Coagulation System Activation for Targeting of COVID-19: Insights into Anticoagulants, Vaccine-Loaded Nanoparticles, and Hypercoagulability in COVID-19 VaccinesReview Published on 2022-01-242022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Anticoagulant anticoagulant agent anticoagulant therapy Anticoagulants Blood coagulation Coagulation system Coagulopathy Complication complications coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cytokine Cytokine storm D-dimer Degradation drugs elevated help hypercoagulability immune Infection Inflammation insight life-threatening lower mortality mitigate Mortality Nanoparticles natural anticoagulants organ damage outbreak overlap Patient poor prognosis Prevalence Research responsible SARS-CoV-2 severe COVID-19 Side effect symptoms of COVID-19 syndrome System targeting thrombosis Treatment with COVID-19 worldwide pandemic [DOI] 10.3390/v14020228 PMC 바로가기 [Article Type] Review
Clinical efficacy of iodine complex in SARS-CoV-2-infected patients with mild to moderate symptoms: study protocol for a randomized controlled trial경증에서 중등도의 증상을 보이는 SARS-CoV-2 감염 환자에서 요오드 복합체의 임상 효능: 무작위 대조 시험을 위한 연구 프로토콜Update Published on 2022-01-192022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] adaptive addition alleviate analyzed Arm benefit both groups caused Chest clinic clinical clinical trial collected Combination complex Computed tomography conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 patient COVID-19 patients doctor Efficacy High-resolution Hospitalization HRCT implication IMPROVE in both groups Intervention Iodine lower mortality Mild mild to moderate mild to moderate symptoms moderate Mortality Novel coronavirus pandemic parallel group parameter Patient Placebo placebo-controlled Polymer questionnaire radiological improvement Randomized controlled trial randomized trial receive reduction in respiratory respiratory syndrome coronavirus RT-PCR Sample size SARS-CoV-2 SARS-CoV-2-infected patient SAS version 9.4 severe respiratory syndrome socioeconomic status standard care Study protocol symptomatic Symptoms syrup Treatment treatment of COVID-19 Trial Trial registration Viral Viral load viral load reduction with COVID-19 written consent [DOI] 10.1186/s13063-021-05848-8 PMC 바로가기 [Article Type] Update
Interleukin-37: A Link Between COVID-19, Diabetes, and the Black FungusMicrobiology Published on 2022-01-132022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] black Comorbidity coronavirus disease Corticosteroids COVID-19 COVID-19 pandemic COVID-19 patients cytokine diabete diabetes Diabetic dysregulated immune response Fungal infection fungus hospitals IL-1 IL-37 immune responses Infection Inflammation Initiation invasive involved lack lower mortality Mucormycosis oxygen Patient reduce reducing secondary infections severe COVID-19 systemic corticosteroid T2D use of corticosteroid [DOI] 10.3389/fmicb.2021.788741 PMC 바로가기 [Article Type] Microbiology
Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation RegistryObservational Study Published on 2022-01-012022-10-04 Journal: Heart (British Cardiac Society) [Category] 임상, [키워드] 95% CI anticoagulation antiplatelet Aspirin bleeding clinical consecutive patient COVID-19 diabete drugs Efficacy embolic enrolled evaluate event hospitalisation hospitalised patient In-hospital in-hospital complication in-hospital mortality increased risk International invasive ventilation lower mortality lower mortality risk male mechanical ventilation microthrombi multicentre multivariable analysis no difference Older organs outcome Patient Pharmacology Prevalence registry risk Standard survival therapy therapy for COVID-19 treated were recorded with COVID-19 [DOI] 10.1136/heartjnl-2021-319552 PMC 바로가기 [Article Type] Observational Study
Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions – Exploring the impact of treatment and strain dynamicsCOVID-19 입원의 임상 특성 및 결과의 웨이브 비교 - 치료 및 변형 역학의 영향 탐색Observational Study Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 바이오마커, 변종, 임상, 치료법, [키워드] Characteristics Clinical characteristics Cohort cohorts comparison COVID-19 COVID-19 admission COVID-19 patient COVID-19 variants COVID-19 waves death Dexamethasone disease dominant Evidence Factor highlight Highlights hospital Impact improvement intensive care Intervention lower mortality Mortality not significantly different observational study outcome Patient patients Research retrospective risk Standard of care Support Treatment Trial variants Wave [DOI] 10.1016/j.jcv.2021.105031 PMC 바로가기 [Article Type] Observational Study
Comparison of demographic and clinical characteristics of hospitalized COVID-19 patients with severe/critical illness in the first wave versus the second wave1차 유행과 2차 유행의 중증/중증 질환으로 입원한 COVID-19 환자의 인구통계학적 및 임상적 특성 비교Observational Study Published on 2022-01-012022-09-12 Journal: Journal of medical virology [Category] SARS, 임상, 진단, [키워드] Admission age Analysis C-reactive protein (CRP changed characteristics of patient Chronic kidney disease Clinical characteristics Comorbidities coronavirus COVID-19 COVID-19 patient Critical database demographic characteristics demographics expected First wave Follow-up Gender group hospital hospitalization criteria hospitalized COVID-19 patient hospitalized COVID-19 patients intensive care interquartile range laboratory-confirmed lower mortality management Mortality mortality rate occurred outcome Patient Previous studies reported second wave serum CRP significantly higher the first versus second wave. Turkey was performed WHO World Health Organization [DOI] 10.1002/jmv.27319 PMC 바로가기 [Article Type] Observational Study
The Use of Corticosteroids or Tocilizumab in COVID-19 Based on Inflammatory Markers염증 표지자를 기반으로 한 COVID-19에서의 코르티코스테로이드 또는 토실리주맙의 사용Article Published on 2022-01-012022-09-11 Journal: Journal of General Internal Medicine [Category] SARS, 바이오마커, 진단, [키워드] administer Admission C-reactive protein cause of death collected Combination Corticosteroids COVID-19 COVID-19 patients CRP D-dimer values death in COVID-19 Efficacy Escalation evaluate ferritin HFNC high risk High-flow nasal cannula Hospital mortality ICU IMV in-hospital mortality inclusion criteria Inflammation inflammatory cascade intensive care intensive care unit Invasive mechanical ventilation Lactate lactate dehydrogenase LDH lower mortality lymphocyte Lymphocyte count mechanical ventilation Mortality nasal nasal cannula NIMV no significant differences Non-invasive non-invasive mechanical ventilation outcome Patient patients prescription Primary outcome propensity score matching registry retrospective cohort study Risk category secondary Secondary outcomes significant difference Spanish statistically significant TCZ therapy Tocilizumab treat treated Treatment [DOI] 10.1007/s11606-021-07146-0 PMC 바로가기 [Article Type] Article
BNT162b2 Vaccine Booster and Mortality Due to Covid-19BNT162b2 백신 부스터 및 Covid-19로 인한 사망률Article Published on 2021-12-232022-09-11 Journal: The New England Journal of Medicine [Category] 변종, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted hazard ratio age approved association B.1.617.2 BNT162b2 BNT162b2 vaccine booster conditions coronavirus coronavirus disease Coronavirus disease 2019 covariate death dose Effectiveness eligibility criteria lower mortality Ministry of Health Mortality occurred of BNT162b2 Older participant per day Pfizer-BioNTech Population receive reduced Regression model resurgence second dose service severe acute respiratory syndrome Coronavirus Sociodemographic factor sociodemographic factors study period variant was used [DOI] 10.1056/NEJMoa2115624 PMC 바로가기 [Article Type] Article
Outcomes of patients with severe and critical COVID-19 treated with dexamethasone: a prospective cohort studyCoronaviruses Published on 2021-12-212022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] 95% CI Analysis association cohort study conducted Corticosteroid corticosteroid treatment Corticosteroids COVID-19 Critical death Dexamethasone evaluate groups HAI Hospital-acquired infection Hospitalization implementation IMV in-hospital mortality independent Invasive mechanical ventilation less LOS lower mortality management median time Mexico Multivariate analysis occurred outcome Patient patients performed Primary outcome prospective cohort study reduced SARS-CoV-2 secondary treated [DOI] 10.1080/22221751.2021.2011619 PMC 바로가기 [Article Type] Coronaviruses
Systemic Anti-Cancer Therapy and Metastatic Cancer Are Independent Mortality Risk Factors during Two UK Waves of the COVID-19 Pandemic at University College London HospitalArticle Published on 2021-12-022022-10-31 Journal: Cancers [Category] COVID-19, [키워드] age Alpha variant Analysis anti-cancer treatment anti-cancer treatments association B.1.1.7 B.1.1.7 SARS-CoV-2 variant Cancer co-morbidities co-morbidity Cohort COVID-19 COVID-19 hospitalization COVID-19 in patient COVID-19 pandemic death demographics demonstrated determinant determine Effect evaluated Factor First wave hospital hospitalized patients Immunosuppression increased mortality increased risk independent risk factor London lower mortality metastatic metastatic cancer metastatic disease Mortality outcome Patient patients treated Patients with cancer presenting Retrospective analysis risk risk factor Risk factors SARS-COV-2 infection second wave simple solid cancer systemic systemic anti-cancer therapy United Kingdom University College London variable was performed Wave with COVID-19 [DOI] 10.3390/cancers13236085 PMC 바로가기 [Article Type] Article