Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort studyResearch Published on 2021-10-192022-10-29 Journal: Journal of Hematology & Oncology [Category] COVID-19, MERS, SARS, [키워드] 95% CI Analysis Anticoagulant association Atrial fibrillation clinical evidence conducted COVID-19 Cox regression death deaths direct oral anticoagulants DOAC DOACs Effect England Evidence hazard ratio Hospital admission HRs lower risk negative control NHS Non-COVID-19 OpenSAFELY oral anticoagulant outcome Patient platform population-based cohort positive primary care reported Result SARS-CoV-2 SARS-CoV-2 antigen severe COVID-19 severe COVID-19 disease supplementary material tested Thromboembolism Warfarin [DOI] 10.1186/s13045-021-01185-0 PMC 바로가기 [Article Type] Research
Assessing influenza vaccination success to inform COVID‐19 vaccination campaignResearch Article Published on 2021-10-112022-11-01 Journal: Journal of medical virology [Category] COVID-19, Fulltext, MERS, [키워드] 95% CI age Assessing association Asthma BMI body mass index COVID‐19 diabetes distribution effective Efficacy Factor help hepatitis B hepatitis B vaccine hypertension immunization strategy Influenza negative control positive predictor respiratory illnesses risk SARS‐COV2 severity significantly survey vaccination Vaccinations Vaccine variable [DOI] 10.1002/jmv.27368 PMC 바로가기 [Article Type] Research Article
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19Research Article Published on 2021-09-282022-10-29 Journal: PLoS Medicine [Category] COVID-19, SARS, [키워드] acute phase Adults affected affecting age analyzed atopic dermatitis calculated clinical feature co-occurrence co-occurrence network cognitive Cohort cohort of patient conducted COVID-19 COVID-19 diagnosis demographics described diagnosed diagnosed with COVID-19 diagnosis of COVID-19 effective EHR data Electronic health record estimate Evolution Factor feature Features female group had more had no hazard ratio headache healthcare help Illness severity incidence include Infection infection with SARS-CoV-2 Influenza inherent Kaplan–Meier analysis limitation long-COVID majority myalgia negative control occurred organ Pain Patient persistence profile receive receiving recorded reported Research researcher retrospective cohort study risk robust seeking severe COVID-19 illness Severity of infection Sex Significant significantly higher specificity subgroups survivor Survivors Symptom Symptoms the patient Treatment used data variety viral infection was used white [DOI] 10.1371/journal.pmed.1003773 PMC 바로가기 [Article Type] Research Article
Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health SystemResearch Published on 2021-09-172022-10-29 Journal: JAMA Network Open [Category] COVID-19, [키워드] Activation Administered age allergic reaction allergy anaphylaxis antibody assessment basophil Care Case series case sery classification component conducted COVID-19 COVID-19 vaccination criteria deaths detectable determine drug elevated exhibited explain exposure filtered finding Follow-up food glycol Health help Histamine IgE IgG immune response Immunoglobulin Immunological testing Importance individual individuals measure mechanism mechanisms mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine mRNA vaccines negative control objective participant Participants Patient Point positive reaction receiving Regional Relevance reported resolved responsible Result resulting revision risk risk factor setting skin SPT Suspected System tested Testing The United States the vaccine vaccinate Vaccine Vaccines were used women [DOI] 10.1001/jamanetworkopen.2021.25524 PMC 바로가기 [Article Type] Research
Development and Evaluation of Quantitative Immunoglobulin G Enzyme-Linked Immunosorbent Assay for the Diagnosis of Coronavirus Disease 2019 Using Truncated Recombinant Nucleocapsid Protein as Assay Antigen분석 항원으로 절단된 재조합 뉴클레오캡시드 단백질을 사용한 코로나바이러스 질병 2019 진단을 위한 정량적 면역글로불린 G 효소 연결 면역흡착 분석법의 개발 및 평가Article Published on 2021-09-132022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies Antigen applied can be used causative agent collected complementary conserved conserved region coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis cross-reactive cross-reactive antibodies cross-reactive antibody deleted demonstrated development Diagnosis E. coli ELISA evaluate full-length gold IgG IgG ELISA IgG indirect ELISA Immunoglobulin Immunoglobulin G less N protein negative control neutralization test nucleocapsid protein plaque reduction neutralization Plaque reduction neutralization test prevalent PRNT Protein protein expression real-time RT-PCR recombinant respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 spike protein sensitivity sera Serological assay serological assays severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity spike IgG Spike protein Surveillance [DOI] 10.3390/ijerph18189630 PMC 바로가기 [Article Type] Article
Adverse drug event risk assessment by the virtual addition of COVID-19 repurposed drugs to Medicare and commercially insured patients’ drug regimens: A drug safety simulation studyCOVID-19 용도 변경 약물을 Medicare 및 상업적으로 보험에 가입된 환자의 약물 요법에 가상으로 추가하여 약물 부작용 위험 평가: 약물 안전성 시뮬레이션 연구Observational Study Published on 2021-09-012022-09-11 Journal: Clinical and translational science [Category] MERS, 신약개발, 임상, 치료제, [키워드] added addition ADE ADEs Adverse age Analysis approved Azithromycin baseline blueprint calculate caused Chloroquine clinical trials conducted coronavirus disease Coronavirus disease 2019 COVID-19 driven by drug drug interaction drug regimen drug regimens drugs event fexofenadine greater groups Health Health Insurance Hydroxychloroquine increase in increased risk indications Intervention Long Long QT syndrome Lopinavir Lopinavir/ritonavir median Medicare medication medication risk negative control Patient performed positive Repurposed drug Repurposed drugs risk Ritonavir subject terfenadine Treatment were used [DOI] 10.1111/cts.13025 PMC 바로가기 [Article Type] Observational Study
Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명Research Published on 2021-08-142022-09-10 Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus [DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research
Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort studyClinical Science Published on 2021-07-252022-10-28 Journal: Rheumatology (Oxford, England) [Category] COVID-19, [키워드] 1.26 95% CI age Analysis calibrated cohort study Community concern coronavirus disease country Cox model Depression dose electronic medical record epidemiology, RA estimate event events Germany hazard ratio HCQ Hospitalization HRs hydroxychloroquine treatment ideation indication negative control no effect objective outcome pandemic PAS Patient performed Propensity score Psychiatric Psychosis raised Regulatory Result rheumatology risk Safety Stratification Study protocol treat Treatment USA were used [DOI] 10.1093/rheumatology/keaa771 PMC 바로가기 [Article Type] Clinical Science
SARS-CoV-2: preliminary study of infected human nasopharyngeal tissue by high resolution microscopyShort Report Published on 2021-07-182022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] AFM Algorithm Anosmia Antigen apical cell Asymptomatic atomic cell cultures cell membrane characteristic collected confocal microscopy coronavirus COVID-19 etiological agent expected explain healthy High-resolution improvement in some individuals mathematical Microscopy microvilli morphology Nasal Epithelial cells nasopharyngeal nasopharyngeal sample negative control Novel coronavirus novel coronavirus SARS-CoV-2 Particle patients performed positive positive sample processed regions reported Result RT-PCR Sample SARS CoV-2 SARS-CoV SARS-CoV-2 SEM specimen structures supplementary material Swab symptomatic tissue Transmission treated virion virus zone [DOI] 10.1186/s12985-021-01620-1 PMC 바로가기 [Article Type] Short Report
SARS-CoV-2 inactivated vaccine (Vero cells) shows good safety in repeated administration toxicity test of Sprague Dawley ratsSARS-CoV-2 불활화백신(Vero cells), Sprague Dawley 쥐 반복투여 독성시험에서 우수한 안전성 입증Article Published on 2021-06-012022-09-11 Journal: Food and chemical toxicology : an international jo [Category] 비임상, [키워드] administration breath change clinical trial clinical trials COVID-19 dose effective evaluate experimental group Formulation global public health Good High-dose inactivated Inactivated vaccine injected Intramuscular injection Local negative control Neutralizing antibodies neutralizing antibody observé outbreak Practice premise Prevent repeated Research Safe Safety SARS-CoV-2 SARS-CoV-2 vaccine severity Spread stimulate The inactivated vaccine The repeated administration toxicity. the vaccine tissues Toxic reaction Toxicity toxicity test Vaccine vaccine group Vero cells virus [DOI] 10.1016/j.fct.2021.112239 PMC 바로가기 [Article Type] Article