Aging and monocyte immunometabolism in COVID-19Editorial Published on 2021-04-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] aging COVID-19 immunometabolism immunosenescence inflammaging monocyte Monocytes [DOI] 10.18632/aging.202918 PMC 바로가기 [Article Type] Editorial
The aging lung: Physiology, disease, and immunityReview Published on 2021-04-022023-06-15 Journal: Cell [Category] Fulltext, MERS, [키워드] aging COPD COVID-19 healthspan Immunity inflammaging lung lung cancer metabolism oxidative stress Proteostasis pulmonary fibrosis senescence stress response [DOI] 10.1016/j.cell.2021.03.005 PMC 바로가기 [Article Type] Review
Effects of Different Dialysis Strategies on Inflammatory Cytokine Profile in Maintenance Hemodialysis Patients with COVID-19: A Randomized TrialArticle Published on 2021-03-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] affected approaches both groups circulating clinical outcomes collected Coronavirus disease-19 correlation COVID-19 COVID-19 patient cut-off cytokine level Cytokines Diagnosis dialysis Effect expanded hemodialysis ferritin Hemodialysis IFN-γ IL-10 IL-6 IL-8 inflammaging Inflammation Inflammatory marker Inflammatory response interleukin-6 lactate dehydrogenase lymphopenia maintenance medium membrane Modification modulation non-infected Pathogenesis Patient patients patients with COVID-19 performed profile Prospective Study protein-leaking dialyzer Randomized reduction in standard treatment Strategy sustained therapeutic target TLR4 Treatment two groups uncontrolled [DOI] 10.3390/jcm10071383 PMC 바로가기 [Article Type] Article
Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patientsCOVID-19 환자의 SARS-CoV-2 특이 항체의 혈청 수준에 대한 비만의 영향Research Article Published on 2021-03-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 바이오마커, 진단, [키워드] (C-reactive protein) (nonesterified fatty acids) acute respiratory syndrome amyloid A antibody Blood BMI Body body mass body mass index C-reactive protein chronic systemic inflammation condition Corona coronavirus coronavirus disease COVID-19 COVID-19 obese patient COVID-19 obese patients COVID-19 patient COVID-19 patients CRP evaluated exacerbated expected ferritin help Humoral immunity Hypothesis identify IgG antibodies immune dysfunction Immunity IMPROVE index individual inflammaging Inflammatory inflammatory conditions inflammatory markers Inflammatory response influence marker mass NEFA nonesterified fatty acids obese obese patients obesity Predictive Predictive value pro-inflammatory Protein pulmonary inflammation reduced respiratory Result risk SAA SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG secretion serum amyloid serum amyloid A protein Serum level serum levels Severe Acute Respiratory Syndrome Corona Virus Severe acute respiratory syndrome corona virus-2 shown specific IgG antibodies systemic inflammation [DOI] 10.1371/journal.pone.0245424 PMC 바로가기 [Article Type] Research Article
Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyondReview Published on 2021-02-092023-06-15 Journal: European Journal of Clinical Investigation [Category] MERS, SARS, [키워드] COVID‐19 inflammaging lifestyle Physical inactivity SARS‐CoV‐2 vaccination [DOI] 10.1111/eci.13485 PMC 바로가기 [Article Type] Review
Decreased serum levels of the inflammaging marker miR-146a are associated with clinical non-response to tocilizumab in COVID-19 patients염증 마커 miR-146a의 감소된 혈청 수준은 COVID-19 환자에서 토실리주맙에 대한 임상적 무반응과 관련이 있습니다Clinical Trial Published on 2021-01-012022-09-11 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] accounted adverse outcome affected age anti-IL-6 receptor biologic Biomarker Clinical course clinical response clinical trial COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 severity current death Decreased develop Digital disease droplet enrolled examined Health Healthcare systems healthy control inflammaging interleukin-6 interstitial pneumonia intravenous intravenous infusion lowest marker microRNA MicroRNAs miR-126 miR-146 miR-146a-5p miR-21 molecular non-responders Patient PCR quantified regulate respond responders RT-PCR Serum level serum levels serum sample serum samples subjects syndrome TCZ Tocilizumab Treatment [DOI] 10.1016/j.mad.2020.111413 PMC 바로가기 [Article Type] Clinical Trial
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19코로나19 염증, 면역노화, 자가면역의 초석에 있는 면역대사Review Published on 2020-12-312022-09-01 Journal: Aging (Albany NY) [Category] MERS, SARS, 바이오마커, 진단, [키워드] approach Autoimmune Autoimmunity common factor Comorbidities Comorbidity COVID-19 COVID-19 treatment dimethyl fumarate dysregulation fumarate immunometabolism immunosenescence inflammaging leads manifestation metformin occur opens Patient Prevent Rapamycin rapamycin-metformin-dimethyl fumarate risk severe COVID-19 severe disease SLE T-cell T-cell dysfunction T-cells targeting therapeutic strategy Treatment [DOI] 10.18632/aging.202422 PMC 바로가기 [Article Type] Review
Overcoming immune dysfunction in the elderly: trained immunity as a novel approachInvited Review Published on 2020-12-072024-09-04 Journal: International Immunology [Category] 대상포진, [키워드] aging immunosenescence inflammaging innate immune memory vaccination [DOI] 10.1093/intimm/dxaa052 PMC 바로가기 [Article Type] Invited Review
Age-related mitochondrial dysfunction as a key factor in COVID-19 diseaseReview Published on 2020-11-072023-06-16 Journal: Experimental gerontology [Category] MERS, SARS, [키워드] COVID-19 Cytokine storm inflammaging Inflammation Mitochondria Mitochondrial health Mitochondrial nutrients Mitochondrial turnover SARS-CoV-2 [DOI] 10.1016/j.exger.2020.111147 PMC 바로가기 [Article Type] Review
Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly populationReview Published on 2020-11-062022-10-29 Journal: Seminars in immunopathology [Category] COVID-19, MERS, SARS, [키워드] age boost candidate clinical study clinical testing Comorbidities complex COVID-19 cytokine effective Effectiveness effort exacerbate Factor fraction help identify immune responses immune responsiveness immunopathological immunosenescence inflammaging lack marker mechanism Older older population overlap pharmacological treatments phenotype Prognosis recent response risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 vaccine Systems biology tested vaccination vaccination efficacy Vaccination strategy Vaccine Vaccine development vaccine response virulence [DOI] 10.1007/s00281-020-00821-0 PMC 바로가기 [Article Type] Review