Many trials of hydroxychloroquine for SARS-CoV-2 were redundant and potentially unethical: an analysis of the NIH clinical trials registrySARS-CoV-2에 대한 하이드록시클로로퀸의 많은 시험은 중복되었고 잠재적으로 비윤리적이었습니다: NIH 임상 시험 레지스트리 분석Article Published on 2022-03-012022-09-11 Journal: Journal of clinical epidemiology [Category] SARS, 임상, 치료제, [키워드] Analysis appear benefit clinical clinical trial Clinical trial regulation clinical trials Community conducted COVID-19 Efficacy Equipoise Evidence evidence of HCQ Hydroxychloroquine lack landscape NIH offer pandemic Patient patient recruitment proportion Randomized controlled trials reason recommendation recommendations recruitment Registered registry Regulatory remained Research Ethics SARS-CoV-2 Suspension termination treat Trial [DOI] 10.1016/j.jclinepi.2021.11.011 PMC 바로가기 [Article Type] Article
Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and functionClinical Medicine Published on 2022-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, COVID19(2023년), SARS, [키워드] Acetate adaptive Adaptive immunity Affect anti-CD20 antibody Autoimmunity B cell CD19 CD4 CD8 cellular immunity characterized Clinical guidelines Cohort correlated COVID-19 cumulative cytokine expression Effect epitope foundation fumarate functional groups healthy control humoral IgG level Immunity Immunotherapy implication large cohort Luminex assay mAbs marker Multiple multiple sclerosis neutralization NIH participant Patient patients pseudovirus Quantitative reactivity receiving receptor reduced remained response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination spike Study participants T cell T cell response T cell responses therapy treated Treatment were assessed were measured [DOI] 10.1172/jci.insight.156978 PMC 바로가기 [Article Type] Clinical Medicine
The Effect of an After-School Physical Activity Program on Children’s Cognitive, Social, and Emotional Health during the COVID-19 Pandemic in Nova ScotiaArticle Published on 2022-02-192022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] activity Affect baseline Canada change children children’s health cognitive Cognitive function COVID-19 COVID-19 pandemic declined determine Effect emotional Follow-up Health Impact impacted limit measure NIH no significant difference Nova outcome parent physical activity positive Program programming PROMIS protective effect Psychological public health questionnaire recruited remained Satisfaction second wave Sleep disturbance Stress suggested System t-test variable were used [DOI] 10.3390/ijerph19042401 PMC 바로가기 [Article Type] Article
Trust in COVID-19 information sources and perceived risk among smokers: A nationally representative surveyResearch Article Published on 2022-01-272022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] addition association CDC COVID-19 COVID-19 disease severity COVID-19 susceptibility explain Factors FDA Gender groups Health independent information less media Multiple news media NIH outcomes Perceived risk Predictive professionals Public reduced risk researchers risk risk factor Risk perception risk perceptions severity smoker Smokers smoking Sociodemographic Trust [DOI] 10.1371/journal.pone.0262097 PMC 바로가기 [Article Type] Research Article
Pharmacokinetics of high-titer anti–SARS-CoV-2 human convalescent plasma in high-risk children고위험 소아에서 고역가 항-SARS-CoV-2 인간 회복기 혈장의 약동학Clinical Trial Published on 2022-01-252022-09-12 Journal: JCI Insight [Category] 임상, 진단, [키워드] age Analysis Anti-spike anti-Spike IgG antibody antibody kinetics antibody production Antibody titer Antibody titers appear characterized children convalescent plasma coronavirus COVID-19 declined develop disease Donor ELISA assays enrolled epitope Euroimmun evaluated expected exposure to funding IgG immunoglobulins Infectious disease Kinetics Kinetics of antibodies median age Mild Mild disease neutralization capacity neutralization titer neutralizing capacity NIH passive transfer performed pharmacokinetic pharmacokinetics plasma PROTECT receive recipient Research Safe SARS-CoV-2 Serious Adverse Event Serious Adverse Events severe disease Spike protein symptom onset transferred transfused transfusion Trial registration underlying condition underlying conditions unlikely virus neutralization assays weight while [DOI] 10.1172/jci.insight.151518 PMC 바로가기 [Article Type] Clinical Trial
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Diagnostic Performance of a Deep Learning Model Deployed at a National COVID-19 Screening Facility for Detection of Pneumonia on Frontal Chest RadiographsArticle Published on 2022-01-172022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] 95% confidence interval Algorithm Area artificial AUC average baseline calculated characteristic Chest radiograph COVID-19 COVID-19 pandemic CXR dataset datasets deep Degradation detect detection develop diagnostic facility Frontal hospital implementation initial input intelligence learning mass chest Model NIH performance Pneumonia positive provided Radiograph radiological radiologist reference standard Screening sensitivity specificity statistically significant the mean unique was reduced X-ray [DOI] 10.3390/healthcare10010175 PMC 바로가기 [Article Type] Article
CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1CRISPRi는 COVID-19 GWAS 유전자좌를 LZTFL1 및 RAVER1에 연결합니다.Article Published on 2022-01-062022-09-11 Journal: EBioMedicine [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activated Affect affected airway Analysis antiviral immune response antiviral response cell lines chromosome coactivator coding regions conducted COVID-19 COVID-19 disease COVID-19 disease severity CRISPRi Critical Critical illness dataset datasets disease severity epithelial cell epithelial cells exonic region expression finding funding Gene expression analysis Genes Genetic variant Genome-wide association studies Genome-wide association study GWAS highest Host humans ICAM1 identified variant identify IFIH1 indicated induce intron investigated loci locus lung lung epithelial lung epithelial cell Lung epithelial cells LZTFL1 MDA5 neighbouring genes NIH non-coding regions pathway RAVER1 Region regulated risk allele RNA-Seq significantly sn/scRNA-seq SNPs susceptible variant Viral viral clearance was performed weakened with COVID-19 [DOI] 10.1016/j.ebiom.2021.103806 PMC 바로가기 [Article Type] Article
A Systematic Review Assessing the Underrepresentation of Cancer Patients in COVID-19 TrialsArticle Published on 2022-01-012022-11-15 Journal: Acta haematologica [Category] SARS, 진단, [키워드] acute respiratory syndrome Assessing Cancer cancer patient cohort study Comorbidities coronavirus Coronavirus disease 2019 COVID-19 demonstrated disease Evidence excluded global pandemic hematological Hematological malignancy Immunosuppression inclusion criteria malignancy medication NIH outcome Patient patients Prophylactic Randomized controlled trial RCTs REGN-CoV2 Remdesivir reported review Seven severe acute respiratory syndrome coronavirus 2 solid cancer solid tumors Steroids systematic review therapeutic Tocilizumab treated Treatment Trial trials [DOI] 10.1159/000524623 PMC 바로가기
Antibody affinity maturation and cross-variant activity following SARS-CoV-2 mRNA vaccination: Impact of prior exposure and sexResearch paper Published on 2021-12-102022-11-01 Journal: EBioMedicine [Category] COVID-19, SARS, [키워드] Advancing Affinity maturation Alliance antibody antibody affinity Award binding center contribute convalescent convalescent individual convalescent individuals countermeasure COVID-19 Department described determine dose FDA female females finding funding Human Impact individual Infection Infectious disease initiative knowledge Limited male manuscript maturation mRNA mRNA vaccination mutant mutants naïve neutralization titer neutralizing antibody NIAID NIH no difference number Participants Plasmon prefusion profile Pseudovirus neutralization assay RBD Receptor binding domain resonance SARS-CoV-2 Science sera service Sex sex differences significantly higher SPR supported surface the SARS-CoV-2 university Vaccine vaccine dose variants variants of concern variants of interest Virus neutralization VOCs VOIs was used [DOI] 10.1016/j.ebiom.2021.103748 PMC 바로가기 [Article Type] Research paper