ISG – Page 4 – Communicable Diseases Research

L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation

Immunology

Published on 2021-07-222022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus,

Potential Implications of a Type 1 Interferon Gene Signature on COVID-19 Severity and Chronic Inflammation in Sickle Cell Disease

Medicine

Published on 2021-07-222022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] adaptive airway Anti-viral anti-viral response B cell baseline bind Cell cell death chronic clinical consequence cohort of patient contribute controls COVID-19 COVID-19 progression COVID-19 severity damage-associated molecular pattern disease disparate early stage elevated epithelial Evidence Express expression General population Genes Health heme IFNAR IL-6 Immune cell independent induce Inflammation inhibit interferon interferon-stimulated gene ISG ISGs limit majority mechanism multiple study myxovirus resistance interferon stimulated genes Neutralizing antibodies neutrophil outcome pandemic Pathways Patient pattern recognition receptor Potential progression promote protective role PRRs receptor Recognition reduced released reported response responses SARS-CoV-2 SARS-COV-2 infection SCD Sickle Sickle cell disease signature stimulated Support supported susceptibility TLR4 TNFα Type type 1 interferon type 1 interferons type I interferon vascular endothelial cells viral infection viral replication Virus Disease while
[DOI] 10.3389/fmed.2021.679030 PMC 바로가기 [Article Type] Medicine

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Biochemical Techniques & Resources

Published on 2021-07-162022-10-28
Journal: Biochemical Journal [Category] COVID-19, Fulltext, SARS,

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Research Article

Published on 2021-05-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

[키워드] Adaptive immune response anti-inflammatory cytokine anti-inflammatory effect antiviral drug Asymptomatic Asymptomatic carriers CCL2 CCL3 chemokine clearance clinical manifestation Concomitant contribute correlated Cytokine storm disease driving effective elicited epithelia etiological agent expression feature high mortality Host humans IFN IL10 immune response gene immunological pathway Infection Infectious virus infiltration Inflammation Inflammatory responses innate immune response interferon interferon response interferons (IFNs ISG ISGs lethal disease leukocyte leukocytes lung MERS-CoV MERS-CoV infection Middle East Mild mucosa nasal nasal mucosa NF-κB post inoculation pro-inflammatory cytokine pro-inflammatory gene produced provoke Regulation reservoir Respiratory disease respiratory syndrome coronavirus respiratory tract Simultaneous stimulated syndrome tissue damage tissues transcribed Transcription transcriptional regulation triggering Type type I Type III IFN understanding upregulation Vaccines viral infection virus virus clearance while
[DOI] 10.1371/journal.ppat.1009229 PMC 바로가기 [Article Type] Research Article

Potential role of IFN-α in COVID-19 patients and its underlying treatment options

COVID-19 환자에서 IFN-α의 잠재적 역할 및 기본 치료 옵션

Review

Published on 2021-05-052022-09-10
Journal: Applied Microbiology and Biotechnology [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-viral Antiviral caused Combination combinations contagious coronavirus coronavirus disease Coronavirus infection correlated COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient Defense disease disease severity Diseases Diversity drug candidate drug candidates effective exacerbating expression IFN-α immunoregulatory effect immunoregulatory effects induce Infection Inflammation Inflammatory Inflammatory responses innate immune system interferon-alpha interferon-stimulated gene Intervention ISG mechanism Pathogenesis pathogenesis of SARS-CoV-2 pathogenic Patient patients with COVID-19 Point Potential PROTECT raise receptor Regulation respiratory respiratory virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severity of infection Side effect Side effects Spread subtype Therapeutic strategies therapeutic strategy treat Treatment Viral viral infection viral infections viral outbreak Virus diseases
[DOI] 10.1007/s00253-021-11319-6 PMC 바로가기 [Article Type] Review

Functional landscape of SARS-CoV-2 cellular restriction

Article

Published on 2021-04-132023-07-01
Journal: Molecular Cell [Category] SARS,

[키워드] BST2 Innate immunity interferon ISG ORF7a SARS-CoV-2 viral evasion
[DOI] 10.1016/j.molcel.2021.04.008 PMC 바로가기

Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가

Clinical Trial

Published on 2021-04-122022-08-13
Journal: Critical Care [Category] MERS, 바이오마커, 임상,

[키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN
[DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA

Article

Published on 2021-04-012023-06-09
Journal: Cellular and Molecular Immunology [Category] B형 간염, Fulltext,

[키워드] Hepatitis B virus ISG RNA degradation SAMD4 family proteins.
[DOI] 10.1038/s41423-020-0431-x PMC 바로가기

SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection

초기 비인두 감염에서 SARS-CoV-2 선천적 이펙터 연관성 및 바이러스 부하

Observational Study

Published on 2021-02-242022-09-01
Journal: Physiological Reports [Category] MERS, 임상, 진단,

[키워드] 95% CI ACE age ambulatory Antiviral antiviral gene antiviral protein antiviral responses applied association Biomarkers blocked BST cause Chain Reaction change characterized clinical outcomes clinical testing COVID‐19 cytokine Cytokines discrepancy disease disrupt early disease Effects elevated Evidence evidence of examined Host host shut‐off Hypothesis IFIT1 IFIT3 IFN IFN‐γ immune immune responses immunoassays individual Infection Inflammatory cytokines innate immune innate immune response innate immune responses Innate immunity interferon interferons ISG Modification multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Older age outcomes Patient polymerase chain polymerase chain reaction polymerase chain reaction assays Proinflammatory cytokine Protein proteomics Quantitative responses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe disease subsequent Symptom symptomatic patient systemic inflammatory tested transcribed transcript Transcription transcripts translated translation university Utah Viral viral infection Viral load widespread with infection
[DOI] 10.14814/phy2.14761 PMC 바로가기 [Article Type] Observational Study

The Fate of Speckled Protein 100 (Sp100) During Herpesviruses Infection

article

Published on 2021-02-012024-09-02
Journal: Frontiers in Cellular and Infection Microbiology [Category] 대상포진,

[키워드] epigenetics herpesviruses Immunity ISG PML-NB Sp100
[DOI] 10.3389/fcimb.2020.607526 PMC 바로가기 [Article Type] article