IL-12 – Page 4 – Communicable Diseases Research

Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm

Immunology

Published on 2021-04-282022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1)

유행성 인플루엔자 A(H1N1)와 COVID-19를 구별하는 임상 및 면역학적 요인

Clinical Trial

Published on 2021-04-212022-09-12
Journal: Frontiers in Immunology [Category] MERS, 신종인플루엔자, 임상, 진단,

[키워드] acute respiratory distress syndrome acute respiratory syndrome alveolar CCL11 CCL3 characterized clinical clinically coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 pandemic cytokine levels demonstrated diagnostic Diseases dry cough Factor Frequency G-CSF Gastrointestinal symptom Health Hemisphere histological histopathological IFN-γ IL-10 IL-12 IL-13 IL-1ra IL-1β IL-4 IL-5 IL-6 immune factor Immune profile immune response immunological characteristics induce Inflammatory response Influenza Influenza A(H1N1) pdm09 interstitial Lung pathology Lungs other respiratory virus pandemic pandemic influenza patients patients with COVID-19 Pneumonia respiratory symptoms SARS-CoV-2 severe disease manifestation Th1 Th2 tissue injury TNF-α TSLP unique VEGF
[DOI] 10.3389/fimmu.2021.593595 PMC 바로가기 [Article Type] Clinical Trial

Early Differences in Cytokine Production by Severity of Coronavirus Disease 2019

Article

Published on 2021-04-012023-06-16
Journal: The Journal of Infectious Diseases [Category] MERS, SARS,

[키워드] asymptomatic infection COVID-19 IL-12 IL-2 Innate immunity
[DOI] 10.1093/infdis/jiab005 PMC 바로가기

SARS-CoV-2 Infection and Inflammatory Response in a Twin Pregnancy

쌍둥이 임신의 SARS-CoV-2 감염 및 염증 반응

Case Reports

Published on 2021-03-172022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 치료기술,

[키워드] abortion Analysis antibody production changes in Complication Concentration COVID-19 cytokine Cytokine storm Cytokines defined described diagnosed during pregnancy Dysbiosis Effect Evidence expressed fetal fetus G-CSF genital tract microbiome gestation healthy Hospitalization host susceptibility IL-12 IL-8 IL-9 immune system Immunological response infected patients Infection infections Infectious disease Infectious diseases Inflammatory response intensive care intensive care unit lead marker Microbiome microbiome composition Mortality Neonatal pattern placental pregnancies Pregnancy pregnant women Premature premature birth Preterm birth preterm labor producing response risk SARS-CoV-2 SARS-COV-2 infection spontaneous abortion susceptibility tested the SARS-CoV-2 tissue tissue tropism Transmission twin twin pregnancy vertical transmission virus with infection
[DOI] 10.3390/ijerph18063075 PMC 바로가기 [Article Type] Case Reports

Interleukin-18 in Inflammatory Kidney Disease

Medicine

Published on 2021-03-012022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?

다낭성 난소 증후군에서 대식세포 유래 사이토카인과 비타민 D 연관성: COVID-19 감염 위험 증가?

Endocrinology

Published on 2021-02-252022-09-11
Journal: Frontiers in Endocrinology [Category] MERS, 바이오마커,

[키워드] accounted alveolar macrophage aptamer basal BMI body mass body mass index both groups CD163 CD200 CD80 change changes in Concentration contribute correlated COVID-19 COVID-19 disease COVID-19 infection COVID-19 risk factors cross-sectional cross-sectional study CXCL5 cytokine Cytokines deficiency determine determined by elevated enhanced Factors greater IFN-γ IL-12 immune response in both group independent infection risk Inflammation Macrophage macrophage activation marker mass spectroscopy MMP9 obese obesity Ovary Plasma level Plasma levels plasma protein Polycystic polycystic ovary polycystic ovary disease Protective pulmonary disease Result risk risk factor severe COVID-19 disease Severe COVID-19 Infection slow stratified syndrome variable Vitamin Vitamin D vitamin D deficiency was measured women
[DOI] 10.3389/fendo.2021.638621 PMC 바로가기 [Article Type] Endocrinology

Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells From Coronavirus Disease 2019 Patients

Cell and Developmental Biology

Published on 2021-02-052022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] activated acute respiratory syndrome co-culture Concentration conditions Contact coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine dental dental pulp stem cells deregulated DPSC DPSCs form GM-CSF granulocyte healthy subject Human hyper-inflammation IFNγ IL-10 IL-12 IL-13 IL-17A IL-18 IL-1β IL-2 IL-21 IL-22 IL-23 IL-27 IL-4 IL-5 IL-6 IL-9 immune response immunomodulation in vitro interleukin investigated Macrophage mechanism mesenchymal stem cell Mesenchymal stem cells modulate modulation mononuclear cell MSC MSCs Multi-organ damage not affected Patient PBMC PBMCs peripheral Peripheral blood Pneumonia Production promote Pulp Real-time PCR Result SARS-CoV-2 STEM stem cell subset supernatant tissue regeneration TNFα
[DOI] 10.3389/fcell.2020.609204 PMC 바로가기 [Article Type] Cell and Developmental Biology

Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19

Pharmacology

Published on 2021-01-272022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] absence adjuvant alleviate Antiviral antiviral agent approach ARDS can be used caused chemokine chemokines Combination compounds Consequences COVID-19 COVID-19 pandemic CXCL8 cytokine Cytokine storm disease drug effective G-CSF GM-CSF Health HGF IL-10 IL-12 IL-13 IL-17 IL-1β IL-2 IL-4 IL-6 IL-7 IL-9 immune response Immunomodulatory agents Immunopathogenesis Immunosuppressant individual Infection inhibit inhibitory effect involved IP10 JAK/STAT Luteolin MCP1 morbidity and mortality natural NF-κB pathway Patient piperine plant-derived immunosuppressants Prevent pro-inflammatory cytokine resveratrol SARS-COV-2 infection Sepsis serious complication storm subsequent synergistic target targeting the cytokine storm the SARS-CoV-2 TNFα treat treating COVID-19 Treatment Vaccine while
[DOI] 10.3389/fphar.2020.583777 PMC 바로가기 [Article Type] Pharmacology

Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection

항체와 사이토카인 생산의 상호작용으로 CXCL13이 치명적인 SARS-CoV-2 감염의 잠재적인 신규 바이오마커로 밝혀짐

Research Article

Published on 2021-01-202022-09-10
Journal: mSphere [Category] 바이오마커, 진단, 치료법,

[키워드] Activation age Alpha Analysis analyzed anti-SARS-CoV-2 antibody antibodies antibody antibody level antibody levels Antigen antigens B cell Biomarker Blood blood type chemokine chemokine CXCL13 chemotactic marker chemotactic markers Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 virus CXCL13 cytokine Cytokine analysis cytokine response Cytokines develop disease disease severity elevated Eotaxin exhibited explain gamma interferon Germinal center healthy individuals help identify IFN-γ IL-12 IL-18 IL-2 IL-4 IL-6 IL-8 immune immune response immune system Immunity immunological Immunological response Increases increases in Infection information interferon interleukin interleukin 6 involved IP-10 knowledge lethal magnitude majority marker maturation MIP-1α Necrosis novel nucleocapsid outcomes Patient patient mortality patients who survived populations Potential produced Production proinflammatory Protein provide RANTES RBD Receptor binding domain S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 immunity SARS-CoV-2 pandemic SARS-CoV-2 patient SARS-CoV-2 patients severe COVID-19 Sex significant level specificity specimens systemic immune response TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha Variation Viral Viral proteins
[DOI] 10.1128/mSphere.01324-20 PMC 바로가기 [Article Type] Research Article

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험

Controlled Clinical Trial

Published on 2021-01-012022-09-11
Journal: Cell transplantation [Category] 유전자 메커니즘, 임상,

[키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF
[DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial