Neutralization of SARS-CoV-2 Variants by mRNA and Adenoviral Vector Vaccine-Elicited AntibodiesmRNA 및 아데노바이러스 벡터 백신 유도 항체에 의한 SARS-CoV-2 변이체의 중화Article Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenoviral vector-based vaccine adenoviral vector-based vaccines antibody Antibody titers benefit Beta BNT162b2 Breakthrough infection breakthrough infections COV2.S decrease Delta Delta plus Effectiveness elicited fraction immunization Lambda less mRNA mRNA-1273 mRNA-1273. mRNA-based neutralization Neutralizing antibody titer neutralizing antibody titers Neutralizing titer Prevalence pseudotyped virus raised SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 Surveillance vaccinated individual vaccinated individuals Vaccine variant variants vector viruses were measured [DOI] 10.3389/fimmu.2022.797589 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not enhance viral infectionCOVID-19 회복기 혈장의 항-SARS-CoV-2 IgG 및 IgA 항체는 바이러스 감염을 강화하지 않습니다Research Article Published on 2022-03-082022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] absence ACE2 addressed ADE Alpha analyzed anti-S IgG antibodies antibody Antibody-dependent enhancement approach cause CCP clinical outcomes convalescent plasma correlated COVID-19 death elicit ENhance expressing Fc receptor Fc receptors IgA IgA antibody IgG IgM response IgM responses immunization Infection isotype monoclonal antibody neutralization activity Neutralizing activity Neutralizing titer not affected Novel coronavirus observation pandemic passive immunization passive transfer Prophylactic protective immune response question receptor SARS-CoV-2 Spike protein Support target cell target cells the spike protein theoretical risk therapeutic use therapy transfer transfusion Treatment vaccination Vaccine vaccine platform viral infection Virus neutralization virus receptor while [DOI] 10.1371/journal.pone.0257930 PMC 바로가기 [Article Type] Research Article
Neutralizing Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Induced by Natural Infection or Vaccination: A Systematic Review and Pooled Analysis중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 변이체에 대한 중화 항체 자연 감염 또는 예방 접종으로 유도: 체계적인 검토 및 통합 분석Article Published on 2022-03-012022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 변종, 진단, [키워드] (alpha (Beta) 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha antibody Antibody titers average B.1.1.7 B.1.351 B.1.617.2 collected coronavirus coronavirus 2 eligibility criteria escaped evaluated fold Immunity induced infected individuals Infection Lineage Live virus Messenger RNA natural natural infection neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers P.1 platform Protein subunit reduction in reductions in respiratory review SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants searched serum severe acute respiratory syndrome Coronavirus significant reductions significantly titers vaccination vaccination. Vaccine vaccinee vaccinees variant variants [DOI] 10.1093/cid/ciab646 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study3차 접종 동종 BBIBP-CorV 부스팅 백신의 안전성 및 면역원성: 전향적 공개 연구의 중간 결과Original Article Published on 2022-02-232022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Administered Adults adverse event anti-RBD antibody baseline baseline level baseline levels BBIBP-CorV booster booster vaccination booster vaccination shot cell-mediated immune circulating concern conducted control group COVID-19 dose evaluated examined female GMT healthy homologous humoral IFN-γ IgG Immunity immunogenic immunogenicity Neutralizing titer neutralizing titers Open-label participant PBMC PBMCs peptide prototype reduced reported Safe Safety SARS-CoV-2 SARS-CoV-2 inactivated vaccines SFU significant increase significantly higher significantly increased sVNT vaccination variants VoC VOCs [DOI] 10.1080/22221751.2022.2025746 PMC 바로가기 [Article Type] Original Article
Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model비인간 영장류 면역원성 모델에서 3차 부스트 백신 접종 후 Pan-SARS 중화 반응Article Published on 2022-02-232022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] (Beta adjuvant Administered antibody Beta boost booster breadth Combination COVID-19 cynomolgus macaques Delta E484K mutation evaluated Gamma Heterologous identify increase in independent independent of induce Infection modality mRNA vaccine mRNA vaccine. mRNA vaccines naïve neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing response Neutralizing titer neutralizing titers NHP NHPs non-human primate pre-immune produced Protein raised RBD Receptor binding domain reduced regimen robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants sequence spike Spike protein subunit Support tested vaccination Vaccine variants variants of concern virus Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.01.021 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Virus-Like Particle Neutralizing Capacity in Blood Donors Depends on Serological Profile and Donor-Declared SARS-CoV-2 Vaccination History혈액 기증자의 SARS-CoV-2 바이러스 유사 입자 중화 능력은 혈청학적 프로필과 기증자가 선언한 SARS-CoV-2 예방 접종 이력에 따라 다릅니다.Research Article Published on 2022-02-162022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed anti-RBD anti-receptor-binding domain anti-S Anti-spike antibody approach B.1.1.7 B.1.351 B.1.617.2 Beta Blood blood donor Blood donors breadth Canadian Capacity characterized coronavirus cross-sectional cross-sectional design Delta Donor elevated Evidence evidence of Gamma groups history humoral indicate initial initial stages less neutralization neutralization assays neutralization capacity Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers nucleocapsid Particle plasma presence or absence profile Protein Pseudotyped virus random Receptor-binding domain reduced repeated respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant second dose second dose of vaccine service severe acute respiratory syndrome Coronavirus signal significantly specimen spike Stage stratified subset unlikely vaccination Vaccine variant variants of concern virus-like particles VLP VLPs VoC VOCs was used wild type wild-type [DOI] 10.1128/spectrum.02262-21 PMC 바로가기 [Article Type] Research Article
Systemic and Lower Respiratory Tract Immunity to SARS-CoV-2 Omicron and Variants in Pediatric Severe COVID-19 and Mis-CArticle Published on 2022-02-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute COVID-19 Antibody Response Beta children circulating coronavirus disease COVID-19 evaluated Gamma Immunity implication Inflammatory information Iota Lower Lower respiratory tract MIS-C mucosal mucosal immunity neutralization neutralizing antibody Neutralizing antibody response Neutralizing titer omicron Patient patients pediatric plasma Re-infection respiratory SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 WA1/2020 severe COVID-19 syndrome systemic systemic immune response the SARS-CoV-2 Trachea tract variants variants of concern variants of interest viral respiratory infection VoC VOCs VOIs WA1/2020 while [DOI] 10.3390/vaccines10020270 PMC 바로가기 [Article Type] Article
A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis유지 혈액투석을 받는 환자에서 mRNA 백신 3차 접종의 정당성, 안전성 및 효능에 대한 전향적 관찰 연구Observational Study Published on 2022-02-012022-09-12 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Administered administration Analysis Anti-RBD IgG Anti-spike BNT162b2 CD4 Cohort COVID-19 COVID-19 incidence COVID-19 mRNA vaccine diagnosed died dose doses Efficacy enrolled French generate had more Hemodialysis high responder humoral IgG IMPROVE incidence interferon gamma mRNA vaccine mRNA vaccine. naïve network Neutralizing titer Patient Pfizer positive Predictive prospective observational study PROTECT RBD reached receiving Receptor binding domain reduce registry Responder responders SARS-CoV-2 severity Side effects significantly T-cell T-cell Response Tfh vaccinal vaccination Vaccine variable [DOI] 10.1016/j.kint.2021.10.040 PMC 바로가기 [Article Type] Observational Study
Antibody titers against the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 induced by BNT162b2 vaccination measured using automated chemiluminescent enzyme immunoassayBNT162b2 백신 접종으로 유도된 SARS-CoV-2의 알파, 베타, 감마 및 델타 변이체에 대한 항체가를 자동 화학발광 효소 면역분석법을 사용하여 측정했습니다.Article Published on 2022-02-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 50% neutralization titer acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting age AIA-CL Alpha analyzed Antibody titer automated Beta BNT162b2 BNT162b2 vaccine coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 Delta delta variant Delta variants dose enzyme enzyme immunoassay expected Factor female first dose Gamma healthcare worker Healthcare workers herd immunity Humoral immunity IgG IgG titer Immunity immunoassay Immunoglobulin Immunoglobulin G individual Japanese Laboratory Laboratory test Level measurement median neutralization neutralization titer neutralization titers Neutralizing titer of BNT162b2 Older Older age positive correlation proportions respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein subject vaccination variant Variant of concern. [DOI] 10.1016/j.jiac.2021.11.021 PMC 바로가기 [Article Type] Article
Longitudinal Immune Profiling of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection in a Solid Organ Transplant RecipientArticle Published on 2022-02-012022-11-15 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody caused CD4 T-cell cellular coronavirus coronavirus 2 coronavirus disease COVID-19 deficiency development Diagnosis Evidence Factor Genetic hospital Hospitalized humoral Humoral response immune escape mutations immune profiling Immunocompromised Immunocompromised patients Infection initial Lineage longitudinal male memory response neutralization titer Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing titer Patient performed Phylogenetic analysis Primary infection Profiling recipient reduction in Reinfection renal required respiratory SARS-CoV-2 SARS-COV-2 infection secondary infections Seropositivity Solid threshold Transplant transplant. Viral genome sequencing virus with COVID-19 [DOI] 10.1093/infdis/jiab553 PMC 바로가기