Effect of a genetically engineered interferon-alpha versus traditional interferon-alpha in the treatment of moderate-to-severe COVID-19: a randomised clinical trial중등도에서 중증의 COVID-19 치료에서 유전적으로 조작된 인터페론-알파 대 전통적인 인터페론-알파의 효과: 무작위 임상 시험Randomized Controlled Trial Published on 2021-02-232022-08-09 Journal: Annals of Medicine [Category] 임상, 치료제, [키워드] 1:1 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus adaptive immune responses added Adverse adverse events Alpha antiviral agent Antiviral agents antiviral therapy ARMS assigned baseline antiviral agent baseline antiviral agents Clinical efficacy Clinical improvement clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Effect effective therapy Effectiveness Endpoint event groups head immune responses interferon Interferon alpha interferon-alpha interferon-alpha group interferon-alpha nebulization Lopinavir Lopinavir–ritonavir lopinavir–ritonavir or umifenovir Middle East Middle East respiratory syndrome Coronavirus moderate-to-severe COVID-19 multicenter Negative conversion nucleic acid outbreak pandemic participant Patient patients hospitalized primary endpoint radiological improvement randomised Randomized recombinant super-compound interferon respiratory respiratory syndrome coronavirus Result Ritonavir rSIFN-co rSIFN-co group rSIFN-co nebulization rSIFN-co therapy SARS CoV-2 secondary Secondary endpoints severe acute respiratory syndrome Coronavirus shown traditional interferon-alpha Treatment Trial umifenovir virus nucleic acid [DOI] 10.1080/07853890.2021.1890329 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical characteristics of hospitalized mild/moderate COVID-19 patients with a prolonged negative conversion time of SARS-CoV-2 nucleic acid detectionSARS-CoV-2 핵산 검출의 음성 전환 시간이 연장된 입원 경증/중증도 COVID-19 환자의 임상 특성Research Article Published on 2021-02-032022-09-10 Journal: BMC Infectious Diseases [Category] MERS, 치료기술, [키워드] 95% CI 95%CI Abnormalities abnormality Analysis analyzed Characteristics Chest CT clinical Clinical characteristics Clinical features clinical manifestation clinical symptom cough COVID-19 COVID-19 patient COVID-19 patients diarrhea Disease progression enrolled erythrocyte expectoration Factor Factors Fever hemoglobin Hospitalized independent laboratory data leucocyte median Multivariate analysis nausea Negative conversion Negative conversion time Patient predict provided Result risk factor Risk factors SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 RNA supplementary material the patient Treatment treatment of COVID-19 Treatment outcome Univariate analysis Viral Viral RNA were used [DOI] 10.1186/s12879-021-05851-z PMC 바로가기 [Article Type] Research Article
The role of peripheral blood eosinophil counts in COVID-19 patientsCOVID-19 환자에서 말초 혈액 호산구의 역할Article Published on 2021-02-012022-08-31 Journal: Allergy [Category] MERS, SARS, 바이오마커, [키워드] Admission Blood body temperature center Chest CT China circulating clinical clinics collected coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19 patients decrease Diagnosis disease effective Efficiency EOS eosinophil fatigue Fever General Hospital gradually increased Hospital stay hospitalized COVID-19 patient IMPROVE involved Laboratory lesion lymphocyte majority marker Negative conversion neutrophil Neutrophil-to-lymphocyte ratio nucleic acid Patient patients peripheral Peripheral blood peripheral blood eosinophils Pneumonia Prognosis Public Radiographic radiologic Research retrospective severity Shanghai Shanghai Public Health Clinical Center Shortness of breath significantly more Spread synchronous virus infection Wuhan [DOI] 10.1111/all.14465 PMC 바로가기 [Article Type] Article
Atypical presentations of coronavirus disease 2019 (COVID-19) from onset to readmission발병부터 재입원까지 코로나바이러스 질병 2019(COVID-19)의 비정형적 프레젠테이션Multicenter Study Published on 2021-01-292022-09-01 Journal: BMC Infectious Diseases [Category] MERS, 진단, 치료기술, [키워드] affected Asymptomatic asymptomatic infection asymptomatic infections asymptomatic patient asymptomatic patients Atypical categories category chi-square test clinical feature Clinical features Cohort complementary coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cohort COVID-19 patient CT imaging negative disease stages effective Features FIVE GGOs Ground-glass opacities ground-glass opacity group had more help Hospitalization independent information investigated Kruskal-Wallis H test lung lung involvement lymphocyte Lymphocyte count management Moderate COVID-19 Negative conversion Patient patients patients with moderate performed positive Re-detectable positive readmission recruited Result RNA Significant Student’s t test supplementary material Symptomatic patients total score [DOI] 10.1186/s12879-020-05751-8 PMC 바로가기 [Article Type] Multicenter Study
Clinical implication and risk factor of pneumonia development in mild coronavirus disease 2019 patientsObservational Study Published on 2021-01-012022-10-05 Journal: The Korean journal of internal medicine [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval age analyses Analysis characterized Chest radiograph clinical Clinical course conducted coronavirus disease cough COVID-19 diarrhea Dyspnea elderly evaluated Factor hazard ratio Hospital admission hospitalized patients increased risk Kaplan-Meier log-rank test majority median Mild mild COVID-19 patient mild COVID-19 patients Mortality multivariate Cox regression Negative conversion Odds ratio onset of symptom Patient Pneumonia retrospective cohort study risk factor Risk factors significant variables significantly single center viral clearance viruses [DOI] 10.3904/kjim.2020.329 PMC 바로가기 [Article Type] Observational Study
Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: A retrospective cohort studyTanreqing Capsule이 COVID-19 환자에서 핵산의 음성 전환 시간에 미치는 영향: 후향적 코호트 연구Article Published on 2021-01-012022-08-31 Journal: Journal of integrative medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] addition Administered Capsule CD3 CD4 CD45 center Chinese clinical Clinical efficacy complement conducted control group control groups coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnostic testing COVID-19 patient COVID-19 patients diagnostic diagnostic testing disease Effect fecal hospital immune laboratory-confirmed mechanism Mild moderate Moderate COVID-19 negative Negative conversion Negative conversion rate nucleic acid pandemic Patient pharyngeal Pharyngeal swab Public reductions in retrospective cohort study Shanghai Shanghai Public Health Clinical Center Significant significant reductions statistically significant difference subset T cell T cells T-cell Tanreqing Capsule. the median Therapeutic benefit Traditional Traditional Chinese medicine treated Treatment treatment group was used [DOI] 10.1016/j.joim.2020.10.002 PMC 바로가기 [Article Type] Article
Diverse clinical processes of 16 COVID-19 cases who concentrated infection in the same workplace in Beijing, China An observational studyObservational Study Published on 2020-12-242022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] Beijing change China clinical manifestation clinical manifestations concentrated infection COVID-19 COVID-19 case diagnosed diverse clinical processes female Infection Lung injury medication Mild Negative conversion outbreak Patient patients patients of COVID-19 positive positive patient prevention respiratory tract RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 virus significantly source of infection sputum Sputum sample Stool Symptoms the median understanding were infected were recorded [DOI] 10.1097/MD.0000000000023800 PMC 바로가기 [Article Type] Observational Study
Risk factors for delayed negative conversion of SARS-CoV-2 in patients with COVID-19 pneumonia: a retrospective cohort studyOriginal Paper Published on 2020-12-012022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] Admission albumin Analysis Aspartate aminotransferase AUC CD3 CD4 Chest China Comorbidities consecutive patient coronavirus disease correlated cough COVID-19 COVID-19 patient COVID-19 patients Epidemic erythrocyte sedimentation rate ESR Factor group identify incidence interquartile leucocytes lymphocyte Lymphocytes mechanical ventilation median Negative conversion neutrophil Neutrophils Older age Patient patients with COVID-19 positively correlated quarantine receive retrospective retrospective cohort study risk factor Risk factors ROC Curve SARS-CoV-2 Spread symptom onset the median the patient two group university virus Wuhan [DOI] 10.1017/S0950268820002940 PMC 바로가기 [Article Type] Original Paper
Is there any potential management against COVID-19? A systematic review and meta-analysisCOVID-19에 대한 잠재적인 관리가 있습니까? 체계적인 검토 및 메타 분석Meta-Analysis Published on 2020-12-012022-09-11 Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] 치료제, [키워드] 95% CI 95% confidence interval Anakinra antiviral therapy article articles calculate Clinical effect Clinical improvement Clinical management convalescent plasma Convalescent plasma therapy COVID-19 COVID-19 infection COVID-19 pandemic Critical database declined Effect Efficacy eligibility criteria estimation Frequency had no Hydroxychloroquine ICU identify immunomodulator immunomodulators Immunomodulatory agent Immunomodulatory agents Improvements inception infected patients intensive care intensive care unit Intervention management mechanical ventilation medication medications Meta-analysis Mortality mortality rate Negative conversion no effect outcome outcomes Patient plasma plasma therapy Quantitative analysis random-effects model reduce Relative risk risk SARS-CoV-2 Scholar searched shown significantly standard treatment suggested systematic review therapy Tocilizumab Treatment was performed [DOI] 10.1007/s40199-020-00367-4 PMC 바로가기 [Article Type] Meta-Analysis
Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): study protocol for a randomized controlled trialCOVID-19 환자의 인터페론 β-1a(IFNβ-1a)(INTERCOP): 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2020-11-232022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 7-point ordinal scale addition Administered ameliorated animal model animal models anti-viral activity anti-viral drug antibody biochemical marker biochemical markers blood cell blood cell counts changes in clinical benefit clinical benefits clinical severity score clinical status clinical trial Combination Computed tomography cornerstone coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 treatment cytokine death dose Efficacy EudraCT Evidence evidence of Hospital stay Identifier IFNβ-1a IFNβ IFNβ-1a implication in vitro include indicated Inflammatory intensive care intensive care unit INTERCOP INTERCOP trial interferon interferon-stimulated genes International international units intervention arms mild-to-moderate disease moderate disease Mortality mRNA expression profile nasopharyngeal swabs Negative conversion Open-label Ordinal Scale organ dysfunction outcome oxygen oxygen- Patient Pneumonia positive swab Potential Primary outcome pulmonary computed tomography pulmonary computed tomography severity score radiological Randomized Randomized controlled trial rationale reduce reduced reduction regimens Safe SARS-CoV-2 SARS-COV-2 infection secondary Secondary outcomes Serious Adverse Events severity Standard of care Study protocol subcutaneously therapeutic therapy transfer Treatment Trial Trial registration Ventilator-free days Viral Viral load worsening [DOI] 10.1186/s13063-020-04864-4 PMC 바로가기 [Article Type] Study Protocol