Estimation of basic reproduction number of the Middle East respiratory syndrome coronavirus (MERS-CoV) during the outbreak in South Korea, 2015Research Published on 2017-06-132022-10-28 Journal: BioMedical Engineering OnLine [Category] Coronavirus, [키워드] average basic reproduction number basic reproductive number Characteristics condition CoV defined determine early phase Ebola Epidemic estimate estimation evaluate fluctuation identify Infection Intervention Liberia mathematical MERS MERS coronavirus MERS coronavirus (MERS-CoV) MERS-CoV Middle East Middle East respiratory syndrome (MERS) occurred outbreak parameter parameters patients died problem reported respiratory syndrome coronavirus Result secondary case South Korea Spread subject susceptible Susceptible-infected-removed (SIR) model Symptoms syndrome the epidemic uninfected West [DOI] 10.1186/s12938-017-0370-7 PMC 바로가기 [Article Type] Research
Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome CoronavirusResearch Article Published on 2017-04-042022-10-29 Journal: mBio [Category] Coronavirus, [키워드] Amino acid amino acid substitution Analysis approach bat binding clone competent coronavirus CoV Critical current described determine DPP4 driving ecological effort epithelial cells Evidence Evolution Express expressing Factor functional Genome humans Hypothesis identity infect infect cell Infection investigated MERS MERS coronavirus MERS-CoV Middle East novel virus pandemic phenotype Pipistrellus predicted primary human airway primary mechanism receptor Receptor binding recombinant Recombination Replication residue respiratory risk sequence Source spike spike gene Spike protein Spread Surveillance syndrome the S1 subunit the spike protein Uganda unlikely Variation Vero Cell Vespertilionidae virus viruses zoonoses zoonotic zoonotic threat [DOI] 10.1128/mBio.00373-17 PMC 바로가기 [Article Type] Research Article
Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015Research Article Published on 2017-03-302022-10-31 Journal: Eurosurveillance [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] 95% confidence interval blood sample condition density detection rate Factor herd size humans identify Infection MERS coronavirus MERS-CoV MERS-CoV infection MERS-CoV RNA Middle East milking activities Morocco nasal swab nomadic raised respiratory syndrome coronavirus risk factor RNA sedentary Seropositivity Transmission Transport understanding West - East gradient zoonotic [DOI] 10.2807/1560-7917.ES.2017.22.13.30498 PMC 바로가기 [Article Type] Research Article
Middle East Respiratory SyndromeArticle Published on 2017-03-212022-11-01 Journal: The New England Journal of Medicine [Category] Coronavirus, [키워드] antiviral therapy approach Arabian Peninsula Asymptomatic binding Care caused CEACAM5 Cluster cofactor country deaths developmental Diagnosis Dipeptidyl peptidase 4 disease pathogenesis Dromedary Efficacy Evolution Health high mortality host cell Human human respiratory epithelium human-to-human transmission hypoxemic illness Incubation period Infection knowledge laboratory-confirmed Ligand Lower respiratory tract MERS MERS coronavirus MERS-CoV MERS-CoV infection Middle East mild case Multiorgan occur Occurrence outbreak Patient receptor regions replicate respiratory Respiratory failure RT-PCR Saudi Arabia secretion seriously ill patients Support syndrome Transmission Treatment Vaccine virus WHO World Health Organization zoonotic infection [DOI] 10.1056/NEJMsr1408795 PMC 바로가기 [Article Type] Article
Livestock Susceptibility to Infection with Middle East Respiratory Syndrome CoronavirusResearch Published on 2017-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] animal model antibody circulation collected coronavirus determine develop Dipeptidyl peptidase-4 DPP4 Evidence horse immunohistochemistry Infection Infectious virus inoculated livestock llama MERS MERS coronavirus MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome nasal PCR pig rectal swab reported reservoir reservoirs respiratory Saudi Arabia Seroconversion sheep susceptibility susceptible syndrome upper respiratory tract viral replication viruses [DOI] 10.3201/eid2302.161239 PMC 바로가기 [Article Type] Research
Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective studyResearch Article Published on 2017-01-052022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] affected Care Chi-square clinical manifestation Clinical presentations Comorbidities Comorbidity comparative statistics Confirmed confirmed case cough dead demographic characteristics Dromedary Epidemic Epidemiology exceeded Factor female patient Fever Frequency Health Human identify implicated IMPROVE Infection information laboratory-confirmed majority male men MERS MERS coronavirus MERS-CoV Middle East Middle East respiratory syndrome Ministry of Health Mortality mortality rate outbreak Patient performed reported required respiratory syndrome coronavirus Result Retrospective study route of infection Saudi Arabia Shortness of breath Surveillance syndrome the patient Transmission WHO women zoonotic disease [DOI] 10.1186/s12879-016-2137-3 PMC 바로가기 [Article Type] Research Article
An assessment of the level of concern among hospital-based health-care workers regarding MERS outbreaks in Saudi ArabiaResearch Article Published on 2017-01-032022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] addition addressed Affect affected age Attitude average calculated Care caused concern covariates disease distinct domains Effectiveness effort evaluated FIVE Government HCW HCWs health-care health-care worker hospital hospitals identify majority management MERS MERS coronavirus MERS-CoV MERS-CoV infection Middle East Mortality Multiple National Nurses occurred outbreak outcome participant Patient precautions predictor questionnaire regression analysis reported respiratory Result risk Safe Saudi Arabia severity significantly the disease Travel virus were assessed were used [DOI] 10.1186/s12879-016-2096-8 PMC 바로가기 [Article Type] Research Article
Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab EmiratesOriginal Article Published on 2016-12-212022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] amino acid substitutions Analysis circulating clade clade A Complete dead demonstrated dromedary camels Evidence Genome Human isolate Isolation knowledge Lineage MERS MERS coronavirus MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Molecular epidemiology nine novel ORF1ab Phylogenetic polyphyletic predicted protein sequence Recombination Region respiratory syndrome coronavirus Saudi Arabia sequenced strain Strains Support TMRCA unique United Arab Emirate United Arab Emirates [DOI] 10.1038/emi.2016.129 PMC 바로가기 [Article Type] Original Article
Knowledge, Attitudes and Behaviours of Healthcare Workers in the Kingdom of Saudi Arabia to MERS Coronavirus and Other Emerging Infectious DiseasesArticle Published on 2016-12-062022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, [키워드] Anxiety Asymptomatic Attitude Attitudes Behaviours coronavirus described Descriptive statistics Diseases Emerging infectious diseases HCW HCWs health care workers healthcare worker Infection infection control Infectious disease information investigated Isolation Kingdom knowledge Measures MERS MERS coronavirus MERS-CoV Middle East Ministry of Health Nurse objective Other outbreak patients Personal protective equipment Physicians Practice psychological problem questionnaire reported respiratory responses Result risk Saudi Arabia was used worker [DOI] 10.3390/ijerph13121214 PMC 바로가기 [Article Type] Article
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccinesArticle Published on 2016-11-222022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] determine Du et al effective Efficacy elicit eliminated epitope evaluate host immune responses immune responses immunodominant life-threatening MERS coronavirus MERS-CoV Neutralizing non-neutralizing epitope probe significantly subunit Subunit vaccine the receptor-binding domain the vaccine transgenic mice Vaccine Vaccine design variant viruses [DOI] 10.1038/ncomms13473 PMC 바로가기 [Article Type] Article