IL-1ra – Page 4 – Communicable Diseases Research

A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients

Original Article

Published on 2020-10-102022-10-04
Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단,

[키워드] Abstract Activation Antigen approach characterized CMV COVID-19 COVID-19 patient diagnostic diagnostic test disease endothelial Enterotoxin evaluated expressed FGF fibroblast G-CSF GM-CSF granulocyte-colony stimulating factor growth factor IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-15 IL-17A IL-1ra IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 Image immune response individual inflammatory protein interferon IP-10 Macrophage MCP-1 median MIP-1β monocyte chemoattractant protein-1 Multiplex analysis Necrosis objective parameters Patient PDGF peptide platelet-derived growth factor Protein RANTES regulated Result SARS-CoV-2 SARS-CoV-2 peptide SEB secreted Serology response significantly increased Specific response T cell T-cell T-cell based tests Th1 Th2 TNF-α Vaccine Vascular VEGF Whole blood with COVID-19
[DOI] 10.1016/j.cmi.2020.09.051 PMC 바로가기 [Article Type] Original Article

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

종단적 COVID-19 프로파일링은 IL-1RA 및 IL-10을 질병 중증도와 연관시키고 RANTES를 경증 질병과 연관시킵니다

Research Article

Published on 2020-07-092022-09-25
Journal: JCI Insight [Category] SARS, 바이오마커, 진단,

[키워드] Adaptive immunity Beijing You’an Hospital Blood CCL5 chemokine China Clinical management Combination COVID-19 COVID-19 disease severity COVID-19 patients cytokine Cytokines disease disease severity early stage elevated enrolled expression Follow-up GM-CSF healthy volunteers hospitalized COVID-19 patient identifying IFN-γ IL-1 receptor antagonist IL-10 IL-1ra IL-6 immune immune correlate immunoassay Infection inhibitory Intervention laboratory-confirmed late stage longitudinal majority Mild mild cases Mild symptom multiplex no significant difference outcomes Patient patients Peripheral blood predict Prevent prognostic biomarker RANTES severe COVID-19 illness severe disease significantly symptom onset Temporal analysis the cytokine storm TNF-α Treatment strategies Vaccine virus infection with mild disease
[DOI] 10.1172/jci.insight.139834 PMC 바로가기 [Article Type] Research Article

Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide

Cell Biology

Published on 2020-07-072022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] “cytokine storm” addition Anti-inflammatory anti-inflammatory activity anti-inflammatory cytokine applicability biologic caused cell line clinical trial clinical utility coronavirus COVID-19 Cytokine storm Cytokines evaluate furosemide Health host inflammatory response hypercytokinemia identify IL-1ra IL-6 IL-8 immuno-inflammatory in silico in vitro Inhaled inhibitor of IL-6 initial Innate immunity involved lethal infection LPS mechanism of action molecular docking morbidity and mortality multiple cytokine novel coronavirus SARS-CoV-2 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines promote Safe small molecule stimulated subsequent suppresse therapeutic therapy THP-1 TNF-α Treatment viral infection virus was reduced
[DOI] 10.7717/peerj.9533 PMC 바로가기 [Article Type] Cell Biology

Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist

톨-상호작용 단백질의 유전적 변이는 나병 감수성과 인터루킨 1 수용체 길항제의 피부 발현과 관련이 있다.

journal-article

Published on 2016-04-012024-08-01
Journal: Nanoscale [Category] 한센병,

[키워드] genetics IL-1 IL-1 receptor IL-1ra immune evasion leprosy Mycobacterium leprae skin immunity TLR regulation TOLLIP
[DOI] 10.1093/infdis/jiv570 [Article Type] journal-article