Current Status and Future Perspectives on MRNA Drug ManufacturingReview Published on 2022-04-042023-07-08 Journal: Molecular Pharmaceutics [Category] COVID19(2023년), [키워드] Formulation gene delivery human clinical trials in vitro transcription Lipid nanoparticles manufacturing preclinical studies RNA scale-up Vaccines [DOI] 10.1021/acs.molpharmaceut.2c00010 PMC 바로가기 [Article Type] Review
mRNA vaccines for COVID-19 and diverse diseasesReview Published on 2022-03-212023-06-15 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 Lipid nanoparticles mRNA therapeutics mRNA vaccine SARS-CoV-2 spike-protein [DOI] 10.1016/j.jconrel.2022.03.032 PMC 바로가기 [Article Type] Review
mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in micemRNA로 인코딩된 HIV-1 Env 삼량체 페리틴 나노입자는 생쥐에서 이종 HIV-1 분리물을 중화시키는 단클론 항체를 유도합니다Article Published on 2022-03-152022-09-12 Journal: Cell Reports [Category] MERS, 진단, [키워드] acquisition antigenic autologous B cell broadly neutralizing antibodies complex COVID-19 vaccine Critical demonstrated expression ferritin Heterologous HIV-1 immunogen induce isolate knock-in mice lineages Lipid nanoparticle Lipid nanoparticles mice monoclonal antibody mRNA mRNA-LNP mutations neutralize Neutralizing Neutralizing activity neutralizing antibody nucleoside-modified mRNA precursor priming Protein Sequencing serum trimer Vaccine Vaccine development [DOI] 10.1016/j.celrep.2022.110514 PMC 바로가기 [Article Type] Article
Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory TractReview Published on 2022-02-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] acute respiratory syndrome administration advance animal model antiviral drugs Antiviral treatment approval carrier caused coronavirus COVID-19 COVID-19 disease delivery disease drug Ensuring FDA food Gene therapy globe glycogen nanoparticles inhalation limitation Lipid nanoparticles Local lung nanomedicine nanoparticle nanoparticle-capsulated drug delivery new treatment strategy organ pandemic of COVID-19 platform Polymer polymer nanoparticles provide respiratory respiratory diseases RNA SARS-CoV-2 SARS-COV-2 infection severe respiratory infections siRNA siRNAs specific tissue specific treatment Spread targeting therapeutic Therapeutics therapy tract treat variety [DOI] 10.3390/ijms23052408 PMC 바로가기 [Article Type] Review
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsReview Published on 2022-02-112022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] approval approved candidate clinically COVID-19 delivery develop disease Efficacy Emergency use evaluated gene editing genetic disease Genetic diseases global pandemic issue lesson Lipid Lipid nanoparticles LNP mRNA mRNA platform mRNA-based mRNA-based therapeutics mRNA-based vaccine mRNA-LNP nanoparticle Onpattro Pharmaceutics platform prophylactic vaccines PROTECT SARS-COV-2 infection siRNA-LNP Spread System therapeutic Therapeutics translation treat Treatment University of Pennsylvania utility Vaccine [DOI] 10.3390/pharmaceutics14020398 PMC 바로가기 [Article Type] Review
The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potencyArticle Published on 2022-02-012023-07-07 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), [키워드] immunogenicity Lipid nanoparticles Polymeric nanoparticles RNA vaccines route of administration saRNA. self-amplifying RNA Solid lipid nanoparticles [DOI] 10.1016/j.jconrel.2021.12.008 PMC 바로가기
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaquesSARS-CoV-2 백신은 유아 붉은털 원숭이에서 지속적인 면역 반응을 이끌어냅니다.Article Published on 2022-01-132022-09-12 Journal: Science Immunology [Category] MERS, SARS, 진단, [키워드] ACE2 Adults adverse effects antibody binding blocking activity cellular response Cellular responses COVID-19 decrease domain eight elicit elicited group Health IFN-γ IgG IL-17 immune function immune response immune responses Immunity immunized immunogenic immunogenicity Impact Inclusion Infant Infants intramuscularly limit Lipid nanoparticle Lipid nanoparticles magnitude memory B cell memory B cells mitigate Moderna mRNA-1273 vaccine mRNA neutralizing antibody titers novel vaccines peaking pediatric prefusion Prevent proof proof of concept Protein purified RBD rhesus macaque S protein S-2P S1 and S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe complication severe complications squalene T cell T cell response the SARS-CoV-2 TLR7 TLR7/8 TNF-α Transmission transmission of SARS-CoV-2 two groups Vaccine [DOI] 10.1126/sciimmunol.abj3684 PMC 바로가기 [Article Type] Article
Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs3 개의 승인 된 siRNA (Patisiran) 및 mRNA (COVID-19 백신) 약물에 사용 된 지질 나노 입자 기술의 차이Review Published on 2021-12-012022-08-31 Journal: Drug metabolism and pharmacokinetics [Category] MERS, 치료제, [키워드] approval approved approved drug biodistribution Candidates coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine moderna difference drug drugs effective delivery Elasomeran Genes Ionizable lipid Lipid Lipid nanoparticles LNP Medicine Moderna mRNA mRNA vaccine mRNA vaccines mRNA-based Onpattro outbreak Patisiran Pfizer-BioNTech provided remained Safe SARS-CoV-2 siRNA target cell target cells Tozinameran translation [DOI] 10.1016/j.dmpk.2021.100424 PMC 바로가기 [Article Type] Review
Specific delivering of RNAi using Spike’s aptamer‐functionalized lipid nanoparticles for targeting SARS‐CoV‐2: A strong anti‐Covid drug in a clinical case studyCase Report Published on 2021-11-242023-06-15 Journal: Chemical biology & drug design [Category] COVID19(2023년), MERS, SARS, [키워드] Antiviral aptamer inhalation Lipid nanoparticles RNAi SARS‐CoV‐2 [DOI] 10.1111/cbdd.13978 PMC 바로가기 [Article Type] Case Report
The Critical Contribution of Pseudouridine to mRNA COVID-19 VaccinesCell and Developmental Biology Published on 2021-11-042022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] clinical trial COVID-19 COVID-19 case COVID-19 mRNA vaccines COVID-19 pandemic COVID-19 vaccine Critical death effective Efficacy feature FIVE highlight Lipid nanoparticles LNP Moderna mRNA mRNA vaccine mRNA vaccines N1-methyl-pseudouridine pandemic Pfizer-BioNTech presenting Protein pseudouridine RNA modification SARS-CoV-2 sequence spike Spike protein suggested Therapeutics Vaccine Vaccines [DOI] 10.3389/fcell.2021.789427 PMC 바로가기 [Article Type] Cell and Developmental Biology