Mucormycosis (black fungus) ensuing COVID-19 and comorbidity meets – Magnifying global pandemic grieve and catastrophe beginsCOVID-19에 뒤이은 진균증(검은 곰팡이)과 동반 질환이 만나다 - 확대되는 세계적 대유행 비탄과 재앙이 시작됨Review Published on 2022-01-202022-09-11 Journal: The Science of the total environment [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] analysed article Asian association associations Awareness biochemical pathway Biochemical pathways Case report case reports clinical manifestation cohorts Comorbidity counter country COVID COVID-19 COVID-19 induced Mucormycosis Dexamethasone diabetes Diabetes Mellitus Diagnosis Drug administration elevated Genetic genetic mechanism global pandemic human population hyperglycemia immune Immunosuppression India Infection infections Intention iron Ketosis meet Mild modulated Mucormycosis occurred pandemic Pathogenesis predisposing factor reason for receptor reported robust secondary secondary infections serum severe COVID-19 steroid steroid therapy Survivors the SARS-CoV-2 therapy [DOI] 10.1016/j.scitotenv.2021.150355 PMC 바로가기 [Article Type] Review
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Rapid and accurate clinical testing for COVID-19 by nicking and extension chain reaction system-based amplification (NESBA)NESBA(Nicking and Extension Chain Reaction System-Based Amplification)를 통한 신속하고 정확한 코로나19 임상시험Article Published on 2022-01-152022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy amplification applied Chain Reaction clinical sample clinical samples clinical sensitivity clinical testing COVID-19 detect Diagnosis diagnostics DNA double-stranded Double-stranded DNA extension genomic RNA gRNA identify isothermal isothermal amplification large cohort modulated molecular multiplex N gene NASBA NESBA nucleocapsid platform POC point-of-care primer Primers qRT-PCR Rapid RNA SARS-CoV-2 SARS-CoV-2 viral RNA sequence specificity temperature Viral yielding [DOI] 10.1016/j.bios.2021.113689 PMC 바로가기 [Article Type] Article
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가Research Article Published on 2022-01-132022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article
Risk perception and behaviour during the COVID-19 pandemic: Predicting variables of compliance with lockdown measuresResearch Article Published on 2022-01-052022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] Administered aversion avoidance behavioural character cognitive Compliance Control COVID-19 COVID-19 pandemic dimension driving Evidence Factor foundation Government Health help inherent Intention Intervention Italy joint lockdown locus measure Measures modulated modulating Moral National precautionary behaviours predict predicted promote Psychological questionnaire regressions risk temperament variable Variation [DOI] 10.1371/journal.pone.0262319 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 on pornography use: Evidence from big data analysesResearch Article Published on 2021-12-212022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] activity adopted affected Analysis anticipated association average changes in Coronavirus disease 2019 COVID-19 Daily database defined demonstrated examined Factor global pandemic Google home quarantine Impact impacted Increased insight Internet key factor lockdown measure Moderation modulated non-parametric test normality pandemic parameter parametric test Pornhub positively correlated public health Result retrospective RSV severity Shapiro-Wilk test significantly social distancing trend variable Volume website World Health Organization [DOI] 10.1371/journal.pone.0260386 PMC 바로가기 [Article Type] Research Article
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factorsCOVID-19는 분비된 대사 인자의 조절을 통해 새로운 발병 인슐린 저항성 및 지질 대사 조절 장애를 유발합니다Article Published on 2021-12-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Apelin Cohort complications COVID-19 COVID-19 patient Diseases dysregulation Endocrine system and metabolic diseases expression Glucose HDL-C hyperglycemia induce Infectious diseases insulin insulin resistance investigated isobutyric acid lipid metabolism lipids mechanism mechanisms metabolic factor metabolism modulated myeloperoxidase myostatin patients Perturbation Potential biomarker potential biomarkers potential therapeutic target potential therapeutic targets propionic acid Regulation reported REST resulting SARS-COV-2 infection secreted transcription factor transcriptional level [DOI] 10.1038/s41392-021-00822-x PMC 바로가기 [Article Type] Article
CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelinationResearch Article Published on 2021-12-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Activation Autoimmune CD4 CD40 CD40L Cell chronic infection CNS comparable Demyelination disease etiology Evidence exhibited expression hallmark Immunosuppression Immunosuppressive treatment indicate induce Infection infiltration Inflammatory Interaction investigated mechanism mice Migration modulated molecular mouse hepatitis mouse hepatitis virus Multiple Neuroinflammation Neurological disease pathogenic patients phagocytic poliomyelitis proceed Prophylaxis PROTECT Protective protective role recent recruitment reduced Result shown significantly susceptible T cell [DOI] 10.1371/journal.ppat.1010059 PMC 바로가기 [Article Type] Research Article
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 InfectionSARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘, [키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score [DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis
Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico AnalysisArticle Published on 2021-11-292022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] Altered coded coding gene COVID-19 COVID-19 patients CRISPR deregulated deregulation expression Factor functional Gene Expression IFN treatment interferon IRFs joint lncRNA Long long non-coding RNA majority manuscript mechanism modulate modulated MYC NFκB over pathogenesis of COVID-19 pathway Pathways PCG Protein Proteins Regulation resources RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-COV-2 infection significantly STATs target TFS tissue Transcription transcription factor transcription factors transcriptional regulation [DOI] 10.3390/ncrna7040074 PMC 바로가기 [Article Type] Article