in vitro model – Page 4 – Communicable Diseases Research

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

Research Paper

Published on 2021-06-102022-10-28
Journal: Redox Biology [Category] COVID-19, MERS, SARS,

Spheroids and organoids as humanized 3D scaffold-free engineered tissues for SARS-CoV-2 viral infection and drug screening

SARS-CoV-2 바이러스 감염 및 약물 스크리닝을 위한 인간화 3D 스캐폴드가 없는 조작된 조직으로서의 스페로이드 및 오르가노이드

Review

Published on 2021-06-012022-09-11
Journal: Artificial organs [Category] SARS, 신약개발, 치료제,

[키워드] 2019-nCoV 3D in vitro models acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal models antiviral drug antiviral drugs Cell culture cellular and molecular contribute coronavirus COVID-19 Disadvantages Diseases Drug discovery Drug screening effective effort event Health Organization High-throughput highlighting humanized in vitro in vitro model in vivo Infection infection model Infectious diseases joint life cycle New coronavirus Organoid organoids pandemic Research SARS-CoV-2 SARS-CoV-2 viral infection scaffold-free tissue engineering severe acute respiratory syndrome Coronavirus shown Spheroid spheroids. tissue tissue engineering Treatment viral infection viral life cycle WHO World Health Organization
[DOI] 10.1111/aor.13880 PMC 바로가기 [Article Type] Review

Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study

Miscellaneous

Published on 2021-05-222022-10-31
Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, SARS,

Strategies for the Production of Soluble Interferon-Alpha Consensus and Potential Application in Arboviruses and SARS-CoV-2

Article

Published on 2021-05-212022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Application of 3D bioprinting in the prevention and the therapy for human diseases

Review Article

Published on 2021-05-142022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] 치료제,

[키워드] addition application automated Diseases Drug discovery effective human disease in vitro model Infectious disease Medicine offer pathogen platform provide Rapid Research therapy tissue engineering Translational research Vaccine Vaccines
[DOI] 10.1038/s41392-021-00566-8 PMC 바로가기 [Article Type] Review Article

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

Medicine

Published on 2021-05-072022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] in vitro lung models acute respiratory distress affected alveolar alveolar epithelium alveolar regeneration ARDS assumed cause caused causing classical clinically collagen coronavirus coronavirus disease COVID-19 current DAD Diffuse alveolar damage disease ECM Effect Evidence Extracellular matrix fatal disease fibroblast in vitro in vitro model in vivo induce interstitial interstitial pulmonary fibrosis IPF knowledge lung Lung diseases Lung fibrosis lung organoids lung-on-chip mechanical stress molecular mechanism multicellular organoids Oxygenation pandemic Pathogenesis pathophysiological patients precision-cut lung slices proliferation Proteins pulmonary pulmonary fibrosis pulmonary impairment Pulmonary infection reduced respiratory SARS-CoV-2 SARS-COV-2 infection Symptoms syndrome tissue tissue regeneration treatment strategy Vaccine viral infections wound healing
[DOI] 10.3389/fmed.2021.644678 PMC 바로가기 [Article Type] Medicine

Mechanisms of radiation-induced endothelium damage: Emerging models and technologies

Review article

Published on 2021-05-012022-10-05
Journal: Radiotherapy and oncology : journal of the Europea [Category] 비임상,

[키워드] Activation acute radiation syndrome Adherens junctions AJAdherens junctions alteration apoptotic pathways ARSAcute radiation syndrome Ataxia telangiectasia-mutated ATMAtaxia telangiectasia-mutated biomimetic microfluidic assay bMFAbiomimetic microfluidic assay cardiovascular disease cell interactions cellular and molecular Central nervous system CNSCentral Nervous System Critical CVDCardiovascular disease Damage-associated molecular patterns DAMPDamage-associated molecular patterns develop Developing dysfunction ECEndothelial cell endothelial Endothelial cell Endothelium exposure G-CSFgranulocyte-colony stimulating factor Gastrointestinal Geranylgeranylacetone GGAGeranylgeranylacetone GIGastrointestinal GM-CSFGranulocyte/Macrophage Colony Stimulating Factor granulocyte-colony stimulating factor Granulocyte/Macrophage Colony Stimulating Factor Human umbilical vein endothelial cells HUVECHuman umbilical vein endothelial cells ICAM-1Intercellular adhesion molecule 1 IL-1interleukin-1 in vitro model in vivo Inflammatory response Injury Intercellular adhesion molecule 1 interleukin-1 ionizing radiation IRionizing radiation JAK1Janus kinase 1 JAM-CJunctional adhesion molecule-C Janus kinase 1 Junctional adhesion molecule-C knowledge LETLinear energy transfer leukocyte Linear energy transfer M-CSFmacrophage colony-stimulating factor macrophage colony-stimulating factor major histocompatibility complex management Manganese-dependent superoxide dismutase mechanism Medical countermeasures MHCMajor Histocompatibility Complex Microphysiological systems MnSODManganese-dependent superoxide dismutase morbidity and mortality MPSMicrophysiological systems NETsNeutrophil Extracellular Traps Neutrophil extracellular traps nuclear organ damage organs oxygen radical PAFPlatelet activating factor PAI-1plasminogen activator inhibitor type 1 pathology PDGFplatelet-derived growth factor PKCδProtein Kinase C-delta plasminogen activator inhibitor type 1 platelet activating factor platelet-derived growth factor Prevent protease PROTECT Protein Kinase C-delta Radiation radiological Radiotherapy reactive oxygen species resulting ROSreactive oxygen species SRSStereotactic radiosurgery stereotactic radiosurgery TBItotal body irradiation TEERTransendothelial electrical resistance TGFβTransforming Growth Factor-Beta therapeutic thought thrombomodulin tight junctions tissue tissue damage tissue injury TJTight junctions TMthrombomodulin TNF-αtumor necrosis factor-α total body irradiation Transendothelial electrical resistance Transforming Growth Factor-Beta Treatment tumor necrosis factor-α TYK2Tyrosine Kinase 2 Tyrosine Kinase 2 Vascular damage WBCWhite blood cells Weapons of mass destruction White blood cells WMDWeapons of mass destruction
[DOI] 10.1016/j.radonc.2021.02.007 [Article Type] Review article

ColdZyme Maintains Integrity in SARS-CoV-2-Infected Airway Epithelia

Research Article

Published on 2021-04-272022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

An in vitro model for assessment of SARS-CoV-2 infectivity by defining the correlation between virus isolation and quantitative PCR value: isolation success of SARS-CoV-2 from oropharyngeal swabs correlates negatively with Cq value

바이러스 분리와 정량적 PCR 값 간의 상관 관계를 정의하여 SARS-CoV-2 감염성을 평가하기 위한 시험관 내 모델: 구강 인두 면봉에서 SARS-CoV-2의 분리 성공은 Cq 값과 음의 상관 관계가 있습니다.

Research

Published on 2021-04-072022-09-01
Journal: Virology Journal [Category] MERS, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Applying calculated caused Cell Cell culture Chain Reaction coronavirus correlation COVID-19 patient Cq value decrease Diagnosis E-gene Epidemiological study experiment high risk highest in vitro in vitro model indication induce Infection infectious infective Infectivity inoculated Isolation Laboratory testing less long-lasting negative correlation novel Oropharyngeal oropharyngeal swab pandemic Pathogens Patient PCR polymerase chain polymerase chain reaction positive Probability Public public health qPCR Quantitation of viral infectivity Quantitative quantitative PCR quantitative polymerase chain reaction question raise respiratory Result retrospective risk factor risk of transmission RNA SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus significantly symptomatic Transmissibility Transmission Transmission pattern in vitro Viral Viral load viral pathogens virus virus isolation Virus titration
[DOI] 10.1186/s12985-021-01542-y PMC 바로가기 [Article Type] Research

Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium

Article

Published on 2021-03-232022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,