Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association with Viral Load, Independent of Symptoms상부 호흡기에서 SARS-CoV-2에 대한 염증 반응의 종단 분석은 증상과 무관한 바이러스 부하와의 연관성을 보여줍니다Observational Study Published on 2021-09-282022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 임상, 진단, [키워드] Activation active site analyzed Anosmia antiviral response CCL2 collected conducted Control correlated COVID-19 cohort CXCL10 cytokine cytokine level cytokine levels cytokine response Cytokines different time point different time points dissemination elevated enrolled Geneva University Hospitals GM-CSF IgA IgG IL-6 immunological characteristics increase in Increases increases in independent of innate response intranasal load Local longitudinal Mild myeloid cells nasal Nasal cavity nasal epithelium Nasal wash observational study Patient produced recruitment remained respiratory response Result S1 domain Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum serum cytokine levels specimen Spike protein subset supplementary material Switzerland Symptom symptom onset Symptoms the spike protein therapeutic approaches tract understanding upper upper respiratory tract Viral load Virological virological and immunological characteristics virus [DOI] 10.1007/s10875-021-01134-z PMC 바로가기 [Article Type] Observational Study
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다Research Article Published on 2021-09-222022-09-10 Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons [DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis비정상적인 FLIP/STAT3 축에 의한 치명적인 사이토카인 방출 증후군Article Published on 2021-09-132022-09-10 Journal: Cell Death and Differentiation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] approach caspase caspase-8 characterized clinical phenotype Control COVID-19 CRS cytokine Cytokine release syndrome Cytokines death detect dysregulated elevated expressed expression homolog immune disorders immune response immune responses Inflammation Inflammatory inflammatory pathology Inflammatory responses inflammatory state Intervention life-threatening Lung injury Lungs lymphopenia mice multiple organ dysfunction myeloid cell myeloid cells organ dysfunctions Organ failure organ failures pandemic pathogen invasion pathophysiology pathway Pathways Protein provoke regulated response SARS-CoV-2 pandemic STAT3 suppress syndrome the SARS-CoV-2 triggered Viral [DOI] 10.1038/s41418-021-00866-0 PMC 바로가기 [Article Type] Article
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia식세포에서의 Krueppel-Like Factor 4 발현은 폐렴구균 폐렴에서 초기 염증 반응과 질병 중증도를 조절한다.Original Research Published on 2021-09-132024-07-30 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] community-acquired pneumonia Innate immunity Krueppel-like factor 4 myeloid cells Streptococcus pneumoniae [DOI] 10.3389/fimmu.2021.726135 PMC 바로가기 [Article Type] Original Research
Differential Effects of Prostaglandin D 2 Signaling on Macrophages and Microglia in Murine Coronavirus EncephalomyelitisResearch Article Published on 2021-09-072022-10-29 Journal: mBio [Category] Coronavirus, [키워드] absence activated Activation Central nervous system clearance CNS complex coronavirus disease Effect Encephalitis Encephalomyelitis expression identify immune response Infection infections infiltrating innate immune response Macrophage mice microglia mouse hepatitis virus (MHV) Ms4a3-cre murine myeloid cells neurotropic opposite PGD PGD2/DP1 axis phagocytosis prostaglandin receptor recruitment required resulting Signaling virus virus clearance [DOI] 10.1128/mBio.01969-21 PMC 바로가기 [Article Type] Research Article
Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia브루톤 타이로신 키나제 매개 신호전달은 폐렴구균 폐렴 동안 보호적인 선천 면역에 필요하다.Original Research Published on 2021-09-062024-07-30 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] BTK - Bruton’s tyrosine kinase mice myeloid cells natural antibodies Pneumonia Sepsis Streptococcus pneumoniae X-linked immunodeficiency [DOI] 10.3389/fimmu.2021.723967 PMC 바로가기 [Article Type] Original Research
S100A8 may govern hyper-inflammation in severe COVID-19S100A8은 심각한 COVID-19에서 과염증을 지배할 수 있습니다.Article Published on 2021-09-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 변종, 진단, 치료제, [키워드] accumulating Activation acute respiratory distress acute respiratory distress syndrome affected ARDS Biomarker calcium calcium-binding protein cells chronic myeloid leukemia clinical information Coagulation coagulation cascade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-associated ARDS disease disease severity effective Elimination endotoxin Evidence extrinsic form herd immunity homeostatic hyper-inflammation Hypothesis Immunity include increased vascular permeability Inflammation Interaction leukemia Ligand lung molecular target mortality rate myeloid cells myeloid-derived suppressor cells overcome pandemic Pathogens predict reagent receptor recruitment respiratory distress Respiratory distress syndrome S100A8 S100A9 severe COVID-19 severe forms of COVID-19 similarity situation syndrome TLR4 to define Toll-like receptor Treatment upregulated upregulation Vaccine vascular permeability [DOI] 10.1096/fj.202101013 PMC 바로가기 [Article Type] Article
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.423 Published on 2021-08-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvanticity alum alum adjuvant antibodies antibody Antibody Response Antibody responses Antigen Blood bloodstream blunt CD4 Cell-mediated immunity coronavirus COVID-19 patients Efficacy Elastase ENhance epitope Epitopes follicular help identify IgA antibodies IgA antibody IL-1 Immunity immunization Immunoglobulin IMPROVE induce inhibition inhibitor injected innate response interleukin investigated lack magnitude mice mucosal mucosal immunity mucosal route mucosal secretion mucosal tissue mucosal tissues myeloid cells neutrophil Neutrophil elastase neutrophil elastase inhibitor Neutrophils pharmacological promote protective antibodies Protective antibody Protein Protein subunit protein-based vaccine recruitment regulate response responses SARS-CoV-2 SARS-CoV-2 spike protein sera Serine serine protease serum antibody serum IgG severe acute respiratory syndrome Coronavirus SIgA Significance Spike protein stimulate subunit Support suppression T cell T cell responses T helper Tfh Th1 Th2 the spike protein vaccination Vaccine Vaccines [DOI] 10.1073/pnas.2102435118 PMC 바로가기 [Article Type] 423
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19증가 된 strem-1 혈장 농도는 Covid-19 환자의 임상 결과가 좋지 않은 것과 관련이 있습니다.Observational Study Published on 2021-07-302022-09-10 Journal: Bioscience Reports [Category] SARS, 바이오마커, 임상, [키워드] acute respiratory distress syndrome (ARDS) addition Analysis Care Cell circulating Clinical outcome clinical parameter Clinical parameters clinical trial Cohort cohorts of patient collected Concentration coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Course COVID-19 COVID-19 diagnosis COVID-19 patient death disease course disease severity electronic patient files elevated hazard ratio healthy control healthy controls higher risk ICU admission Increased independent indicated Infection Inflammation inflammatory reaction investigated involved Laboratory less modulation Mortality myeloid myeloid cells Non-survivors observational study outcome pathway Patient patients with COVID-19 plasma plasma concentration plasma concentrations receiving Result routine Sepsis severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe COVID-19 severely ill patient severely ill patients significantly soluble Triggering Receptor sTREM-1 survivor the disease therapeutic target validation cohort was performed were assessed with COVID-19 [DOI] 10.1042/BSR20210940 PMC 바로가기 [Article Type] Observational Study
C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of AgeC9orf72 중간 반복은 연령과 관계없이 심각한 COVID-19 폐렴에 대한 유전적 위험을 부여합니다Article Published on 2021-06-292022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age allele ALS Amyotrophic lateral sclerosis association Autoimmune Autoimmune disorders autophagy C9orf72 caused characterized Clinical outcome Cohort contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia Critical Cytokine storm Cytokines Degradation determinants driving dysfunction expressed feature frontotemporal dementia functions Gene Expression genetic background genetic cause genetic risk haploinsufficiency Host immune functions impair independent Infection innate immune response Innate immunity intermediate intermediate alleles involved Lateral Sclerosis lysosomal magnitude mechanical ventilation modulate Mutation myeloid cell myeloid cells Neuroinflammation Non-invasive non-invasive or mechanical ventilation Odds ratio pathogenic Patient phenotype Phenotypes proinflammatory cytokines Regulation Repeat responsible risk risk factor SARS-CoV-2 SARS-CoV-2 infected patients severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia significantly systemic level These data [DOI] 10.3390/ijms22136991 PMC 바로가기 [Article Type] Article