A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant재조합 소단위 백신은 SARS-CoV-2 P.1(감마) 변이체에 대한 원숭이에서 강력하고 광범위하게 중화되며 내구성 있는 항체 반응을 유도합니다Article Published on 2022-04-082022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anamnestic response Antigen B.1.351 B.1.617 Beta boost breadth cause circulating Concentration coronavirus CoVaccine HT cynomolgus macaques delayed challenge disease dose dosed effective Efficacy elevated evaluated Final Gamma Heterologous IgG Immunity immunization immunized immunogenic induce Infection information isolates liquid Lower respiratory tract Lung pathology lyophilized macaque macaques moderate moderate to severe mRNA natural infection Neutralizing antibodies neutralizing antibody Neutralizing antibody response P.1 pandemic potent Prevent Protective protective immunity Protein recombinant reduce Reinfection required respiratory response restored robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease significantly specific neutralizing antibodies subunit subunit protein vaccine Subunit vaccine the SARS-CoV-2 upper and lower respiratory tract Vaccine vaccine immunity variants of concern Viral Viral load viral loads VoC VOCs [DOI] 10.1021/acsinfecdis.1c00600 PMC 바로가기 [Article Type] Article
Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 20202020년 2월-6월 사이에 새로 특성화된 이탈리아 게놈을 사용한 이탈리아 및 유럽의 SARS-CoV-2 계통지리학 및 게놈 역학Article Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] adopted aims Analysis B.1 B.1.1 characterized China Cluster cluster analysis D614G variant diffusion early phase Epidemiology Europe European European country evolutionary dynamics Genome genomic isolates Italian Italian regions Italy limitation Lineage lineage B.1.1 lockdown lombardy measure new SARS-CoV-2 pandemic phylogeography Piedmont remained SARS-CoV-2 SARS-CoV-2 genomes Spread strain Veneto widespread [DOI] 10.1038/s41598-022-09738-0 PMC 바로가기 [Article Type] Article
COVID-19-associated pulmonary aspergillosis in ICU patients in a German reference centre: Phenotypic and molecular characterisation of Aspergillus fumigatus isolatesObservational Study Published on 2022-04-012022-10-05 Journal: Mycoses [Category] 임상, [키워드] A. fumigatus Analysis Aspergillus Aspergillus fumigatus azole-resistance CAPA prevalence Care caused characterisation Clustering collected Compound COVID-19 COVID-19 associated pulmonary aspergillosis Critically ill distribution Genotype genotyping hospital ICU patient increased mortality intensive care unit invasive isolate isolates marker microsatellite typing. molecular Mutation nine Patient PCR performed polyclonal Prevalence reported strain susceptibility with COVID-19 [DOI] 10.1111/myc.13430 PMC 바로가기 [Article Type] Observational Study
Variants of concern responsible for SARS-CoV-2 vaccine breakthrough infections from India인도의 SARS-CoV-2 백신 돌발 감염에 대한 우려의 변종Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] AZD1222 B.1.1.7 B.1.617.2 Breakthrough infection breakthrough infections COVID-19 Efficacy genomic Genomic analysis India isolate isolates Lineage predominant responsible SARS-CoV-2 SARS-CoV-2 vaccine Surveillance vaccination Vaccine vaccine breakthrough infections Vaccines variants variants of concern [DOI] 10.1002/jmv.27461 PMC 바로가기 [Article Type] Article
Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium사람의 기도 상피에서 SARS-CoV-2 진입 및 발아에 대한 미세구조적 통찰력Article Published on 2022-03-252022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] ACE2 airway epithelium B.1.1.7 B.1.1.7 variant budding cilia ciliary ciliated ciliated cell ciliated cells Concentration direct fusion envelope epithelial cells examined excluded explain Extracellular Genome goblet host cells Human airway epithelium Intact isolate isolates mechanism membrane membranes microvilli nucleocapsid nucleocapsids periphery plasma membrane profile profiles S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells TMPRSS2 tomography transmission electron microscopy Viral viral entry viral membrane virion virions virus [DOI] 10.1038/s41467-022-29255-y PMC 바로가기 [Article Type] Article
Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases사용 가능한 세포 프로테아제에 대한 신속한 SARS-CoV-2 적응Article Published on 2022-03-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 binding cathepsin Cathepsins cleavage clinical isolates conditions Consensus coronavirus coronavirus spike priming deep sequencing delta variant dominant Efficiency Evolution furin furin cleavage motif furin cleavage site Genome genomes genomic Genotype growth heparan sulfate highlight human cell human cells identify independent inhibit isolate isolates lack mechanism minor motif mutated Omicron variant processed protease Proteases Rapid recent S1/S2 site SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure selective sequence spike mutation spike mutation. Spike protein spike protein of SARS-CoV-2 spike variant stability subpopulation sulfate Surveillance the spike protein These cells TMPRSS2 variant variants Vero Vero E6 Vero E6 cell VERO E6 cells virus virus growth virus pathogenesis wild type [DOI] 10.1128/jvi.02186-21 PMC 바로가기 [Article Type] Article
Genomic Snapshot of SARS-CoV-2 in Migrants Entering Through Mediterranean Sea Routes지중해 항로를 통해 들어오는 이주민의 SARS-CoV-2 게놈 스냅샷Article Published on 2022-03-032022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected African Asymptomatic characterized circulating coronavirus Coronavirus pandemic country COVID-19 diffusion epidemiological epidemiological surveillance Europe European country First wave global pandemic greater Hypothesis isolate isolates Italian Italy Libyan route migrants Migration Novel coronavirus observation phylogenetically reported representing Result route Sardinia SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 surveillance SARS-CoV-2 variants sequence Sicily similarity summer Surveillance the SARS-CoV-2 genome Travel viral genome viral genomes Wuhan Wuhan, China [DOI] 10.3389/fpubh.2022.846115 PMC 바로가기 [Article Type] Article
Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제, [키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition [DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article
The changing pattern of bacterial and fungal respiratory isolates in patients with and without COVID-19 admitted to intensive care unitObservational Study Published on 2022-02-232022-10-04 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, [키워드] acute respiratory syndrome antibiotic Antimicrobial therapy Bacteria Bacterial BAL Bronchoalveolar lavage carbapenem collected Complete conducted contrary COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 positive patient Effect Enterococcus evaluate First wave fungal gram Haemophilus influenzae hospital Hospitalization Hospitalized ICU ICUs increase in Intensive intensive care intensive care unit isolate isolates Italy national health system Nurse objective observé pandemic Patient patients with COVID-19 patients without COVID-19 Period Personal protective equipment positive Prevalence profile protocol Pseudomona reduction Result retrospective SARS-CoV-2 statistically significant Streptococcus pneumoniae Surveillance tertiary referral hospital tracheal [DOI] 10.1186/s12879-022-07176-x PMC 바로가기 [Article Type] Observational Study
Improved Subtyping of Avian Influenza Viruses Using an RT-qPCR-Based Low Density Array: ‘Riems Influenza a Typing Array’, Version 2 (RITA-2)Article Published on 2022-02-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition Appropriate Avian Influenza clinical samples cross-reactions Decoupling density detect Diagnosis diagnostic Hoffmann Host IBV Improved infections Infectious Bronchitis Virus influenza A virus introduced isolates newcastle disease virus nine outbreak provide Reactions real-time RT-PCR reduced RT-PCR RT-qPCR selected sequence shown subtype typing variant Version virus Volume [DOI] 10.3390/v14020415 PMC 바로가기 [Article Type] Article