CoVM 2: Molecular Biological Data Integration of SARS-CoV-2 Proteins in a Macro-to-Micro MethodCoVM 2: 거시적 방법에서 SARS-CoV-2 단백질의 분자 생물학적 데이터 통합Article Published on 2022-08-022022-09-11 Journal: Biomolecules [Category] SARS, 변종, 치료기술, [키워드] accumulated addition Affect analyzed association B.1.617.2 binding binding affinity binding state Biological calculated causative agent changes in collected COVID-19 COVID-19 pandemic crystal structure crystal structures Data integration Delta docking examined glycoprotein human proteins human receptor human receptors information integration Interaction lack macro molecular Molecular biology Multiple Mutation omicron physical PPI network Protein protein interaction protein structure protein structure docking protein-protein interaction public health receptor protein Research S protein S proteins SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected sequence strain Structure structures variant variants Viral protein Viral proteins virus–host interactions [DOI] 10.3390/biom12081067 PMC 바로가기 [Article Type] Article
A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection Research Published on 2022-07-062022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] anti-SARS-CoV-2 antibody approach clinical observation clinical presentation contribute COVID-19 Critical cross-react cross-reactive antibody disease domain driving epitope evaluate function human protein human proteins Hypothesis identify indication linear epitopes novel SARS-CoV-2 virus Pathologies pathology Protein response SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 Wuhan strain structural homology Therapies understanding unmet need with COVID-19 [DOI] 10.1038/s41598-022-15225-3 [Article Type] Research
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human ProteinsSARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens [DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article
Autoimmune Effect of Antibodies against the SARS-CoV-2 NucleoproteinSARS-CoV-2 핵단백질에 대한 항체의 자가면역 효과Article Published on 2022-05-252022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Affect Analysis analyzed antibodies antibody Antibody Response Antibody titer autoantibodies autoantibody Autoimmune autoimmune reactions Autoimmunity caused complications conformational Consequences contribute coronavirus Coronavirus infection correlation correlations Course COVID-19 COVID-19 symptoms Cross reactivity debate deteriorate disease severity Effect ELISA epitope Epitopes HLA HLA allele HLA alleles human protein human proteins IgG antibodies IgG antibody induce life linear New nucleocapsid protein nucleoprotein patients with COVID-19 performed SARS-CoV-2 severity shown Spread strain susceptible Symptoms target the antibody response the disease the SARS-CoV-2 Vaccine Viral protein Viral proteins western blot [DOI] 10.3390/v14061141 PMC 바로가기 [Article Type] Article
Predicted coronavirus Nsp5 protease cleavage sites in the human proteomeResearch Published on 2022-04-042023-07-01 Journal: BMC Genomic Data [Category] COVID19(2023년), SARS, [키워드] 3CLpro coronavirus COVID-19 human proteins Human proteome MPro nsp5 protease SARS-CoV-2 [DOI] 10.1186/s12863-022-01044-y PMC 바로가기 [Article Type] Research
Widespread occurrence of covalent lysine-cysteine redox switches in proteins단백질에서 공유 라이신-시스테인 산화 환원 스위치의 광범위한 발생Article Published on 2022-04-012022-09-11 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding coronavirus cysteine cysteines database DNA domain effectors enzyme Gene Expression homeostasis human protein human proteins instances life lysine motif nitrogen NOS Occurrence oxygen Pathogens pathophysiological conditions physiological plant pathogens Protein protein structure Proteins Regulatory reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling substrates sulfur trivalent variants whole protein [DOI] 10.1038/s41589-021-00966-5 PMC 바로가기 [Article Type] Article
Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-CCOVID-19가 있는 성인 및 소아 환자와 MIS-C를 가진 어린이에서 이전에 자가면역과 연관되었던 단백질에 대한 자가항체Article Published on 2022-03-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, 진단, 치료제, [키워드] administration Against Analysis antibody Antigen antigens ATPase autoantibodies autoantibody autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity both groups children COVID-19 declined defined detect diabetes gastritis human protein human proteins IgA antibodies IgA antibody IgG Immunoglobulin in both group in vivo Inflammatory insulin-dependent diabetes Intravenous immunoglobulin IVIG Kawasaki disease KCNRG KLHL12 lung MIS-C MIS-C multisystem inflammatory syndrome in children monitoring Patient patients patients with COVID-19 Protein responsible Ro60 subset syndrome target therapy troponin undetectable while with COVID-19 [DOI] 10.3389/fimmu.2022.841126 PMC 바로가기 [Article Type] Article
Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function독특한 SARS-CoV-2 ORF10 변이체의 출현과 단백질 구조 및 기능에 미치는 영향Article Published on 2022-01-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 변종, [키워드] acute respiratory syndrome coronavirus And ubiquitin ligase complex caused Co-occurring mutations comprehension Consequences coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CUL2 disorder Effect ELOB ELOC emergence expected expressed Frame highlight host protein human protein human proteins interact intrinsic Intrinsic protein disorder lung tissue MAP7D1 Mutation Open reading frame ORF10 pathogenicity PPT1 predicted Protein public health RBX1 Research respiratory SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single mutation THTPA TIMM8B ubiquitin ligase unique variant variants virulence virus ZYG11B [DOI] 10.1016/j.ijbiomac.2021.11.151 PMC 바로가기 [Article Type] Article
Embeddings from protein language models predict conservation and variant effectsArticle Published on 2021-12-302022-11-15 Journal: Human Genetics [Category] COVID19(2023년), SARS, 변종, [키워드] Algorithm alignment Amino acid analyses applied approach data set database deep deep learning Effect embedding entire sequence expand experiment fraction human proteins investigated language Local Logistic regression magnitude Model Multiple sequence alignment Nvidia Pearson correlation predict predicted prediction Probability Protein protein sequences Proteins proteome regions residue RTX SARS-CoV-2 variant scanning score sequence Sequence conservation significantly Spearman statistically supplementary material variant while [DOI] 10.1007/s00439-021-02411-y PMC 바로가기
Thromboses and Hemostasis Disorders Associated with COVID-19: The Possible Causal Role of Cross-Reactivity and Immunological ImprintingOriginal Article Published on 2021-12-262022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] adverse event bleeding Causal Coagulopathies commonality COVID-19 cross-reaction cross-reactive cross-reactivity Diseases disorder Epitopes extreme Hemostasis human protein human proteins immune system immunization immunological immunological imprinting Immunological memory Imprinting individual mutated natural infection pathogen pentapeptide peptide response role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike gp sequence thromboembolic thromboembolic complications thromboses thromboses-related proteins vaccinal Vascular vascular diseases Venous thrombosis [DOI] 10.1055/s-0041-1731068 PMC 바로가기 [Article Type] Original Article