Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution바이러스 진화 중 SARS-CoV-2 수용체 결합 도메인의 돌연변이 제약 조건 이동Article Published on 2022-07-222022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alpha Amino acid angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Beta coronavirus Delta domain Effect epistasis Eta Evolution example facilitate Interpretation modulating Mutation N501Y occur omicron performed phenomenon RBD RBDs receptor Recognition respiratory SARS-CoV-2 SARS-CoV-2 evolution severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain subsequent Substitution substitutions the SARS-CoV-2 variant variants viral evolution Wuhan-Hu-1 [DOI] 10.1126/science.abo7896 PMC 바로가기 [Article Type] Article
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme고충실도 CRISPR-Cas12 효소를 사용한 COVID-19 변이체 탐지Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis Assay validation circulating variant clinical sample clinical samples Concordance COVID-19 COVID-19 patient COVID-19 patients CRISPR CRISPR-Cas12 detection DETECTR Diagnostic method enzyme Enzymes faster followed by Genome sequencing guide RNAs identify infection control isothermal amplification L452R Laboratory test Laboratory tests LAMP Loop-mediated isothermal amplification Mutation mutations N501Y nucleotide omicron Patient polymorphism public health real-time RT-PCR RNAs SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing single nucleotide Single nucleotide polymorphism SNP Surveillance target the SARS-CoV-2 Treatment treatment of COVID-19 patients utility variant variants Viral mutations viral mutations. whole-genome sequencing [DOI] 10.1128/jcm.00261-22 PMC 바로가기 [Article Type] Article
Novel Lateral Flow-Based Assay for Simple and Visual Detection of SARS-CoV-2 MutationsSARS-CoV-2 돌연변이의 간단하고 시각적인 검출을 위한 새로운 측면 흐름 기반 분석Article Published on 2022-07-142022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele amplification asymmetric comparable cycle threshold demonstrated detect detection DNA DNA microarray E484K feature identification impacted Increases K417N L452R Lateral lateral flow lateral flow strip lateral flow strip (LFS) limitations marker molecular molecular diagnostic multiplex Mutation mutations N501Y novel Public health responses real time recommendation reference method Region RNA extract RNA extracts RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 S gene SARS-CoV-2 variant SARS-CoV-2 variants simple spike mutation spike mutations Surveillance target variant variants of concern virus Visual Visual detection [DOI] 10.3389/fcimb.2022.902914 PMC 바로가기 [Article Type] Article
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화Article Published on 2022-07-072022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type [DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article
SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)Article Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant variants variants of concern variants of interest Variation viral infection virus VOCs VOIs [DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article
Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and IndiaB.1.1.7(알파) 및 B.1.617.2(델타)의 비교 유전체학, 진화 역학 및 RBD-hACE2 수용체 결합 패턴이 영국 및 인도의 대유행 반응과 관련됨Article Published on 2022-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis analyzed B.1.1.7 B.1.617.2 binding Cluster Comparative Comparative genomics COVID-19 infection Critical D614G Delta delta variant Epidemiology Evolutionary epidemiology Frequency genome sequence geographical distribution hACE2 help increase in India L452R MD simulation molecular Mutation mutations N501Y offer P681R pandemic performed phylogenetics plot Receptor binding reference strain Scatter plot scatter plots second second wave Spread stability submission Transmission variance Variance of UK and India. variant variants was performed Wuhan [DOI] 10.1016/j.meegid.2022.105282 PMC 바로가기 [Article Type] Article
Physicochemical effect of the N501Y, E484K/Q, K417N/T, L452R and T478K mutations on the SARS-CoV-2 spike protein RBD and its influence on agent fitness and on attributes developed by emerging variants of concernSARS-CoV-2 스파이크 단백질 RBD에 대한 N501Y, E484K/Q, K417N/T, L452R 및 T478K 돌연변이의 물리화학적 효과와 에이전트 적합성 및 우려되는 신흥 변이체에 의해 개발된 속성에 대한 영향Review Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition agent Alter attribute attributes binding caused changes in complex component convalescent sera Effect evade Evolution favor greater immune pressure immunodominant immunogenic induce inducer infection control infection process involved K417N L452R manuscript Mutation mutations N501Y occur Occurrence physicochemical Physicochemical effects Protective antibody RBD Receptor binding domain regions SARS-CoV-2 selective Spike protein spike protein RBD T478K target cells the RBD the SARS-CoV-2 the spike protein therapy Transmissibility turn Vaccine variant variant of concern variants of concern Viral transmission virulence virus virus expansion virus genome VoC VOCs [DOI] 10.1016/j.virol.2022.05.003 PMC 바로가기 [Article Type] Review
Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronavirusesSARS-CoV, SARS-CoV-2 및 관련 코로나바이러스의 RBD에 대한 말 ACE2의 결합 및 구조적 기초Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin angiotensin converting enzyme binding binding affinity causative agent continuous surveillance coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs crystal structure crystal structures enzyme equine events highlight host range humans infect Interaction Mutation N501Y omicron Prevent question RaTG13 RBD RBDs Receptor binding domain receptor binding domains residue SARS-CoV SARS-CoV-2 Surveillance target tested the binding affinity variant VOCs [DOI] 10.1038/s41467-022-31276-6 PMC 바로가기 [Article Type] Article
Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2글루코코르티코이드는 여러 부위에서 SARS-CoV-2 S1에 결합하여 ACE2와 SARS-CoV-2 S1 상호작용을 협력적으로 억제합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-SARS-CoV-2 Asymptomatic Beta bind binding binding energy binding pocket binding pockets biochemical biochemically catalytic activity causing cellular receptor chimeric conformational state contributed Cooperative coronavirus cortisol COVID COVID-19 patients Delta Dexamethasone disrupt E484K enzyme Glucocorticoids indicated inhibition Innate immunity Interaction K417N Limited mass spectrometry mechanism Mild molecular molecular dynamics monoclonal antibody Multiple mutant mutated N501Y omicron Omicron variants Protein Receptor binding domain reduce mortality SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike Site variant without affecting [DOI] 10.3389/fimmu.2022.906687 PMC 바로가기 [Article Type] Article