Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets
Review
[키워드] ACE2, angiotensin converting enzyme 2
BPs, bisphosphonates
cholesterol
CMV, human cytomegalovirus
CoV, coronavirus
DENV, dengue virus
EBOV, Ebola virus
FDPS, farnesyl diphosphate synthase
HCV, hepatitis C virus
HDL, high-density lipoprotein
HIV, Human immunodeficiency virus
HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
IAV, influenza A virus
IFN, interferon
IL, interleukin
KSHV, Kaposi's sarcoma-associated herpesvirus
LDL, low-density lipoprotein
lipid homeostasis
LXR, liver X receptor
MβCD, methyl-β-cyclodextrin
MERS, middle-East respiratory syndrome
Mevalonate pathway inhibitors
Mpro, SARS-CoV-2 main protease
MVA, mevalonate
PI, phosphatidil-inositol
RSV, respiratory syncytial virus
SARS-CoV-2
SARS, Severe acute respiratory syndrome
SREBP, sterol regulatory element binding protein
statins
Treg, T regulatory cells
TMPRSS2, Transmembrane Protease Serine 2
viral infections
VZV, Varicella zoster virus
WNV, West Nile virus
ZIKV, Zika virus
[DOI] 10.1016/j.plipres.2021.101099 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.plipres.2021.101099 PMC 바로가기 [Article Type] Review