Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes중증 급성 호흡기 증후군 코로나바이러스 2 바이러스혈증은 코로나바이러스 질병 2019 심각도와 연관되어 있으며 임상 결과를 예측합니다Observational Study Published on 2022-05-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 19 outcome 2 RNAemia 2 viremia acute respiratory syndrome acute respiratory syndrome coronavirus Admission Antibody titers bloodstream Care clinical clinical outcomes Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patient COVID-19 severity cross-sectional discharge disease severity electron tomography hazard ratio Health Organization Hospitalized Host immune response host immune responses ICU ICU Patients immune responses immunostaining indicate Inflammatory biomarker Inpatients Level Mortality Neutralizing antibody titer neutralizing antibody titers non-ICU outcome outcomes Outpatient outpatients Patient pellet plasma plasma sample plasma samples quantified reflect respiratory SARS SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Viral Viral RNA Viremia virion virions virus particle virus particles Visualization vRNA WHO World Health Organization [DOI] 10.1093/cid/ciab686 PMC 바로가기 [Article Type] Observational Study
Fitness of B-Cell Responses to SARS-CoV-2 WT and Variants Up to One Year After Mild COVID-19 – A Comprehensive Analysis경증 COVID-19 이후 최대 1년까지 SARS-CoV-2 WT 및 변이체에 대한 B 세포 반응의 적합성 - 종합 분석Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation All participants Alpha Anti-RBD antibodies antibodies antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigen-specific memory B cells assays avidity B-cell binding binding antibodies binding antibody Comprehensive correlated COVID-19 declined Delta delta variant domain ELISA ELISPOT evaluate fitness Gamma IgA IgG memory B memory B cell memory B cells memory B-cell Mild N protein neutralization Neutralizing Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers nucleocapsid participant plasmablast plasmablast responses plasmablasts post infection predicted Protein remained response SARS-CoV-2 SARS-CoV-2 specific memory B cells SARS-CoV-2 WT significantly increased symptomatic thiocyanate titers variant variants variants of concern waned were assessed were measured wild-type Year [DOI] 10.3389/fimmu.2022.841009 PMC 바로가기 [Article Type] Article
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients면역 저하 환자의 COVID-19 mRNA 백신에 의한 우려 변종에 대한 체액 반응Article Published on 2022-05-012022-09-11 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019-nCoV Against age All participant All participants Alpha anti-spike antibody Antibody titer Antibody titers association Autoimmune disease Autoimmune diseases best Beta Beta variant binding BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Cancer cancers circulating concern conducted COVID-19 decrease Delta delta variant Delta variants dose Effectiveness elicited enrolled female Gamma greater healthy control healthy controls hematologic Humoral response humoral responses IgG Immunocompromised patient Immunocompromised patients median Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 NAb NAb responses NAbs nCoV neutralizing antibody neutralizing antibody titers outcome participant Participants Patient patient population performed persistence Pfizer-BioNTech Primary outcome proportion proportions response response to vaccination responses against SARS-CoV-2 SARS-CoV-2 variants secondary outcome solid cancers solid organ solid organ transplant solid organ transplants study group the healthy the patient the SARS-CoV-2 Treatment underlying disease university vaccination vaccination schedule Vaccine Vaccines variant variants variants of concern VoC VOCs were measured [DOI] 10.1001/jamaoncol.2022.0446 PMC 바로가기 [Article Type] Article
Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples혈액 샘플에서 중화 SARS-CoV-2-S1 항체를 검출하기 위한 완전 자동화 분석의 기초로서 SARS-CoV-2-S1 ACE-2 수용체 상호작용의 적용Article Published on 2022-05-012022-09-11 Journal: Journal of Immunological Methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE-2 receptor ACE-2 receptor binding inhibition assay anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers application automated binding blood sample Blood samples BNT162b2 Concentration Control convalescent patient Convalescent patients detect determine Diagnostic method EliA high correlation Interaction large cohort mRNA mRNA-1273 neutralization test Neutralizing Neutralizing antibodies neutralizing antibody neutralizing antibody titers Phadia plaque reduction neutralization PRNT provide quantified Quantitative SARS-CoV-2 SARS-CoV-2 S1 protein Sensitivity and specificity [DOI] 10.1016/j.jim.2022.113258 PMC 바로가기 [Article Type] Article
Are SARS-CoV-2 Antibodies Detectable in Human Milk After Vaccination Against COVID-19?COVID-19 백신 접종 후 SARS-CoV-2 항체가 모유에서 검출될 수 있습니까?Article Published on 2022-04-302022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Against analyzed anti-SARS-CoV-2 antibody Antibody titers Antibody Units association authors benefit binding antibody unit binding antibody units BNT162b2 BNT162b2 mRNA Breastfeeding children Clinical outcome Concentration conducted control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine domain dose Effectiveness evaluated Factors gold gold standard HCW HCWs healthcare worker Human human milk IgA IgG IgG level IgG levels IgM immune response immune responses Immunity immunization Immunoglobulin immunoglobulin A Immunoglobulin G immunoglobulin M in vitro include independent ineligible Infant Infants Infection Influenza lack lactation limitation linear milk mother mRNA mRNA COVID-19 vaccines mRNA-1273 Multiple regression neutralization tests Neutralizing antibody titer neutralizing antibody titers nucleocapsid protein nutrition pandemic participant Participants plaque reduction neutralization positive correlation predicted Prospective Study Protein receipt receiving recipient reported Research respiratory S1 IgG SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serology serum subgroup analysis Support transfer vaccination Vaccines was performed women [DOI] 10.1093/jpids/piac024 PMC 바로가기 [Article Type] Article
Vaccine protection against the SARS-CoV-2 Omicron variant in macaques원숭이의 SARS-CoV-2 오미크론 변종에 대한 백신 보호Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus antibody Antibody titer Antibody titers B.1.1.529 BNT162b2 BNT162b2 vaccine Bronchoalveolar lavage CD8+ T cell Cellular immune response contribute correlated cynomolgus macaques demonstrated Efficacy heterologous prime-boost High-dose homologous humoral immune responses macaque macaque. moderate mRNA mRNA-based mutated nasal swabs neutralizing antibody titers omicron populations question raised regimen respiratory response robust SARS-CoV-2 SARS-CoV-2 variant Spread T cell T cell responses the SARS-CoV-2 These data undetectable upper respiratory tract Vaccine Vaccines variant virus [DOI] 10.1016/j.cell.2022.03.024 PMC 바로가기 [Article Type] Article
Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice변이체 일치 또는 과거 mRNA 백신으로 부스팅하면 마우스에서 오미크론 감염으로부터 보호Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody titers booster Breakthrough infection cytokine Cytokines dose Efficacy ENhance evaluated Immunity Infection Inflammation inflammation in the lungs inhibited less Lineage lung Lungs mice Moderna mRNA-1273 vaccine mRNA mRNA vaccine mRNA-1273 mRNA-1273 vaccine neutralization neutralized Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers omicron Pathogenesis PROTECT Protective SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants Strains Substitution vaccination Vaccine variant Viral viral burden WA1/2020 [DOI] 10.1016/j.cell.2022.03.037 PMC 바로가기 [Article Type] Article
Considerations for the Feasibility of Neutralizing Antibodies as a Surrogate Endpoint for COVID-19 VaccinesCOVID-19 백신의 대리 종점으로서 중화 항체의 가능성에 대한 고려 사항Review Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] Administered analyzed Antibody titers approach approved clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines develop dose Effectiveness Efficacy Efficiency elicited Emergency use Endpoint endpoints Enrollment feasibility immune response immune responses National national standard neutralization neutralization test Neutralizing neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing antibody titers open overcome pandemic platform Prevent Research research and development Selection standard neutralization test assay surrogate surrogate endpoints. Transmissibility vaccination Vaccine Vaccines variant variants widespread [DOI] 10.3389/fimmu.2022.814365 PMC 바로가기 [Article Type] Review
Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variantSARS-CoV-2 델타 변이체에 의한 돌발성 감염 후 백신을 완전히 접종한 개인의 면역 반응 특성화Article Published on 2022-04-202022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anamnestic antibody Antibody Response Antibody titers binding antibody Breakthrough infection breakthrough infections CD8 characterization Cluster Combination coronavirus demonstrated immune response individual Infection Massachusett Massachusetts mucosal nasal Neutralizing antibody titer neutralizing antibody titers Peripheral blood population immunity positive reported respiratory robust SARS-CoV-2 secretion serum antibody serum antibody response severe acute respiratory syndrome Coronavirus Spike protein T cell T cell response T cell responses tested the SARS-CoV-2 These data vaccinated individual vaccinated individuals vaccination variant variants waning immunity widespread [DOI] 10.1126/scitranslmed.abn6150 PMC 바로가기 [Article Type] Article
Sequential immunizations confer cross-protection against variants of SARS-CoV-2, including Omicron in Rhesus macaques순차 예방접종은 붉은털원숭이의 오미크론을 포함한 SARS-CoV-2 변종에 대한 교차 보호를 제공합니다.Article Published on 2022-04-182022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Administered animal animals Antibody titers Beta booster dose booster vaccination CoronaVac cross-protection Delta determine dose effective Effectiveness histopathological Homologous vaccine immunization immunized Inactivated vaccine Inactivated Vaccines indicated majority mutations NAbs Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers omicron Omicron variants primates profile PROTECT reduced viral load rhesus macaque rhesus macaques SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody significantly Subunit vaccine these viruses Vaccine variant variants variants of SARS-CoV-2 Viral virus viruses VOCs wild-type [DOI] 10.1038/s41392-022-00979-z PMC 바로가기 [Article Type] Article