SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic PathwaysArticle Published on 2022-02-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 activate acute respiratory syndrome addition Brain brains CCL2 Central nervous system CNS Coronavirus-2 COVID-19 Culture cultures CXCL10 cytokeratin 18 promoter Effect evaluated expressing expression of gene Human human Angiotensin-converting enzyme IFN-α IL-6 Immunological response Infection Inflammation Innate immunity involved K18-hACE2 K18-hACE2 mice mechanism mice necroptosis Neuron neuronal neurons Neuropathogenesis occur Pathogenesis pathway replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection Support tissue tropism TNF-α upregulated virus replication [DOI] 10.3390/pathogens11020257 PMC 바로가기 [Article Type] Article
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infectionFc 강화 NTD 결합 비중화 항체는 바이러스 확산을 지연시키고 nAb와 상승 작용하여 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다Article Published on 2022-02-152022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ADCC Alter anti-SARS-CoV-2 antibodies antibody approach bind Combination complex contribute convalescent coronavirus COVID-19 death Efficacy epitope Evidence Fc-effector functions Fc-mediated effector function Fc-mediated effector functions function in vivo indicate K18-hACE2 K18-hACE2 mice mice Microscopy N-terminal domain NAb Neutralizing Neutralizing antibodies Non-neutralizing antibodies non-neutralizing antibody NTD overlap Prophylactic PROTECT Replication reveal SARS-CoV-2 SARS-COV-2 infection significantly spike synergy the SARS-CoV-2 virus spread [DOI] 10.1016/j.celrep.2022.110368 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models우려되는 SARS-CoV-2 변이체는 마우스 모델에서 향상된 고유 병원성 특성 및 확장된 기관 친화성을 나타냅니다.Article Published on 2022-02-152022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] accelerated ACE2 receptor Alpha Alpha variant Antibody neutralization Beta Beta variant cellular cellular immunity curtail cytokine cytokine production Depletion disease Disease progression elicit expand Gamma Gamma variant gastrointestinal tract hACE2 host range human ACE2 immune activation immune responses induce Infection Inflammation innate immune response interferon intrinsic ISG ISG expression K18-hACE2 lung Lungs management mice mouse model murine Natural killer cells neutralization organ pandemic pathogenic pathogenicity reduced replicate responses reveal SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread Symptoms systemic infection tissue transgenic Transmissibility Trigger variants variants of concern VoC VOCs wild-type zoonotic transmission [DOI] 10.1016/j.celrep.2022.110387 PMC 바로가기 [Article Type] Article
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infectionResearch article Published on 2022-02-132022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] Activation agonist Antiviral antiviral immunity antiviral response Antiviral treatment approach Brain coronavirus COVID-19 disease severity effective emerging viruses exhibited innate antiviral immunity innate immune Innate immunity K18-hACE2 K18-hACE2 mouse model Ligand lung Lung inflammation mice MT: Oligonucleotides: Therapies and Applications Neutralizing antibody response nucleic acid immunity oropharyngeal swab outcome pandemic Prophylactic PROTECT receptor reduce reduced RIG-I RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Spread survival therapeutic therapy Treatment Type I IFN type I interferon Vaccine viral challenge Viral load virus viruses [DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article
GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy InhibitionGNS561은자가 포식 억제를 통한 SARS-COV-2에 대한 강력한 항 바이러스 활성을 나타낸다.Article Published on 2022-01-122022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] accumulation activity antiviral activity autophagic autophagy blocker caused Chloroquine Compound confirmed cases coronavirus COVID-19 deaths Disruption exhibited Ezurpimtrostat GNS561 GNS561/Ezurpimtrostat hACE2 highlight Hypothesis inhibition inhibitor investigated K18-hACE2 LAMP2 LC3 lung Lungs lysosome Lysosomes mechanism pathway potent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virion SARS-CoV-2 virions Spread Support Treatment Viral viral replication viral strain [DOI] 10.3390/v14010132 PMC 바로가기 [Article Type] Article
Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2SARS-CoV-2에 감염된 K18-hACE2 마우스에 대한 멜라토닌 및 멜라토닌성 약물의 치료 가능성Article Published on 2022-01-012022-09-11 Journal: Journal of pineal research [Category] SARS, 변종, 신약개발, [키워드] administration agomelatine benefit candidate changes in Clinical outcome clinical trials Compound COVID-19 COVID-19 pandemic COVID-19 pathogenesis Cytokines Daily disease dose drug Drug repurposing drug treatment drug treatments drugs effective exacerbated expressing hACE2 human ACE2 receptor humans infected with SARS-CoV-2 Infection Inflammatory cytokine Inflammatory cytokines interferons K18-hACE2 K18-hACE2 mice limit Local lung melatonin mice Occurrence preclinical study Prophylactic ramelteon ramelteon. Safe SARS-CoV-2 SARS-COV-2 infection shown Spread survival susceptible Symptom tested therapeutic therapeutic potential treat treated Treatment type I type I and type III interferons type III Type III interferons vaccination variant [DOI] 10.1111/jpi.12772 PMC 바로가기 [Article Type] Article
Osteoclast-mediated bone loss observed in a COVID-19 mouse modelCOVID-19 마우스 모델에서 관찰된 파골세포 매개 뼈 손실Article Published on 2022-01-012022-09-11 Journal: Bone [Category] SARS, 치료기술, [키워드] added affected aging analyzed animal Asymptomatic body weight bone Bone mass consequence controls cortical cortical bone COVID-19 criteria days post infection death Decline decrease develop eight euthanized examined expressing fraction greater group groups hACE2 Health healthy help human ACE2 human disease human SARS-CoV-2 increase in increases in Infection intranasal K18-ACE2 K18-hACE2 K18-hACE2 transgenic mice knowledge mice moderate moderate disease moderate to severe Musculoskeletal Musculoskeletal health musculoskeletal system no difference no differences non-infected Osteoclasts parameter Patient plaque forming units Post-infection posture receiving reduction in remained resulting risk robust SARS-CoV-2 SARS-COV-2 infection severe disease skeletal staining TRAP treated Viral load viral loads Volume volume fraction were infected while [DOI] 10.1016/j.bone.2021.116227 PMC 바로가기 [Article Type] Article
Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M pro , Impairing Variants Replication In Vitro and In VivoArticle Published on 2021-12-242022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory syndrome administration antiretroviral assays Atazanavir B.1 lineage catalytic cell death contribute coronavirus COVID-19 demonstrated Effectiveness enzyme expression humans in vivo indicated Inflammation inhibited inhibitor inhibitory Interaction K18-hACE2 less Lineage lung M pro mechanism of action mice molecular docking pharmacokinetics positive control protease Protease inhibitor repurposing drugs SARS-CoV-2 SARS-CoV-2 main protease specific inhibitor susceptible transgenic mice treated variant [DOI] 10.3390/ph15010021 PMC 바로가기 [Article Type] Article
Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다Pathogenesis and Immunity Published on 2021-12-222022-09-10 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus viruses [DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity