S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies
Research Article
[키워드] acute respiratory syndrome
Antiviral
antiviral activity
assist
association
binding
broad inhibitor
C-terminal
C-terminal region
catalytic site
catalytically
caused
cofactor
complex
coronavirus
CpG
cysteine
cytoplasm
Degradation
dependent on
determinant
dinucleotide
distribution
domain
element
Endoplasmic reticulum
Factors
highlight
HIV-1
Human immunodeficiency virus
hydrophobic
in viral
inactive
Interaction
isoform
KHNYN
lack
membrane
membranes
Microscopy
modulate
motif
N-terminal RNA-binding domain
nucleus
PARP
physical
plasma membrane
polymerase
post-translational modification
Prevent
Protein
provide
recruitment
regulate
replicate
Replication
required
residue
restored
RNA
RNA virus
RNAs
SARS-CoV-2
Structure
subcellular
translation
TRIM25
type I
Vesicle
viral pathogens
Viral RNA
virion
virus
virus replication
ZAP
[DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article