Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transitionShort Communication Published on 2020-09-092022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] Abnormalities ACE-2 activated Acute inflammation acute respiratory syndrome addition affected Angiogenesis angiopoetin-2 angiotensin Angiotensin 1-7 Anti-inflammatory Apoptosis blood vessel Cancer cancer cell cancer progression cancers cause cell proliferation cells cellular cellular entry Comorbidities coronavirus disease COVID-19 COVID-19 patient Cytokine storm Diffuse alveolar damage disrupt downregulation Effect EMT epithelial Express follow-up study form growth healthcare Heat shock HSP-27 phosphorylation hypothesise immune system induce infections Inflammatory Intussusceptive angiogenesis kidney malignancies Metastasis organ damage outbreak pandemic pathway Pathways Patient Phosphorylation pro-inflammatory progression proliferative Protein RAAS raise receptor responsible risk severe disease survivor susceptibility susceptible the disease tumour upregulated while [DOI] 10.3332/ecancer.2020.1099 PMC 바로가기 [Article Type] Short Communication
The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyondArticle Published on 2020-08-292022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] addition average blood flow blood flow promotion blood flow velocity Complication Concentration Contact COVID-19 Doppler endothelial Evidence examined Haemoglobin hypothesise IMPROVE increase induce involved knowledge limitation mechanism natural-mineral-based nanomaterial nitric oxide no difference novel novel coronavirus disease Oxide prevention of COVID-19 respiratory diseases SARS-CoV-2 shown significant increases in temperature therapy Treatment Vascular vessel was increased [DOI] 10.3390/nano10091699 PMC 바로가기 [Article Type] Article
Loop mediated isothermal amplification (LAMP) assays as a rapid diagnostic for COVID-19Research article Published on 2020-08-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 진단, [키워드] assist cDCs center Chinese clinical samples Combination Community Control coronavirus coronavirus disease coronavirus RNA COVID-19 demonstrated detect diagnosis of COVID-19 diagnostic diagnostic tests disseminate early diagnosis effective Effectiveness equipment exhibit form Health hypothesise improvement initial isothermal amplification loop Loop mediated isothermal amplification (LAMP) methodology Molecular assay Novel coronavirus nucleic acid amplification Patient polymerase chain Polymerase chain reaction (PCR) predicted Prevent prevention professional progression protocol protocols reagent reduction robust RT-PCR SARS-CoV-2 RNA Sensitivity and specificity shown significantly Spread subsequent viability Viral RNA viral spread virus [DOI] 10.1016/j.mehy.2020.109786 [Article Type] Research article
Azithromycin added to hydroxychloroquine for patients admitted to intensive care due to coronavirus disease 2019 (COVID-19)—protocol of randomised controlled trial AZIQUINE-ICUStudy Protocol Published on 2020-07-082022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] added addition Administered Admission allergy Azithromycin benefit clinical cohort of patient Combination Controlled trial coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 infection criteria Deterioration disease dose double-blind drug early administration Efficacy febrile disease groups hospital Hydroxychloroquine hypothesise ICU ICU admission in vitro include Infection intensive care intubation limit limitation lung mechanical ventilation mechanically ventilated Mortality not differ novel Novel coronavirus outcome outcomes pathway Patient patients Placebo Pregnancy Prevent prevented progressive COVID-19 Prospective randomised randomised controlled trial RCT receive Respiratory failure SARS-CoV-2 secondary severe COVID-19 Standard of care survival susceptible Symptom Treatment Trial viral replication [DOI] 10.1186/s13063-020-04566-x PMC 바로가기 [Article Type] Study Protocol
A multi centre randomized open label trial of chloroquine for the treatment of adults with SARS-CoV-2 infection in VietnamStudy Protocol Published on 2020-06-122022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 24 hours Can cause caused Chloroquine city clinical trial control arm Controlled trial Coronaviruses COVID COVID-19 defined detect effective evaluate exclusion criteria field Ho Chi Minh hospital hospitalised hypothesise Infection intervention arm Loading dose malaria management morbidity and mortality multi nine Novel coronavirus open label outcomes Parallel Arm Patient patients with COVID-19 people with COVID-19 pilot study positive Prevent primary endpoint randomised randomised clinical trial randomization Randomized randomized trial recruit Respiratory disease resulting RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Standard of care Swab swabs therapeutic Tolerability treat Treatment Trial Vaccine Vietnam viral clearance Viral load viral replication [DOI] 10.12688/wellcomeopenres.15936.1 PMC 바로가기 [Article Type] Study Protocol
Detection and characterisation of coronaviruses in migratory and non-migratory Australian wild birdsArticle Published on 2018-04-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] characterisation Charadriiforme collected conserved Contact coronavirus detect detection detection rate evaluated hypothesise Lineage lineages nucleotide sequence PCR PCR amplicon PCR assays positive positive sample regions selected sequence sequenced The United States [DOI] 10.1038/s41598-018-24407-x PMC 바로가기 [Article Type] Article
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial항레트로바이러스 요법(REALITY)을 시작하는 아프리카의 심각한 면역 저하 HIV 감염 개인의 사망률에 대한 즉시 사용 가능한 보충 식품의 효과: 공개, 병렬 그룹, 무작위 대조 시험Article Published on 2018-04-102022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI adverse event adverse events age analysed anti-infection Antiretroviral therapy ART assigned block size BMI body-mass body-mass index both groups CD4 cell Cell changes in children clinic visit Clinic visits computer-generated database Department development died Dispensing Effect eight Eligible participants Evidence evidence of finding funding global health GRADE greater hazard ratio high risk HIV infection hospital hypothesise Immunocompromised in both group individual individuals infected individuals infections Intention intention to treat Interaction ISRCTN ISRCTN registry Kenya log-rank Medical Research Council medication micronutrients Mortality no evidence of nutritional status Older Open-label outcome parallel-group participant Participants peanut per day Policy present Primary outcome Prophylaxis raltegravir randomisation randomised controlled trial Randomly ready-to-use therapeutic food reducing Registered reported Safety secondary Secondary outcomes Serious Adverse Event Serious Adverse Events significantly stratified sub-Saharan Africa Symptom Trial Uganda vital status weight weight gain Wellcome Trust would increase Z score Zimbabwe [DOI] 10.1016/S2352-3018(18)30038-9 PMC 바로가기 [Article Type] Article