10.1371/journal.pone.0240149 PMC 바로가기 [Article Type] Research Article

Don’t sugar coat the COVID (only the vasculature)

COVID를 설탕 코팅하지 마십시오(혈관만)

Editorial

Published on 2020-10-012022-09-11
Journal: Biomedical journal [Category] SARS, 치료제,

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

Short Report

Published on 2020-05-262022-10-31
Journal: eLife [Category] COVID-19, MERS, SARS,

[키워드] ACE2 Activation acute respiratory distress syndrome adopted Affect airway Amino acid Analysis block cause Cell cell type cells cellular cleavage cleavage site cleave conditions coronavirus COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 patients Critical diagnose dysregulation ENaC enzyme epithelial explain expression global pandemic Health help highlight highlighting homeostasis Host host cell Human human cell human lung human proteins human respiratory cells identify identifying infect interfere lifecycle lung Lungs mechanism molecular mimicry mouse organ overlap pathophysiology patients peptide Prevent protease Protein Proteins proteolytic proteolytic activation receptor ACE2 remained respiratory tract respiratory tract cell resulting RNA-Seq S1/S2 cleavage site SARS-CoV-2 sequence sequenced severe respiratory symptoms sodium spike the SARS-CoV-2 the spike protein treat unique virus
[DOI] 10.7554/eLife.58603 PMC 바로가기 [Article Type] Short Report

Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity

Short communication

Published on 2020-04-092022-10-30
Journal: Journal of Translational Autoimmunity [Category] COVID-19,

[키워드] adaptive immune system Antigen Antigen presentation Autoantigens Autoimmunity Bacteria candidate class consequence contribute COVID-19 COVID-19 disease Critical element epitope excluded expected explain exposure failure genes encoding had no homologous homology human protein human proteins Immune Enhancement immune system immunogenic immunological priming Immunopathogenesis in viral indicate Infection injection involved Local lung tissue mapping MERS MERS spike protein MHC Mortality outcomes Pathogenesis pathogenic Pathogenic priming pathway peptide priming Protein provide responsible risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Signaling similarity Spike proteins Symptom target Trial vaccination Vaccine Vaccine development Viral protein virus
[DOI] 10.1016/j.jtauto.2020.100051 PMC 바로가기 [Article Type] Short communication