Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Viral variants virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기
Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and miceArticle Published on 2022-08-302022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome animal model antibodies Antibody Response approved BALB/c mice breadth coronavirus COVID-19 CP: Immunology CP: Microbiology elicited Human humans immune evasion mice mouse Neutralizing antibody response Neutralizing antibody titer non-human primate non-human primates public health real time SARS-CoV-2 SARS-CoV-2 variant sensitivity understanding vaccine platform Vaccines VOCs [DOI] 10.1016/j.celrep.2022.111299 PMC 바로가기
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 항바이러스제의 효능을 평가하기 위한 SCID 마우스 모델Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 치료제, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral drugs antiviral efficacy antivirals B.1.351 B.1.351 variant BALB/c Beta Beta variant binding C57BL/6 CAGE coronavirus Culture drug hamsters Infection infectious virus titer infectious virus titers Infective dose inhibitors intrinsic lack log lung Lung pathology Lungs male mice Model moderate molnupiravir mouse mouse model Mouse models Nirmatrelvir offer Postinfection reagent receptor reduced replicate Replication reported SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain SARS-CoV2 SCID significantly TCID These data tissue tissue culture twice a day Validity variant variants variants of concern Viral load virus virus strain wild-type [DOI] 10.1128/jvi.00758-22 PMC 바로가기 [Article Type] Article
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article
The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2SARS-CoV-2로 인한 인플루엔자 폐렴 및 코로나바이러스 감염의 마우스 모델에서 선택된 항바이러스제와 아프로티닌 조합의 효능Article Published on 2022-08-052022-09-11 Journal: Molecules [Category] SARS, 치료제, [키워드] Antiviral antiviral drugs Aprotinin body weight Body weight loss clinical assessment Combination combinations coronavirus COVID-19 demonstrated drug Efficacy Infection Influenza influenza pneumonia Influenza virus lung Lungs mice Model mouse preclinical study reducing SARS-CoV-2 selected survival rate treatment of influenza virus virus titer weight loss [DOI] 10.3390/molecules27154975 PMC 바로가기 [Article Type] Article
Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model마우스 모델에서 BCG 백신 접종에 의한 COVID-19에 대한 교차 반응 항체 유도Article Published on 2022-07-302022-09-11 Journal: Current microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against antibodies antibody Antibody Response approach BCG BCG vaccination boost COVID-19 cross-reacting antibodies demonstrated explain help humoral immune response Immune escape immune responses Immunity induce induction investigated latent tuberculosis latent tuberculosis infection Model mouse mouse model non-specific potential tool potential tools rabies reducing reported SARS-CoV-2 SARS-CoV-2 spike spike tested the antibody response the SARS-CoV-2 Tuberculosis vaccination Vaccines variants [DOI] 10.1007/s00284-022-02971-w PMC 바로가기 [Article Type] Article
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice야생형 마우스에서 비활성화된 SARS-CoV-2의 생체분포 및 세포 내재화Article Published on 2022-07-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 receptors administration analyzed angiotensin attachment Brain can not caveolin cell entry receptor cell line cellular cellular uptake clathrin Consensus conserved expression heart help heparan sulfate heparan sulfate proteoglycans heparin human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo inactivated infected with SARS-CoV-2 Inflammation internalization intravenous Intravenous administration mammalian mice molecular interaction motif mouse Muridae murine organ Proteoglycan raised reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 receptors Spike protein sulfate syndecan syndecan-4 syndecans syndecans. tissue TNF-α transmembrane various tissues wild-type [DOI] 10.3390/ijms23147609 PMC 바로가기 [Article Type] Article
Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster modelMolnupiravir는 햄스터 모델에서 Omicron을 포함한 SARS-CoV-2 변이체를 억제합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Adults Alpha Analysis Antiviral approved Beta caused COVID-19 Delta VOC delta VoCs demonstrated drug drug therapy effective Efficacy examined hamster hamsters Histopathologic analysis identify infectious titer infectious titers inhibit inhibited inhibitory effect Lower respiratory tract lung Lung disease Lungs Measures mechanism molnupiravir mouse Mouse models mutagenic mutated nucleoside omicron Preexisting immunity reduction in Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the SARS-CoV-2 Treatment upper and lower respiratory tract variant Viral antigen viral RNA genome Virology virus replication VoC VOCs was reduced [DOI] 10.1172/jci.insight.160108 PMC 바로가기 [Article Type] Article
Diurnal Differences in Intracellular Replication Within Splenic Macrophages Correlates With the Outcome of Pneumococcal Infectionarticle Published on 2022-06-302024-09-01 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] circadian rhythm Image analysis immunohistochemistry Macrophage Microscopy mouse spleen Streptococcus pneumoniae [Article Type] article