inflammasome activation – Page 4 – Communicable Diseases Research

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

Review

Published on 2021-01-162022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma

Research

Published on 2021-01-072022-10-28
Journal: Respiratory Research [Category] COVID-19,

[키워드] ACE2 angiotensin Asthma biopsies biopsy Blood body mass index clinical parameter Clusters Cohort Corticosteroid COVID-19 disease enzyme European examined expressed expression expression level functions furin FURIN gene Gender Gene Expression greater host cells inflammasome activation Inflammation inflammatory cells Invasion Level lung male Microarray molecular molecular phenotype morbidity and mortality mRNA expression multivariate analyses neutrophil neutrophilic Neutrophils outcome oxidative phosphorylation Phenotypes protease Proteases Result risk SARS-COV-2 infection serine 2 Severe asthma severity significantly significantly higher significantly increased sputum TMPRSS2 TMPRSS2 level transmembrane Type
[DOI] 10.1186/s12931-020-01605-8 PMC 바로가기 [Article Type] Research

The Inflammasome in Times of COVID-19

Immunology

Published on 2020-10-082022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Activation Activation of caspase-1 acute respiratory distress acute respiratory syndrome affected ARDS Brain caspase-1 contribute coronavirus CoV infection COVID-19 COVID-19 patients CoVs digestive disease downstream Effect genus Betacoronavirus Hyperactivation IL-1beta IL-1β IL-6 Infection Inflammasome inflammasome activation Inflammation Inflammatory cytokine Inflammatory response intestine involved kidneys Lungs mechanism MERS Middle East multiprotein complex nervous system potential mechanism renal respiratory infection responsible shown syndrome time tissue variety Ventilator-induced lung injury
[DOI] 10.3389/fimmu.2020.583373 PMC 바로가기 [Article Type] Immunology

Hyperexpression of type III secretion system of Salmonella Typhi linked to a higher cytotoxic effect to monocyte-derived macrophages by activating inflammasome

article

Published on 2020-09-302024-09-01
Journal: Microbial Pathogenesis [Category] 살모넬라증,

[키워드] inflammasome activation Salmonella pathogenicity island-1 Salmonella Typhi type III secretion system
[Article Type] article

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review

Review

Published on 2020-09-092022-10-04
Journal: Virus research [Category] SARS, 유전자 메커니즘,

[키워드] accompanied addition C-lectin pathways candidate gene Case report caused CCR1 CCR9 coronavirus coronavirus endoribonuclease COVID-19 COVID-19 case COVID-19 GWAS COVID-19 pathogenesis Cytokine storm DC-SIGN DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin DC-SIGNDendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin deficiency Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin disease double-strand RNA dsRNA, double-strand RNA dsRNAdouble-strand RNA dysregulated endoU, coronavirus endoribonuclease endoUcoronavirus endoribonuclease Evidence explain expression genetic study Genetic variant genome wide association studies GWAS GWAS, genome wide association studies GWASgenome wide association studies Herpes Simplex Virus 1 herpses simplex encephalitis Host host genetics Host immune defenses HSE, herpses simplex encephalitis HSEherpses simplex encephalitis HSV-1, Herpes Simplex Virus 1 HSV-1Herpes Simplex Virus 1 Human hypothese IL-18 IL-18 binding protein IL-18BP, IL-18 binding protein IL-18BPIL-18 binding protein immune immune response gene immune system implicated inborn errors of immunity Inclusion Inflammasome inflammasome activation Interaction interferon Interleukins International Union of Immunological Societies IUIS, International Union of Immunological Societies IUISInternational Union of Immunological Societies lactate dehydrogenase latency LDH, lactate dehydrogenase LDHlactate dehydrogenase lectin manifestation medical subject heading MeSH, medical subject heading MeSHmedical subject heading Meta-analysis minor allele frequency NLRP1 objective OMIM, Online Mendelian Inheritance in Man (OMIM) OMIMOnline Mendelian Inheritance in Man (OMIM) Online Mendelian Inheritance in Man (OMIM) Pathogenesis pathway Pathways PBMCs, peripheral blood mononuclear cells PBMCsperipheral blood mononuclear cells Peripheral blood mononuclear cells Protein reported Result SARS Coronavirus SARS coronavirus 2 SARS-coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2, SARS Coronavirus 2 SARS-CoV-2SARS Coronavirus 2 SARS-CoV, SARS Coronavirus SARS-CoVSARS Coronavirus severe COVID-19 Study design susceptibility systematic review therapeutic targets TLR pathway TLR pathways treatment for COVID-19 variant viral disease viral infection Viral susceptibility
[DOI] 10.1016/j.virusres.2020.198163 PMC 바로가기 [Article Type] Review

Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation

Article

Published on 2020-07-312022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] ACE2 ASC caused CCL20 CCL5 CCR1 cellular receptor chemokine COVID-19 COVID-19 infection COVID-19 pandemic CXCL1 CXCL2 CXCL8 Cytokine dysregulation Cytokine storm Cytokines dataset demonstrated dysregulation Electronic cigarettes Epidemics exacerbate Genes hallmark IL-1B immune response implicated independent Infection Inflammasome inflammasome activation inflammasomes Inflammation Nicotine NOD2 outcome overlap pathway pro-inflammatory cytokine Release risk RNA expression SARS-CoV-2 severe cases smoker Smokers smoking susceptibility the SARS-CoV-2 virus Tobacco upregulate upregulated upregulation vaping
[DOI] 10.3390/ijms21155513 PMC 바로가기 [Article Type] Article

Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients

Opinion

Published on 2020-07-232022-10-28
Journal: Aging and Disease [Category] COVID-19,

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

세포외 HMGB1: 코로나19를 포함한 중증 폐염증 치료 표적?

Review

Published on 2020-05-072022-08-13
Journal: Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease activated activated innate immunity cells acute respiratory distress acute respiratory distress syndrome Apoptosis ARDS Blood cause cells from males cellular cytosol complexes concentrations coronavirus disease COVID-19 COVID-19-associated inflammation cytokine cytosolic DAMP DAMPs danger molecule Danger molecules detrimental disease Disulfide Disulfide-HMGB1 dying cell dying cells endocytosed endocytosis endogenous damage-associated molecular pattern endolysosomal system endothelial cells expressed expression Extracellular extracellular DNA Extracellular HMGB1 extracellular SARS-CoV-2 RNA female form HMGB1 identify in vivo individuals induce inflammasome activation Inflammation Influenza initiate innate immunity cells lung Lungs lysosome Lysosomes lytic cell death molecular molecule HMGB1 Necrosis Novel coronavirus novel coronavirus disease observation other molecules PAMP PAMPs pathogen pathogen-associated molecular Pathogenesis pathogenic molecule Pathways physiological plasma Pneumonia pro-inflammatory cytokine pro-inflammatory cytokine release proinflammatory receptor pulmonary endothelial cell pulmonary endothelial cells pulmonary inflammation RAGE reduction released respiratory distress Respiratory distress syndrome RNA SARS-CoV-2 secreted syndrome Therapeutic compounds therapeutic target therapy TLR4 TLR4 receptor TLR4 receptors transfer transported Trigger triggers venous venous blood
[DOI] 10.1186/s10020-020-00172-4 PMC 바로가기 [Article Type] Review

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

article

Published on 2019-06-302024-09-01
Journal: Autophagy [Category] 살모넬라증,

[키워드] ATP6V0D2 Autophagosome-lysosome fusion IL1B inflammasome activation
[Article Type] article

Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation

article

Published on 2018-01-312024-09-01
Journal: EMBO Reports [Category] 세균성이질,

[키워드] cIAPs GLMN inflammasome activation Shigella
[Article Type] article