LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed miceArticle Published on 2022-06-012022-10-05 Journal: Virologica Sinica [Category] 두창, 비임상, 수두, 진단, 홍역, [키워드] adjuvant adopted Affect approved AS01B carriers CD4+ T cell Cell-mediated immunity Cell-mediated immunity (CMI) CMI comparable component COVID-19 mRNA vaccine CpG CpG oligodeoxynucleotide (CpG ODN) Efficacy ELISA enzyme-linked immunosorbent FDA hepatitis B herpes zoster Humoral immunity IFN-γ IgG antibody IL-2 Immunity Latent Lipid nanoparticle Lipid nanoparticle (LNP) LNP mice MOST motif number preclinical study proportion secreting splenocyte subunit Subunit vaccine T helper Th1 Vaccine Varicella zoster virus (VZV) virus virus glycoprotein [DOI] 10.1016/j.virs.2022.06.002 [Article Type] Article
Post-COVID-19 Fatigue and SARS-CoV-2 Specific Humoral and T-Cell Responses in Male and Female Outpatients남성 및 여성 외래 환자의 코로나19 이후 피로 및 SARS-CoV-2 특정 체액 및 T-세포 반응Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute COVID-19 acute infection Analysis assessment both sexes Clinical characteristics conducted Course COVID-19 development disease ELISA ELISPOT enzyme-linked immunosorbent evaluate Ex vivo examined fatigue female Germany humoral IFN-γ IFNγ IgG antibody IL-2 individual Inflammation interferon-γ Level male median time men mild infection not differ Outpatient outpatients participant pathophysiological mechanism producing response SARS-CoV-2 SARS-CoV-2-specific T-cell response scale Serum level significantly significantly lower Specific suffered T-cell T-cell Response T-cells treated university were measured women [DOI] 10.3389/fimmu.2022.902140 PMC 바로가기 [Article Type] Article
SARS-CoV-2-mRNA Booster Vaccination Reverses Non-Responsiveness and Early Antibody Waning in Immunocompromised Patients – A Phase Four Study Comparing Immune Responses in Patients With Solid Cancers, Multiple Myeloma and Inflammatory Bowel DiseaseSARS-CoV-2-mRNA 부스터 백신 접종은 면역 저하 환자의 무반응 및 조기 항체 약화를 역전시킵니다 - 고형암, 다발성 골수종 및 염증성 장 질환 환자의 면역 반응을 비교하는 4상 연구Clinical Trial Published on 2022-05-122022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] analyzed anamnestic response anamnestic vaccine-specific response antibody Antibody testing Autoimmune disease B-cell BNT162b2 booster booster vaccination Cancer patients CD19 cellular cellular response Control control group controls correlated COVID-19 cytokine response declined Effectiveness EudraCT group help highest humoral humoral and cellular vaccine-specific responses IBD identify IFN-γ response IgG IgG level IL-2 immune responses immunodeficiency IMPROVE individual Inflammatory bowel disease inhibitor inhibitors intervals knowledge mRNA mRNA vaccination mRNA-1273 Multiple Multiple myeloma Myeloma neutralizing antibody non-infected Open-label Patient patients patients treated patients under immunosuppression/immunomodulation Patients with cancer persistence phase response SARS-CoV-2 SARS-CoV-2 mRNA vaccination SARS-CoV-2 vaccination second dose Solid solid tumor SOT TNF-α Trial undetectable vaccination Vaccine waning of immune responses. [DOI] 10.3389/fimmu.2022.889138 PMC 바로가기 [Article Type] Clinical Trial
Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients눈물의 증가된 전염증성 사이토카인은 증상이 있는 COVID-19 환자의 결막 SARS-CoV-2 양성과 일치합니다Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] Biomarker Biomarkers collected Concentration conjunctival conjunctival sac Conjunctival secretion Conjunctival secretions COVID-19 patient COVID-19 patients cytokine level Cytokines determined by GM-CSF greater IFN-γ IL-10 IL-12 IL-1B IL-2 IL-4 IL-5 IL-6 IL-8 Increased Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune system magnetic bead ocular ophthalmic pathology Patient PCR testing positive Proinflammatory cytokine RNA RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity SARS-CoV-2 viral load selected significantly Swab Symptom symptomatic Tear tear film tears TNF-α Viral RNA [DOI] 10.1038/s41598-022-11285-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort studyCOVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구Article Published on 2022-05-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China [DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article
A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article
SARS-CoV2 wild type and mutant specific humoral and T cell immunity is superior after vaccination than after natural infectionSARS-CoV2 야생형 및 돌연변이 특이 체액성 및 T 세포 면역은 자연 감염 후보다 백신 접종 후 우수Article Published on 2022-04-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding Alpha antibodies antibody Antibody titer Antibody titers B.1.617.2 Blood blood sample Blood samples CD4 CD4+ T cell cytokine production delta variant Finger prick flow cytometric flow cytometric intracellular cytokine staining humoral IFN-γ IL-2 immune response immune responses Immunity Infection intracellular cytokine staining investigated mutant natural infection neutralisation no significant difference overcome pandemic Patient peptide peptides positive RBD RBD binding Receptor binding domain reduced response responses SARS-CoV2 significant difference significantly Specific Spike protein Stimulation strain Strong subject subjects T cell T cell response T cell responses tested the vaccine TNF-α vaccinated individuals vaccination variant variants Virus neutralization was reduced were measured wild type [DOI] 10.1371/journal.pone.0266701 PMC 바로가기 [Article Type] Article
Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccineSARS-CoV-2 BNT162b2-mRNA 백신 접종 3개월 후 항체 감소에도 불구하고 스파이크 특이적 T 세포 면역 지속Article Published on 2022-04-232022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] anti-RBD Anti-RBD antibody antibody Antigen boost cell-mediated immune cell-mediated response cellular correlation Effective vaccines effort evaluated expand HCW highlight Hospitalization humoral IFN-γ IL-2 immune response Immunity neutralization neutralizing antibody peptides persistence persistent produced public health measure reduce reduction SARS-CoV-2 SARS-CoV-2 transmission second dose spike T cell T-cell Th1 cytokine TNF-α to define vaccination Vaccine was performed Whole blood worker [DOI] 10.1038/s41598-022-07741-z PMC 바로가기 [Article Type] Article
In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individualsSARS-CoV-2-특이적 T 세포에 대한 심층 분석은 백신 접종을 받은 개인의 다양한 분화 계층을 보여줍니다Article Published on 2022-04-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Adaptive immune response Adaptive immunity Analysis approach breadth Breakthrough infection breakthrough infections CD4+ T cell CD4+ T cells clinical trial clinical trials COVID-19 COVID-19 pandemic cytokine profile determinant effective Efficacy feature fraction Fractions identify IL-2 immune immunology indicate individual induce investigated Last Longevity magnitude majority mutant produced reactive recall Region responders reveal S-protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells T cell T cell response T cells TNF-α vaccinated individual vaccinated individuals vaccination Vaccine variants of concern [DOI] 10.1172/jci.insight.156559 PMC 바로가기 [Article Type] Article
Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatologyArticle Published on 2022-04-012023-07-08 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), [키워드] B-cell IFNγ IL-2 SARS-CoV-2 T cell [DOI] 10.1002/iid3.595 PMC 바로가기