HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis만성 B형 간염에 대한 치료 백신인 HeberNasvac은 선천 면역의 국소 및 전신 표지자를 자극합니다: SARS-CoV-2 노출 후 예방에 잠재적 사용Article Published on 2021-07-012022-09-11 Journal: Euroasian J Hepatogastroenterol [Category] 비임상, [키워드] Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral properties antiviral property both sexes breath CHB chronic chronic hepatitis Chronic Hepatitis B clinical trial Cohort coronavirus coronavirus disease COVID-19 Dengue died Disease progression dose enrolled evidenced expression functional Hepatocellular carcinoma immune cells Immunity immunomodulating immunomodulatory immunomodulatory effect impairment increased expression Innate innate immune cell Innate immune cells Innate immunity intranasal lethal infection Local Lymphocytes malignancies malignancy marker material mice monocyte Monocytes mononuclear cell nasopharyngeal Older Open-label pandemic Patient patients PBMC Peripheral blood periphery Postexposure Postexposure Prophylaxis Potential presenting prophylactic therapy Prophylaxis randomized clinical trial reduction in respiratory infections Result Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown subjects surrogate markers Symptom symptoms of COVID-19 systemic the patient therapeutic therapy Toll-like receptor Toll-like receptors tonsils Treatment Vaccine [DOI] 10.5005/jp-journals-10018-1344 PMC 바로가기 [Article Type] Article
Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients시스템 면역학 분석, 중증 COVID-19 환자의 면역병인 발생에 대한 폐 및 폐외 조직의 기여도 밝혀Immunology Published on 2021-06-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] activated addition Analysis APOA4 applied ASS1 B-cell B-cells BCL3 caused CBM CCL11 CD34 characterized CHI3L1 chronic inflammation complex contribute COVID-19 COVID-19 pandemic COVID-19 patient COVID19 CXCL1 cytokine cytokine production Cytokine storm Cytokines Cytokines storm DCLRE1C death dendritic cells dramatic increase dysregulated dysregulation eosinophil exacerbated Extrapulmonary extrapulmonary tissue extrapulmonary tissues Health heart heart tissue HLX HSP90AB1 IL2RA IL6 immune response immune responses immunology immunomodulatory effect Immunopathogenesis Inflammation inhibitor investigation ISG20 kidney LILRA5 liver lung lung tissue lung; modulate Monocytes MUC16 MUC17 MUC3A MUC4 MUC5B mucin multi-organ dysfunction NF-κB NF-κB signaling NFASC overexpression PARP14 potential mechanism potential mechanisms PTPN1 pulmonary resulting S100A12 SARS-CoV-2 SARS-COV-2 infection System T-cell T-cells the cytokine storm tissue tissues triggered upregulated WIPF3 [DOI] 10.3389/fimmu.2021.595150 PMC 바로가기 [Article Type] Immunology
Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestineResearch Article Published on 2021-06-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] absence Activation administration affected Antiviral Apoptosis coronavirus diarrhea distribution Effect ergosterol peroxide evaluate expression IFN-I immunomodulatory immunomodulatory effect in vitro study in vivo incidence Infection inhibited intestinal Intestinal barrier IκBα mechanisms modulation NF-κB p65 Porcine deltacoronavirus Prevent pro-inflammatory cytokine PROTECT protein expression reduced Replication signaling pathway small intestine tissues treat Treatment upregulating Viral load were infected [DOI] 10.1186/s13567-021-00955-5 PMC 바로가기 [Article Type] Research Article
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19Covid-19에 대한 Nigella sativa와 Thymoquinone의 가능한 치료 효과Review Published on 2021-06-102022-08-31 Journal: Pharmaceutical Biology [Category] SARS, 치료제, [키워드] animal Anti-inflammatory Antiviral antiviral effects cause Clinical studies clinical study clinical trial clinical trials Context COVID-19 database Effect Effects Efficacy flowering plant Google Scholar IFN-γ IgG1 IgG2a IL-12 IL-2 IL-4 IL-6 immunomodulation immunomodulatory effect immunomodulatory effects immunomodulatory properties immunomodulatory property infected patient infected patients ISI literature review mediators medicinal plant molecular docking Nigella Sativa Novel coronavirus objective Preliminary data pro-inflammatory mediator pro-inflammatory mediators Pulmonary function test randomize reduced respiratory respiratory disorders Respiratory system Result searched Serum level serum levels Severe infection suggested therapeutic effect thymoquinone Treatment Web of Science with COVID-19 [DOI] 10.1080/13880209.2021.1931353 PMC 바로가기 [Article Type] Review
Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its SupplementationArticle Published on 2021-05-282022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Asymptomatic baseline benefit Biochemical parameters cholecalciferol clinical Concentration concentrations control group coronavirus COVID-19 Critical D-dimer deficiency determine dose Effect ergocalciferol ferritin Follow-up immunomodulatory effect in both groups in viral Latin America Level Outpatient outpatients Patient positive Prognosis raise SARS-CoV-2 Serum level Supplementation supplemented group Symptom symptomatic the disease Transferrin Vitamin D vitamin D insufficiency vitamin D level vitamin D serum were measured [DOI] 10.3390/jcm10112378 PMC 바로가기 [Article Type] Article
Prophylactic effects of probiotics on respiratory viruses including COVID-19: a reviewReview Published on 2021-05-242022-10-31 Journal: Food Science and Biotechnology [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral antiviral activity AstraZeneca caused coronavirus Coronavirus disease 2019 COVID-19 dry cough Effect effective Fatality rate Fever Gut gut microbiome Health Host Immunity immunomodulatory effect include Interaction mechanisms metabolites Moderna Mutation occur Pfizer Probiotics Prophylactic prophylactic effect reported required Respiratory droplets respiratory virus SARS-CoV-2 Symptom therapeutic potential transmitted Vaccine viral infection viral infections viruses [DOI] 10.1007/s10068-021-00913-z PMC 바로가기 [Article Type] Review
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse ModelImmunology Published on 2021-05-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] biochemically candidate cells characterized Comparative Cytotoxic T cells driving generate glycosylation site humoral immune response immunization immunogenicity immunomodulation immunomodulatory effect Interaction investigated mice Model mouse neutralizing antibody neutralizing epitope potent Potential Protein RBD Receptor binding domain response robust SARS-CoV2 specificity spike Spike protein subunit Support T cell Th1 the SARS-CoV-2 the spike protein thermal stability Type unmet need vaccination Vaccine vaccine candidate Vaccine development viral entry [DOI] 10.3389/fimmu.2021.641447 PMC 바로가기 [Article Type] Immunology
Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial CellsCommunication Published on 2021-05-212022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Dolosigranulum pigrum Activation addition Administered Calu-3 cell CCL5 cellular damage combating commensal bacteria coronavirus coronavirus 2 Coronavirus infection COVID-19 culture supernatant CXCL10 CXCL8 cytokine profile demonstrated evaluate IFN-β IL-6 Immunity immunological mechanism immunomodulatory effect IMPROVE innate immune response involved mice modify modulated modulation next generation probiotics reducing reduction in respiratory respiratory commensal bacteria respiratory epithelial cell respiratory epithelial cells RSV SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 stimulated strain TLR3 Toll-like receptor 3 triggered viral replication [DOI] 10.3390/pathogens10060634 PMC 바로가기 [Article Type] Communication
COVID-19 and IL-6: Why vitamin D (probably) helps but tocilizumab might notCOVID-19 및 IL-6: 비타민 D(아마도)가 도움이 되지만 토실리주맙이 도움이 되지 않는 이유Review Published on 2021-05-152022-09-12 Journal: European journal of pharmacology [Category] 진단, [키워드] Administered administration antagonists Anti-inflammatory anti-inflammatory action antibody block conducted COVID-19 COVID-19 patient Cytokine storm Deleterious demonstrated effective Effects help IL-6 IL-6 antagonist Immune cell immunomodulator immunomodulatory effect interleukin involved Lower modulate monoclonal outcomes positive presenting pro-inflammatory pro-inflammatory action receptor receptors reducing reported Safe the cytokine storm therapeutic agent therapeutic option therapeutic target Tocilizumab Trial Vitamin D while [DOI] 10.1016/j.ejphar.2021.174031 PMC 바로가기 [Article Type] Review
Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequencesEchinacea purpurea (L.) 단핵구의 Moench 처리는 강장제 인터페론 신호 전달, 선천 면역 유전자 발현 증가 및 내인성 레트로 바이러스 서열의 DNA 반복 과메틸화 침묵을 촉진합니다Research Article Published on 2021-05-122022-09-10 Journal: BMC Complementary Medicine and Therapies [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Activation Analysis Antiviral change changes in characterisation chemokine chemotaxis common cold conserved CoV CpG Defense DNA DNA methylation Duration of infection Echinacea element epigenome experiment expression filgotinib Gene Expression genomic Herbal HERV HERVs IFN IFN signaling immunomodulation immunomodulatory effect induce inhibitor innate immune Innate immunity interferon interferon signaling involved janus Janus kinase kinase LTR monocyte Monocytes nuclear DNA Pathways Pattern recognition Pattern recognition receptors pharmacological promise promote Protective reduce Regulation respiratory Respiratory tract infections Result retroviral SARS-CoV-2 sequence Severe acute respiratory syndrome Signaling strain supplementary material Symptom Systems biology THP1 monocytes Transcription Transcriptome Treatment Trigger triggers Viral viral infections virus viruses [DOI] 10.1186/s12906-021-03310-5 PMC 바로가기 [Article Type] Research Article