intranasal – Page 4 – Communicable Diseases Research

High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

Omicron SARS-CoV-2 및 사전 출현 코로나바이러스에 대한 친화성 성숙 ACE2 유인물의 높은 활성

Article

Published on 2022-08-252022-09-11
Journal: PLoS ONE [Category] SARS, 변종,

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage

비강 또는 고환 경로에 의한 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염은 고환 손상을 유발합니다

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 신종인플루엔자, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis asymmetric Awareness caused Cell change changes convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 damage death decrease degeneration delta variant demonstrated Depletion Disruption epididymal epithelial cells expressing hamster hamsters hemorrhage histopathological hypogonadism immune complex immunological change induce Infection Inflammation Influenza Influenza virus injection interstitial cell interstitial cells intranasal investigated Leydig cell Leydig cells lung tissues men Necrosis nucleocapsid omicron Pathogenesis Pneumonia prevented protein expression reduction in respiratory respiratory tract infection route SARS-CoV-2 SARS-CoV-2 nucleocapsid seminiferous Sertoli serum severe acute respiratory syndrome Coronavirus Sex sex hormone Sperm sperm count spermatogenesis spermatogenic cell spermatozoa subfertility subsequent testes testicle testicle. Testicular Testosterone vaccination variant Viral load viral loads Virological virus inoculum weight while wild-type SARS-CoV-2 worsening
[DOI] 10.1093/cid/ciac142 PMC 바로가기 [Article Type] Article

A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike

6-프롤린 안정화된 융합전 스파이크를 발현하는 매우 효과적인 약독화성 볼거리 바이러스 기반 SARS-CoV-2 백신 후보

Article

Published on 2022-08-162022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] antibody backbone candidate children COVID-19 vaccine Delta delta variant Delta variants effective expressed expressing expression Genome hamster human vaccine IFNAR1 immune responses Immunity immunization immunogenic Immunoglobulin immunoglobulin A include Infant Infants intranasal junction mice MMR MMR vaccine mucosal mump mumps virus neutralized Neutralizing antibodies neutralizing antibody prefusion proline prolines raised rapid increase Safe SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein T cell tetravalent Vaccine vaccine strain variants virus
[DOI] 10.1073/pnas.2201616119 PMC 바로가기 [Article Type] Article

Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2

Article

Published on 2022-08-152022-11-16
Journal: Frontiers in Immunology [Category] SARS, 변종,

[키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC
[DOI] 10.3389/fimmu.2022.948431 PMC 바로가기

Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants

Article

Published on 2022-08-082022-10-06
Journal: Med (New York, N.Y.) [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acting acute respiratory syndrome Administered administration antibody approved B.1.1.529 breadth cell line cGMP characterized coronavirus COVID-19 CRIPT DARPA defined diagnosed domains Emergency use FDA H2L2 mice Harbor human clinical trials human IgG1 intranasal intranasally intravenous intravenously K18-hACE2 transgenic mice LALA limit lineages Live virus lung titer NAb neutralization assays Neutralizing Neutralizing activity neutralizing antibody omicron Omicron BA.1 Omicron BA.1.1 Omicron BA.2 Pre-clinical research provided pseudotype quantitation reduced required retained SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike subset tested therapeutic Therapies treat vaccination variant variants of concern virus weight loss
[DOI] 10.1016/j.medj.2022.08.002 PMC 바로가기 [Article Type] Article

Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

SARS-CoV-2 스파이크 단백질을 발현하는 약독화된 재조합 뉴캐슬병 바이러스의 비강내 투여는 높은 중화 항체 수준을 유도하고 햄스터의 실험적 공격 감염으로부터 보호합니다

Article

Published on 2022-08-052022-09-12
Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단,

An intranasal ASO therapeutic targeting SARS-CoV-2

SARS-CoV-2를 표적으로 하는 비강내 ASO 치료제

Article

Published on 2022-08-032022-09-11
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] administration antibody immunity Antisense oligonucleotide ASO binding complement conserved coronavirus COVID-19 COVID-19 pandemic Daily decrease disrupt Efficacy effort evade help higher infectivity human cells identify in vitro in vivo infected individuals Inhaled intranasal leader sequence lung Lungs mice new SARS-CoV-2 Non-invasive nucleic acid Pandemics Prevent preventing infection Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence severity of COVID-19 suppresse tested the SARS-CoV-2 therapeutic Therapeutic approach therapeutic strategy therapeutic targeting tide Transmission turn vaccination Vaccine variant Viral viral replication Viral RNA
[DOI] 10.1038/s41467-022-32216-0 PMC 바로가기 [Article Type] Article

Intranasal administration of a virus like particles-based vaccine induces neutralizing antibodies against SARS-CoV-2 and variants of concern

입자 기반 백신과 같은 바이러스의 비강 투여는 SARS-CoV-2 및 우려되는 변이체에 대한 중화 항체를 유도합니다.

Article

Published on 2022-08-012022-09-11
Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] administration Aerosols antibody antibody response against candidate vaccine Cell clinical trial contagious COVID-19 displaying elicited epitope evaluated help helper cell IgA antibodies IgA antibody immune response immunogenicity induce intranasal ligands local immune response lung tissue maintain Mask Masks mucosal mucosal immune murine model neutralize neutralizing antibody plasma Plasma cell platform Protective RBD RBD of SARS-CoV-2 recognize reduce required respiratory respiratory droplet Respiratory droplets SARS-CoV-2 Seven systemic and local T helper cell TLR7 TLR7/8 Transmission transmitted tropism tropism of SARS-CoV-2 Vaccine vaccine platform Vaccines variants of concern Viral viral shedding virus Virus-like particle virus-like particles VLPs VOCs
[DOI] 10.1111/all.15311 PMC 바로가기 [Article Type] Article

Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2

SARS-CoV-2에 대한 nitazoxanide의 항바이러스 활성의 전임상 평가

Article

Published on 2022-08-012022-09-11
Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] affected animal animal model antiviral activity antiviral efficacy antiviral therapy archive clinical trial Complete Concentration COVID-19 demonstrated diffusion Diseases dosage drug effective Efficacy European European Virus Archive Global Evidence evidence of France hamsters Horizon Human Human airway epithelium humans impair in vitro Infectious diseases intranasal metabolite National nitazoxanide not effective organ organs pharmacokinetic Pre-clinical research reconstructed Research SARS-CoV-2 SARS-CoV-2 virus Support supported Therapeutics tizoxanide Treatment union viral replication Wellcome Trust
[DOI] 10.1016/j.ebiom.2022.104148 PMC 바로가기 [Article Type] Article

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Research

Published on 2022-07-292022-10-05
Journal: NPJ Vaccines [Category] 비임상, 임상, 치료기술, 치료법,