Effects of the Na + /H + Ion Exchanger on Susceptibility to COVID-19 and the Course of the DiseaseReview Article Published on 2021-06-152022-10-31 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute respiratory syndrome Affect Ang II cause Cell chronic disease coronavirus disease Coronavirus-2 Course COVID-19 decrease diabetes Effect Exchanger Factor hypertension increase in increases in Increasing Infection Ion maintain mechanism novel obesity oxidative stress patients patients with COVID-19 patients with diabetes progression Prolonged reactive oxygen species reduction renin-angiotensin system SARS-CoV-2 SARS-COV-2 infection scientist susceptibility the disease [DOI] 10.1155/2021/4754440 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 complete genome sequencing from the Italian Campania region using a highly automated next generation sequencing system고도로 자동화된 차세대 시퀀싱 시스템을 사용하여 이탈리아 캄파니아 지역에서 SARS-CoV-2 완전한 게놈 시퀀싱Research Published on 2021-06-052022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 변종, [키워드] analysed automated B.1 B.1.1 Campania Campania region Complete contagiousness copy number coronavirus coronavirus genomes COVID-19 facilitate faster Genome genome sequence Genome sequencing genomic GISAID database greater Ion Ion AmpliSeq SARS-CoV-2 Research Panel IQ-TREE Italian lineages N genes Nasopharyngeal swab nasopharyngeal swabs next generation sequencing Non-synonymous non-synonymous variant nucleotide ORF1 ORF1ab ORF3a pandemic Panel positive protocol Rapid reconstruction reference strain Region reported Result RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequencing sequenced Sequencing Standardization submitted substitutions supplementary material Surveillance synonymous tested the SARS-CoV-2 genome untranslated regions UTRs Vaccines variant variants Viral viral genome Viral load viral RNA quantification viral titer virus was performed Wuhan-Hu-1 [DOI] 10.1186/s12967-021-02912-4 PMC 바로가기 [Article Type] Research
A Simple Electrostatic Precipitator for Trapping Virus Particles Spread via Droplet TransmissionArticle Published on 2021-05-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] aerosol bacteriophage φ6 Concentration coronavirus disease COVID-19 COVID-19 virus demonstrated develop droplet droplet transmission effective electric field electrostatic eliminating experiments FITC introduced Ion ionic wind negative negative charge negative ions opposite ozone bubbling pandemic Particle Particles phage provide Pseudomona respiratory droplet simple Spread Trapping vessel viral pathogen virus particle was used [DOI] 10.3390/ijerph18094934 PMC 바로가기 [Article Type] Article
Report of SARS-CoV-2 B1.1.7 Lineage in MoroccoGenome Sequences Published on 2021-04-222022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome assigned B.1.1.7 lineage coronavirus female Genetic variation genome sequence Ion Morocco N501Y mutation Nasopharyngeal swab Patient report SARS-CoV-2 Sequencing was collected was done [DOI] 10.1128/MRA.00240-21 PMC 바로가기 [Article Type] Genome Sequences
First Report of a SARS-CoV-2 Genome Sequence with a Spike His69-Val70 Deletion and an Asn439Lys Mutation in MoroccoGenome Sequences Published on 2021-03-182022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome collected Complete coronavirus Deletion described Genetic variation genome sequence Ion male Morocco nasopharyngeal swab specimen Patient report SARS-CoV-2 sequence spike was obtained [DOI] 10.1128/MRA.00027-21 PMC 바로가기 [Article Type] Genome Sequences
Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasmaResearch Article Published on 2021-03-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] active against acute respiratory syndrome antimalarial drug blood sample clinical study conditions coronavirus COVID-19 pandemic develop development Dilution emergency response ESI freeze-thaw cycles HCQ Human plasma Hydroxychloroquine injected Ion LC-MS/MS system less Liquid chromatography m/z matrix effect metabolite metabolites normalized overcome pandemic quantification quantitation ranged reported Result Sample SARS-CoV-2 selected Tandem mass spectrometry temperature Total Volume was used were used [DOI] 10.1371/journal.pone.0247356 PMC 바로가기 [Article Type] Research Article
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTPfavipiravir-RTP 존재 시 SARS-CoV-2 RNA 의존성 RNA 중합효소의 구조407 Published on 2021-02-162022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved bind binding binding pocket catalytic site clinical trial clinical trials complex conformation coronavirus COVID-19 pandemic cryoEM determine determined by develop drug Drug administration drug design drugs targeting effort enzyme Evidence explain Favipiravir FDA food help incorporation Infection information inhibitor Ion ions mechanism mechanism of action molecular basis nucleoside nucleoside analog nucleotide nucleotides polymerase polymerases RdRP Remdesivir Replication respiratory reveal RNA RNA polymerase RNA polymerase inhibitor RNA primer RNA-dependent RNA polymerase SARS coronaviruses SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus side chains Significance structural biology Structure suppresse T-705 Template the SARS-CoV-2 Treatment triphosphate US Food and Drug Administration Viral while [DOI] 10.1073/pnas.2021946118 PMC 바로가기 [Article Type] 407
Phylogenomics reveals viral sources, transmission, and potential superinfection in early-stage COVID-19 patients in Ontario, CanadaPhylogenomics는 캐나다 온타리오주에서 초기 단계의 COVID-19 환자에서 바이러스 소스, 전염 및 잠재적 중복 감염을 밝혀냅니다.Article Published on 2021-02-122022-09-01 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis Canada carried Cohort Community complement Contact tracing D614G Diseases early stages early-stage COVID-19 Effectiveness Epidemiology event Evolutionary biology filtered Genome Genome evolution GISAID database help heterozygous variant heterozygous variants IMPROVE Infectious disease International Ion limit MinION Missense Molecular epidemiology nasopharyngeal swabs Next-generation sequencing Pandemics pathogenicity Patient Phylogenetic analysis phylogenetics Phylogenomics platform Point mutation polymorphic site positive Public health intervention reveal SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequenced Sequencing Spike protein Spread Surveillance Swab synonymous variant the SARS-CoV-2 the spike protein Transmission Travel Viral viral genomes viral infection viral strain [DOI] 10.1038/s41598-021-83355-1 PMC 바로가기 [Article Type] Article
Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit530 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] activity acute respiratory syndrome antiviral drug arterivirus Cell culture cellular complex conserved Coronaviridae coronavirus Coronavirus replication Critical cytidine dependent on domain Evidence family Coronaviridae functional generate HCoV-229E homolog Hypothesis in vitro Interaction Ion M pro marker monophosphate mutant N terminus N-terminal Nidovirale nidovirus NiRAN Nsp12 nsp12 protein Nsp9 Nsps nucleotide nucleotidyltransferase observation polyprotein protease Protein proteolytic provide RdRps released Replication reported residue RNA polymerase RNA synthesis RNA viruses RNA-dependent RNA polymerase selective sequence shown Significance subunit suggested transfer transferase activity virus virus replication Vital [DOI] 10.1073/pnas.2022310118 PMC 바로가기 [Article Type] 530
Lactoferrin and Its Derived Peptides: An Alternative for Combating Virulence Mechanisms Developed by PathogensReview Published on 2020-12-082022-10-30 Journal: Molecules [Category] COVID-19, [키워드] acidic conditions addition Anti-inflammatory antibiotic antimicrobial antiviral drugs Bacteria binding Cancer cationic caused cell proliferation cell receptor colostrum develop Developed digestive disease Effect evaluate facilitate Factor fungi glycoprotein Granule growth Host immune immunoregulatory effects IMPROVE infect Infection inhibit innate immune system Interaction Invasion Ion lactoferricins lactoferrin leukocytes mammal mechanism membrane microbial mitochondrial multidrug-resistant multifunctional N-terminus parental pathogen pathogenic pathogenic bacteria pathogenicity mechanisms Pathogens peptide polymorphonuclear Prevent produced promote protease Protozoa provide Regulated cell death reported reproductive shown stimulate synergistic synthetic target toxins Treatment viral entry Viral particles virulence virulence factors virus [DOI] 10.3390/molecules25245763 PMC 바로가기 [Article Type] Review