Use of Baricitinib in Patients With Moderate to Severe Coronavirus Disease 20192019년 중등도 내지 중증 코로나바이러스 질환 환자에서 바리시티닙 사용Article Published on 2021-04-082022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] Baricitinib clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 Hydroxychloroquine hyper-inflammation hyperinflammation increased mortality investigated moderate patient cohort patients Randomized retrospective Treatment treatment of COVID-19 [DOI] 10.1093/cid/ciaa879 PMC 바로가기 [Article Type] Article
Elevated frequencies of CD14 + HLA-DR lo/neg MDSCs in COVID-19 patientsCOVID-19 환자에서 CD14 + HLA-DR lo/neg MDSC의 빈도 증가Research Paper Published on 2021-03-152022-08-31 Journal: Aging (Albany NY) [Category] MERS, 바이오마커, [키워드] albumin analyzed association B cell CD14 Cell change Clinical characteristics correlated correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression COVID-19 severity determined by disease severity elevated evaluate flow cytometry Follow-up Frequency greater HLA-DR Hospital stay hyper-inflammation ICU patient immune responses immunoparalysis Immunosuppression immunosuppressive laboratory data lymphocyte Lymphocyte count lymphocyte counts MDSC Most patients NK cell nucleic acid Oropharyngeal Patient percentage percentages positively correlated Prognosis SARS-CoV-2 SARS-CoV-2 nucleic acid serum albumin severe patients T cell Viral Viral load [DOI] 10.18632/aging.202571 PMC 바로가기 [Article Type] Research Paper
Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A HypothesisCOVID-19 병리에 대한 대사 내성을 증가시키기 위한 염증의 MMP 조절 목표: 가설Essay Published on 2021-03-062022-09-01 Journal: Biomolecules [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 AMPK Combination Coronavirus-2 COVID-19 damage develop elicit elicited energy metabolism Evidence focus Host human host hyper-inflammation immunopathology increase individual Infection Inflammation Interaction lung matrix metalloproteinase matrix metalloproteinases mechanism metabolic metabolic tolerance metabolism mild symptoms MMP Mounting multiorgan failure organ organs pathogen Pathogens Pathologies pathology Perturbation Pneumonia regulated respiratory respiratory distress Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spectrum syndrome systemic inflammation target target organ target organs targeting Therapeutic approach therapeutic approaches therapeutic target therapeutic targets tissue damage Viral while [DOI] 10.3390/biom11030390 PMC 바로가기 [Article Type] Essay
The role of extracellular DNA in COVID-19: Clues from inflamm-agingCOVID-19에서 세포외 DNA의 역할: 염증 노화의 단서Review Published on 2021-03-012022-09-12 Journal: Ageing research reviews [Category] MERS, SARS, 진단, [키워드] affected Anti-inflammatory contrary COVID-19 develop disease Diseases DNA DNA sensing receptors explain Extracellular extracellular DNA high mortality rate hyper-inflammation increase in Inflamm-aging Inflammation inflammatory pathways Inflammatory response inhibiting Local male men Misplaced DNA mitochondrial modulation multi-organ failure Prognosis reduction SARS-CoV-2 subject subjects systemic hyper-inflammation systemic inflammation telomere thrombotic complication turn variety women [DOI] 10.1016/j.arr.2020.101234 PMC 바로가기 [Article Type] Review
Animal models of COVID-19 hyper-inflammationComment Published on 2021-03-012023-07-12 Journal: Respirology (Carlton, Vic.) [Category] SARS, [키워드] animal models COVID-19 hyper-inflammation [DOI] 10.1111/resp.13997 [Article Type] Comment
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytesArticle Published on 2021-03-012022-10-04 Journal: Cell Death Discovery [Category] 치료제, [키워드] 2019 coronavirus disease Activation acute respiratory syndrome caspase-1 cellular component cleavage coronavirus COVID-19 critically ill patients death engage gasdermin D human monocytes hyper-inflammation IL-1ß Inflammasome Inflammatory response intensive care leukopenia mechanism monocyte Monocytes Patient Peripheral blood pro-inflammatory cytokine pyroptosis recruited reduce viral replication respiratory tract SARS-CoV-2 severe COVID-19 therapy Trigger viral infection [DOI] 10.1038/s41420-021-00428-w PMC 바로가기 [Article Type] Article
Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic ReviewNF-κB의 하향 조절을 위한 희귀 약물의 재배치를 위한 COVID-19의 과도한 면역 반응 이해: 체계적인 검토Review Published on 2021-02-272022-09-10 Journal: Viruses [Category] MERS, 신약개발, [키워드] adult COVID-19 patients article Autopsies biopsies clinical trial clinical trials country COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines demonstrated downstream drug effector eligibility English excess excess immune response Final Histamine histamine-conjugated-normal human immunoglobulin human immunoglobulin hyper-inflammation IL-10 IL-6 immune response Immunoglobulin immunological inhibit interleukin Joanna lack mechanism molecule molecules morbidity morbidity and mortality neutralization NF-κB nuclear translocation Orphan pathway pro-inflammatory cytokine pro-inflammatory cytokines reposition repositioning response resulting review Risk of bias SARS-CoV-2 screened searched Side effects Signaling specificity Therapeutics TNF-α TNFα tumour necrosis factor Tumour Necrosis Factor α upstream were used [DOI] 10.3390/v13030378 PMC 바로가기 [Article Type] Review
Modalities and Mechanisms of Treatment for Coronavirus Disease 2019Pharmacology Published on 2021-02-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome anti-viral agent block caused clinical trial clinician coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients current drug essential element event Host host immune system Hydroxychloroquine hyper-inflammation identify immune system immunization incidence infection process inflammatory reaction inhibit mechanism mechanisms Middle East modality neutralizing antibody pathologic plasma recognizing Research respiratory SARS-CoV-2 scientist Severity rate Spread syndrome therapeutic agents Transcription Treatment virus virus infection virus replication [DOI] 10.3389/fphar.2020.583914 PMC 바로가기 [Article Type] Pharmacology
Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 PatientsCell and Developmental Biology Published on 2021-02-052022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα [DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology
Cytokine Storm as a Cellular Response to dsDNA Breaks: A New ProposalImmunology Published on 2021-02-012022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Activation affected Apoptosis Cell cell death cells cellular DNA chromatin clinical trial copper COVID-19 Cytokine storm DNA damage dsDNA dsDNA breaks endotoxin Free radicals Genome healthy high mortality host cell hyper-inflammation hypothesise Inflammation Inflammatory cytokine Invasion involved mechanism mice New Particle preclinical study reduce mortality released reported response resulting resveratrol reversed severe COVID-19 shown storm therapeutic vicious cycle [DOI] 10.3389/fimmu.2021.622738 PMC 바로가기 [Article Type] Immunology