metabolite
[대역어] 대사산물
[용어속성] Term
[용어속성] Term
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients
혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다
Article
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단,
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단,
[키워드] accumulated
Accuracy
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
alteration
antibody
association
catalyzed
cleavage
conducted
convalescent
convalescent COVID-19 patient
convalescent COVID-19 patients
convalescent patient
Convalescent patients
coronavirus
COVID-19
COVID-19 convalescent patients
COVID-19 pandemic
cytokine
cytokine profile
cytokine profiling
Cytokines
demonstrated
dipeptide
dipeptidyl peptidase
Dipeptidyl peptidase 4
domain
down-regulate
DPP4
experiment
feature
Feature selection
glycylproline
healthy
healthy subjects
IL-12p40
immune response
immune responses
individual
inhibitor
inhibitory effect
Inhibitory effects
M-CSF
machine-learning
mechanism
metabolite
metabolites
metabolome
metabolomics
mice
modulating
neutralizing antibody
outcome
peptide
plasma
Plasma cytokine
product
public health
Quantitative
respiratory
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 vaccination
severe acute respiratory syndrome Coronavirus
sitagliptin
suppresse
therapeutic
Treatment
vaccination
Vaccination strategy
with COVID-19
[DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
[DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients
Research
[키워드] Amino acid
Analysis
concentrations
continuous monitoring
detect
facilitate
generate
health condition
metabolite
Non-invasive
physical
Polymer
Precision
Real-time monitoring
reporter
risk
serum
Sweat
syndrome
vitamins
volunteers
[DOI] 10.1038/s41551-022-00916-z [Article Type] Research
[DOI] 10.1038/s41551-022-00916-z [Article Type] Research
A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers
인간 혈장에서 항 바이러스 전구 약물 Molnupiravir의 결정을위한 검증 된 LC-MS/MS 방법 및 건강한 이집트 자원 봉사자들의 약동학 적 모델링 연구에 대한 적용
Article
Published on
Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제,
Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제,
[키워드] acetic
acetic acid
acetonitrile
Agilent
analyte
analyzed
Antiviral
approach
AUC
C max
Concentration
confidence interval
detection
determine
develop
dosage
dose
Eclipse
Efficacy
ESI
evaluate
extraction
FDA
flow rate
geometric mean
geometric mean ratios
Geometric means
GMR
Guidance
healthy
healthy volunteer
healthy volunteers
Human plasma
LC-MS/MS
Linear regression
linearity
m/z
mass spectrometer
mass spectrometry
maximum concentration
metabolite
mixture
molnupiravir
N-hydroxycytidine
NHC
pharmacokinetic
pharmacokinetic data
plasma
Population
Population Pharmacokinetic Modeling
positive
protein precipitation
pumped
recommendation
required
ribavirin
SARS-CoV-2
Simulation
solvent
subjects
therapeutic target
therapeutic targets
Treatment
triple quadrupole mass spectrometer
United State
United States
Volunteer
was performed
was used
were used
[DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approach
SARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근
Article
[키워드] 3CLpro
accelerate
accession number
aligned
ammonia
analyses
Analysis
analyzed
antioxidant
approach
associations
Bacillus
Bacteria
Bacterial
biochemically
chymotrypsin
Chymotrypsin-like protease
collected
Compound
computational tool
coronavirus
Culture
docked
docking scores
drug-likeness
effective
enzyme
flask culture
flavonoid
GenBank
identify
in silico analysis
in-silico
inhibitor
Interaction
isolate
Lopinavir
metabolite
metabolites
Micrococcus
morphologically
nine
NMR
nucleotide
nucleotide sequence
outcome
performed
phytohormone
plant
profiles
protease
protein-protein network
protein-protein networks
protocol
Pseudomonas species
rDNA
reported
Research
Sanger sequencing
Secondary Metabolite
sequence similarity
Staphylococcus
structures
submission
target protein
target proteins
tested
these compounds
was performed
were assessed
[DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
[DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning
Research article
Published on
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, 치료기술,
[키워드] BSAbovine serum albumin COVID-19
Dickinson and Company
3-nitrophenylhydrazine
AAAamino acid analysis
Accuracy
ACDacid citrate dextrose
acetonitrile
acid citrate dextrose
ACNacetonitrile
Alpha 1-antichymotrypsin
Alpha-1-antichymotrypsin
amino acid analysis
analysis of variance
ANOVAanalysis of variance
APCS
APOA2
APOA4
APOH Beta-2-glycoprotein 1
Apolipoprotein A-IIAPOA4
Apolipoprotein A-IVAPOH Beta-2-glycoprotein 1
area under the curve
AUC
AUCarea under the curve
B2MBeta-2-microglobulin
BDBecton
Becton
Beta-2-microglobulin
BHTbutylated hydroxyl toluene
bovine serum albumin COVID-19
BQC19
building
butylated hydroxyl toluene
C-reactive protein
C1RLComplement C1r subcomponent-like protein
C2Complement C2
C3Complement C3
C4AComplement C4
C4b-binding protein alpha chain
C4BPAC4b-binding protein alpha chain
C5Complement C5
C7Complement C7
C9Complement C9
CAMPCathelicidin antimicrobial peptide
capillary zone electrophoresis
Carboxypeptidase B2
Cathelicidin antimicrobial peptide
CFBComplement factor B
CFHComplement factor H
Clinical Proteomic Tumor Analysis Consortium
Coagulation factor XIII A chain
Complement C1r subcomponent-like protein
Complement C2
Complement C3
Complement C4
Complement C5
Complement C7
Complement C9
Complement factor B
Complement factor H
Concentration
concentrations
Control
COVID-19 hospitalization
COVID-19 patient
CPB2Carboxypeptidase B2
CPTACClinical Proteomic Tumor Analysis Consortium
CRPC-reactive protein
CST3Cystatin-C
Cystatin-C
CZEcapillary zone electrophoresis
disease severity
dithiothreitol
DTTdithiothreitol
ECMOextracorporeal membrane oxygenation
extracorporeal membrane oxygenation
F13A1Coagulation factor XIII A chain
FAFormic acid
false discovery rate
FDRfalse discovery rate
FGAFibrinogen alpha chain
FGBFibrinogen beta chain
FGGFibrinogen gamma chain
Fibrinogen alpha chain
Fibrinogen beta chain
Fibrinogen gamma chain
FIVE
Formic acid
Gelsolin
Gene name /Protein nameAPCS
globe
GSNGelsolin
haptoglobin
Healthcare system
Heparin cofactor 2
Hospitalization
hospitalized COVID-19 patients
HPhaptoglobin
IAAiodoacetamide
ICUIntensive Care Unit
IGFALSInsulin-like growth factor-binding protein complex acid labile subunit
Insulin-like growth factor-binding protein complex acid labile subunit
intensive care unit
Inter-alpha-trypsin inhibitor heavy chain H2
Inter-alpha-trypsin inhibitor heavy chain H4
iodoacetamide
ITIH2Inter-alpha-trypsin inhibitor heavy chain H2
ITIH4Inter-alpha-trypsin inhibitor heavy chain H4
K3EDTAtripotassium ethylenediaminetetraacetic acid
L-(tosylamido-2-phenyl) ethyl chloromethyl ketoneTrisHCl
LC-MSliquid chromatography-mass spectrometry
LC/MRM-MSliquid chromatography/multiple reaction monitoring mass spectrometry
Leucine-rich alpha-2-glycoprotein
liquid chromatography-mass spectrometry
liquid chromatography/multiple reaction monitoring mass spectrometry
LLOQLower Limit of Quantitation
Lower Limit of Quantitation
LRG1Leucine-rich alpha-2-glycoprotein
lysoPClysophosphatidylcholine
lysophosphatidylcholine
MALDImatrix assisted laser desorption ionization
mass spectrometry
matrix assisted laser desorption ionization
MeOHmethanol
metabolite
methanol
Mortality
MSmass spectrometry
N-acetylmuramoyl-L-alanine amidase
Neuropilin-2
Non-survivors
NPH3-nitrophenylhydrazine
NRP2Neuropilin-2
patient survival
PBSPhosphatase buffered saline
PCAprincipal component analysis
PCRpolymerase chain reaction
PGLYRP2N-acetylmuramoyl-L-alanine amidase
phenylisothiocyanate
Phosphatase buffered saline
PITCphenylisothiocyanate
plasma
polymerase chain reaction
post-translational modification
predict
Predictive
PRG4Proteoglycan 4
principal component analysis
PROS1Vitamin K-dependent protein S
Protein
Proteoglycan 4
PTMpost-translational modification
QCquality control
Quality control
reversed phase ultrahigh performance liquid chromatography
robust
RP-UHPLCreversed phase ultrahigh performance liquid chromatography
SAA2Serum amyloid A-1 and A-2 proteins
SAA4Serum amyloid A-4 protein
SARS-CoV-2SIS
Scientific and Cultural Organization
Sequential Organ Failure AssessmentSPE
SERPINA1Alpha-1-antichymotrypsin
SERPINA3Alpha 1-antichymotrypsin
SERPIND1Heparin cofactor 2
Serum amyloid A-1 and A-2 proteins
Serum amyloid A-4 protein
Serum amyloid P-componentAPOA2
significant difference
SIS
SOFA
solid-phase extractionSVM
SPE
stable-isotope labeled internal standardSOFA
Stratification
Support Vector MachineTPCK
survival
survivor
SVM
The Universal Protein Resource
TPCK
Transthyretin
Treatment
tripotassium ethylenediaminetetraacetic acid
Tris (hydroxymethyl) aminomethane hydrochlorideUNESCO
TrisHCl
TTRTransthyretin
UNESCO
UniProtThe Universal Protein Resource
unique
United Nations EducationalScientific and Cultural Organization
Vascular cell adhesion protein 1
VCAM1Vascular cell adhesion protein 1
Vitamin K-dependent protein S
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
[DOI] 10.1016/j.mcpro.2022.100277 [Article Type] Research article
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress
진단 후 6개월째 COVID-19 생존자의 심리적 결과: 우울증, 불안 및 스트레스에서 키누레닌 경로 대사물의 역할
Article
[키워드] 3-hydroxykynurenine
Activation
Admission
alteration
Anxiety
anxiety symptom
Biomarker
Biomarkers
both groups
center
change
coronavirus disease
Coronavirus disease 2019
correlation
COVID-19
DASS-21
Depression
depressive
Depressive symptoms
exhibited
Follow-up
healthy control
healthy controls
Hospitalization
illnesses
immune response
immunologic response
in both groups
increase in
Inflammation
initial
initial assessment
Kynurenic acid
Kynurenine
Kynurenine pathway
leads
life
mechanism
Mental
metabolism
metabolite
outcome
pandemic
participant
pathophysiology
pathway
plasma
Plasma levels
post-COVID-19 patient
Post-COVID-19 patients
predicted
predictor
Psychiatric
psychiatric disorder
Psychiatric disorders
questionnaire
reduction in
Stress
Stress Scale
survivor
Symptom
target
therapy
to define
TRP
Tryptophan
Viral
viral infection
viral infections
virus
was used
with COVID-19
[DOI] 10.1007/s00702-022-02525-1 PMC 바로가기 [Article Type] Article
[DOI] 10.1007/s00702-022-02525-1 PMC 바로가기 [Article Type] Article
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2
SARS-CoV-2에 대한 nitazoxanide의 항바이러스 활성의 전임상 평가
Article
[키워드] affected
animal
animal model
antiviral activity
antiviral efficacy
antiviral therapy
archive
clinical trial
Complete
Concentration
COVID-19
demonstrated
diffusion
Diseases
dosage
drug
effective
Efficacy
European
European Virus Archive Global
Evidence
evidence of
France
hamsters
Horizon
Human
Human airway epithelium
humans
impair
in vitro
Infectious diseases
intranasal
metabolite
National
nitazoxanide
not effective
organ
organs
pharmacokinetic
Pre-clinical research
reconstructed
Research
SARS-CoV-2
SARS-CoV-2 virus
Support
supported
Therapeutics
tizoxanide
Treatment
union
viral replication
Wellcome Trust
[DOI] 10.1016/j.ebiom.2022.104148 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ebiom.2022.104148 PMC 바로가기 [Article Type] Article
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir
Article
[키워드] Antiviral
antiviral efficacy
catalyzed
cells
cellular
Concentration
decrease
demonstrated
Efficiency
endogenous enzyme
expressed
form
hydrolase
hydrolysis
hydrolyzed
limit
metabolite
molnupiravir
notable
nucleoside analog
nucleotide
nucleotide hydrolysis.
NUDIX hydrolase
NUDT18
occur
Remdesivir
respiratory epithelial cells
ribavirin
SARS-CoV-2
SARS-CoV-2 replication
tested
was determined
[DOI] 10.1016/j.jbc.2022.102169 PMC 바로가기
[DOI] 10.1016/j.jbc.2022.102169 PMC 바로가기
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
SARS-CoV-2 바이러스 NSP14는 Sirtuin 1을 표적으로 하여 NRF2/HMOX1 활성화를 손상시킵니다
Article
Published on
Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,
Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,
[키워드] activate
Activation
acute respiratory distress
acute respiratory distress syndrome
antioxidant defense system
antiviral activity
ARDS
Biliverdin
catalytic domain
cell type
COVID-19 pandemic
Cytokine storms
death
Defense
Evidence
Factor
Genetic
HMOX1
Host
host defense
inhibit
interact
mechanism
metabolite
MOST
Nrf2
nsp14
oxidative stress
pathway
producing
regulated
respiratory distress
Respiratory failure
Respiratory virus infections
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 replication
SARS-CoV-2 virus
significantly
SIRT1
sirtuin
suppressed
syndrome
Viral protein
[DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41423-022-00887-w PMC 바로가기 [Article Type] Article