nasal mucosa – Page 4 – Communicable Diseases Research

Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection

Research Article

Published on 2021-05-242022-10-29
Journal: PLoS Pathogens [Category] COVID-19,

Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells

플루티카손 프로피오네이트는 1차 인간 비강 상피 세포에서 폴리(I:C) 유도 ACE2를 억제합니다

Cellular and Infection Microbiology

Published on 2021-04-262022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료기술,

[키워드] ACE2 ACE2 expression ACE2 protein Activation Affect affected agonist analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 cell entry collected Corticosteroid COVID-19 dissemination enzyme epithelial cells evaluate examined expression expression of gene fluticasone fluticasone propionate Fold change followed by Gene Expression Health health problem HNECs host cells Human immunoblot immunofluorescence incubated Incubation individuals Infection initial innate immune interferon intranasal intranasal steroid spray investigated mRNA expression nasal Nasal cavity nasal epithelial cell nasal mucosa NFκB objective poly(I:C poly(I:C) promote propionate protease Protein quantitative PCR receptor regulated required reservoir Result SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral SARS-CoV2 Serine serine 2 significantly increased Spread steroid suppresse suppressed thought TLR TLR agonists TLR3 TMPRSS2 Toll-like receptors transmembrane transmembrane protease serine 2 Viral virus infection
[DOI] 10.3389/fcimb.2021.655666 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Community Use of Face Masks against the Spread of COVID-19

Commentary

Published on 2021-03-192022-10-30
Journal: International Journal of Environmental Research an [Category] COVID-19, SARS,

[키워드] addition Asymptomatic benefit body temperature clearance Community condition conditions COVID-19 Critical Defense detrimental droplet early stage Evidence face Face mask Face masks favor health protection Human immune system infected individual inhibiting innate immune system Mask nasal Nasal cavity nasal mucosa physical barrier physiological physiological temperature pre-symptomatic Prevent PROTECT reduced SARS-CoV-2 Spread stability Support susceptibility temperature Transmissibility transmission of SARS-CoV-2 upper airway upper airways viral infection viral replication Viral transmission virion viruses warm
[DOI] 10.3390/ijerph18063214 PMC 바로가기 [Article Type] Commentary

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2

Bromelain과 Acetylcysteine(BromAc)의 조합은 SARS-CoV-2를 상승적으로 비활성화합니다

Article

Published on 2021-03-062022-09-10
Journal: Viruses [Category] SARS, 변종, 신약개발, 치료제,

[키워드] ACE2 receptor Acetylcysteine acute respiratory syndrome acute respiratory syndrome coronavirus administration binding breakage BromAc Bromelain clinical clinical testing coronavirus Culture demonstrated determine Disulfide disulfide bond Drug repurposing envelope protein envelope proteins glycoprotein Glycoproteins glycosidic host cell host cells in vitro inactivation Infection nasal nasal mucosa Patient recombinant reduce reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus spike spike glycoprotein spike mutants synergistic synergistic action therapeutic options Treatment virus virus culture wild-type worldwide pandemic
[DOI] 10.3390/v13030425 PMC 바로가기 [Article Type] Article

Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis

Research Article

Published on 2021-02-242022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

[키워드] ACE2 ACE2 expression ACE2 protein acute respiratory syndrome age airway alveolar epithelial cell angiotensin converting enzyme Autopsy Bacterial infection baseline bronchial epithelial cells bronchopulmonary dysplasia cellular ciliated ciliated epithelial cell Comparative analysis coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis current disease distribution Endothelial cell epithelial examined expression functional Human human respiratory tract human tissue immunoreactivity Lower respiratory tract lung lung homogenates Lung injury Lungs nasal mucosa Newborn NHP non-human primate paranasal sinus Pathogenesis patients with COVID-19 Pneumonia protease question raise receptor robust SARS-CoV-2 Serine significantly increased specimen specimens Support target TMPRSS2 transmembrane
[DOI] 10.1371/journal.pone.0247510 PMC 바로가기 [Article Type] Research Article

Cognitive impact of COVID-19: looking beyond the short term

Review

Published on 2020-12-302022-10-28
Journal: Alzheimer's Research & Therapy [Category] COVID-19, MERS, SARS,

[키워드] accelerate accumulating ACE inhibitor ACE-2 acute illness angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors angiotensin-converting enzyme-2 ApoE cardiorespiratory Central nervous system cerebral classical CNS Cognitive function Cognitive impairment COVID-19 COVID-19 patient current Dementia deplete develop disease Disseminated intravascular coagulation dysfunction Endothelial cell endothelial cells Evidence exacerbate exacerbating expression Follow-up hospitalised patient immune activation increased risk individuals infecting Inflammation inflammatory effect Lewy body Limited lowest medication Meta-analysis nasal mucosa Neurological complication neurons olfactory pathology Patient pericyte pericytes Phosphorylation predicted Protective RAS recent receptor reducing Respiratory disease Respiratory function risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virus Spread stroke suggested Survivors target therapy thrombosis vascular leakage vasculature virus White matter ischaemia
[DOI] 10.1186/s13195-020-00744-w PMC 바로가기 [Article Type] Review

Diagnostic testing for SARS-CoV-2 infection in HHT patients: nasopharyngeal versus oropharyngeal swab

HHT 환자에서 SARS-CoV-2 감염에 대한 진단 테스트: 비인두 대 구인두 면봉

Letter to the Editor

Published on 2020-12-182022-09-10
Journal: Orphanet Journal of Rare Diseases [Category] MERS, SARS, 진단, 치료기술,

[키워드] Affect Anemia arteriovenous malformations Asymptomatic autosomal dominant Blood blood transfusions Complication consequence coronavirus disease COVID-19 COVID-19 diagnosis defined detection rate determine Diagnosis diagnostic diagnostic sensitivity diagnostic test diagnostic testing disease Epistaxis evaluate followed by global pandemic greater Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia HHT highest Hospital admission hospitalizations Infection invasive knowledge leads Lower respiratory tract lower risk Molecular assay molecular assays molecular test nasal nasal mucosa nasal packing nasopharyngeal nasopharyngeal or oropharyngeal swab Nasopharyngeal swab nosebleed Nosebleeding Novel coronavirus novel coronavirus disease occur oropharyngeal swab outbreak pandemic Patient patients polymerase chain positive real-time reverse transcriptase reference standard repeated respiratory respiratory specimen respiratory specimens reverse transcriptase Reverse transcriptase polymerase chain reaction risk RT-PCR SARS CoV SARS CoV-2 SARS CoV-2 infection SARS-CoV-2 SARS-CoV-2 diagnosis SARS-COV-2 infection SARS-CoV-2 testing sensitivity Spread Swab symptomatic carriers telangiectasia the SARS-CoV-2 visceral WHO
[DOI] 10.1186/s13023-020-01628-w PMC 바로가기 [Article Type] Letter to the Editor

In search of preventive strategies: novel high-CBD C annabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues

예방 전략 찾기: 새로운 고 CBD C annabis sativa 추출물은 COVID-19 게이트웨이 조직에서 ACE2 발현을 조절합니다

Research Paper

Published on 2020-11-302022-08-31
Journal: Aging (Albany NY) [Category] SARS, 치료제,

[키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway Alter Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory properties cannabidiol cannabis caused CBD coronavirus COVID-19 COVID-19 pandemic Critical curtail decrease disease disease spread disease susceptibility down-regulate Effect effective expressed gastrointestinal tract Gene Expression Health Canada help host cells human host Inflammation intestinal tissues kidney lung tissue medical cannabis modulate modulation nasal mucosa prevention strategies Protein receptor reduce mortality regulate required Research respiratory Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV2 Serine serine protease serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus Spread susceptibility testes therapeutic therapy tissue tissues TMPRSS2 Viral viral entry while working
[DOI] 10.18632/aging.202225 PMC 바로가기 [Article Type] Research Paper

Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19

Angiotensin-Converting Enzyme-2 agonist를 함유한 비강 세척은 COVID-19의 바이러스 부하를 예방하고 감소시킬 수 있습니다

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] SARS, 치료제,

[키워드] ACE inhibitor ACE inhibitors angiotensin angiotensin converting enzyme angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme-2 Anosmia ARBs binding can be used Chain Reaction changes in conditions COVID-19 COVID-19 negative Critical Diagnosis Dilution dosage Efficacy enzyme evaluated False negative False negative rate Formulation heart rate high risk high risk patients hypothese hypotheses include infect cells low blood pressure management medicated medication mode mucosa nasal Nasal lavage nasal mucosa nasal symptom olfactory Olfactory pathway Patient patients PCR penetrate polymerase chain polymerase chain reaction positive patients Potential Prevent raise receptor Receptor Blockers receptors reduce report reported SARS-CoV-2 SARSCoV-2 secondary to Side effect suspicion Symptom trials Vaccine Viral Viral load water
[DOI] 10.1016/j.mehy.2020.110207 PMC 바로가기 [Article Type] Article

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract

Communication

Published on 2020-10-162022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,