Management of COVID-19-induced cytokine storm by Keap1-Nrf2 system: a reviewKeap1-Nrf2 시스템에 의한 COVID-19 유발 사이토카인 폭풍 관리: 검토Review Published on 2021-10-012022-09-11 Journal: Inflammopharmacology [Category] Coronavirus, 유전자 메커니즘, [키워드] activate antioxidant antioxidants Biosynthesis boost CAP coronavirus disease Coronavirus disease 2019 COVID COVID-19 Cytokine storm Cytokines Defense defense mechanism Degradation erythroid cell facilitate Genes help homology in some inhibited Keap1 maintain mechanism Nrf2 nucleus pathway Protein protein complex released responsible stimulate Symptom the cytokine storm therapeutic use Travel [DOI] 10.1007/s10787-021-00860-5 PMC 바로가기 [Article Type] Review
Inhaled [D-Ala 2 ]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung InjuryResearch Article Published on 2021-09-272022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, [키워드] abrogate acute lung injury acute respiratory distress airway epithelial cell ARDS bind Box caused cellular chemokines COVID-19 Critical Cytokine storm Cytokines cytoplasm disease severity Effect endothelial cells enzyme expression Extracellular group HMGB1 HMGB1 release HMGB1 secretion identify immune cells Inflammatory Inflammatory mediators Inhaled inhibit life-threatening lung Lung diseases lysine mechanism of action mice Mobility Model modulation mouse nuclear nucleus occur peptide Pneumonia posttranslational modifications Proinflammatory cytokine Protein pulmonary inflammation RAGE receptors redox state Release released residue respiratory infection significantly SIRT1 syndrome the SARS-CoV-2 virus therapeutic TLR4 toll-like receptor 4 translocation treating COVID-19 Treatment [DOI] 10.1155/2021/4414544 PMC 바로가기 [Article Type] Research Article
Ultra- and micro-structural changes of respiratory tracts in SARS-CoV-2 infected Syrian hamstersSARS-COV-2 감염 시리아 햄스터에서 호흡기의 초소형 및 미세 구조적 변화Research Article Published on 2021-09-162022-09-10 Journal: Veterinary Research [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar alveolar epithelium alveoli animal models Bronchiole caused cellular change changes in Characteristics collected coronavirus cytoplasm cytoplasmic diminished disease electron eosinophil eosinophils epithelial euthanized groups hamster increasingly infancy inflammatory cell inflammatory cells information inoculated intranasally lamina propria lesion lesions Lower respiratory tract lung Lymphocytes macrophages margin Microscopic neutrophil Neutrophils nucleus on type organelle pandemic Particles pathological changes Post-infection pulmonary lesions PULMONARY VESSELS Research respiratory respiratory epithelium respiratory tract SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus susceptible therapy tissue tissues Trachea tracheal type 2 pneumocyte upper and lower respiratory tracts Vaccine vacuolation Vesicle vessels Viral virion [DOI] 10.1186/s13567-021-00988-w PMC 바로가기 [Article Type] Research Article
Concise Update on Genomics of COVID-19: Approach to Its latest Mutations, Escalated Contagiousness, and Vaccine ResistanceReview Article Published on 2021-09-152022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory distress Amino acid calreticulin canonical cause caused Cell changes in Chinese Clinical features complex connection coronavirus COVID-19 COVID-19 pandemic diagnostics Epidemiology genomic Genomics genomics of virus help histocompatibility complex Host hydrophobicity immune system Infectious disease inhibit intrinsic less membrane MHC-I Modification molecular multifunctional N-linked glycosylation Novel coronavirus novel coronavirus disease Nsp7 nucleus oligosaccharide outlined pandemic positive Protein proteomics Replication rate resistance response RNA genome SARS-CoV-2 sequence STAT structures syndrome transcription factor transfer translocated Treatment Vaccine development viral outbreak Viral protein virus [DOI] 10.1055/s-0041-1725143 PMC 바로가기 [Article Type] Review Article
A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFSNeurology Published on 2021-08-022022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] Activation affecting Characteristics chronic fatigue syndrom complex COVID-19 COVID-19 infection COVID-19 patient Critical disease dysfunction exceeded helping humoral hypothalamic paraventricular nucleus increasingly inflammatory mediator Inflammatory mediators intrinsic malaise ME/CFS Neuroinflammation neurological nucleus paradigm pathophysiological pathophysiology Pathways physiological Post-COVID Fatigue Syndrome proportion provided proximal released reported required SARS-CoV-2 stimulate Stressor stressors suggested susceptible Symptoms transmitted Trigger [DOI] 10.3389/fneur.2021.701419 PMC 바로가기 [Article Type] Neurology
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and ReplicationResearch Article Published on 2021-07-062022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affected Analysis caused complex coronavirus disease Coronavirus-2 cytoplasm demonstrated Direct RNA sequencing distribution evaluated expression function Host immunoprecipitation knockdown mechanism methylated RNA methyltransferase-like 3 METTL3 Modification modulate N6-methyladenosine nucleus overexpression pandemic plasmid transfection Protein RdRP reported respiratory respiratory syndrome coronavirus-2 RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 RNA Sequencing Transcriptome Viral protein viral replication Viral RNA [DOI] 10.1128/mBio.01067-21 PMC 바로가기 [Article Type] Research Article
The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease PathologyCell and Developmental Biology Published on 2021-06-252022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition Altered Alzheimer’s disease Alzheimer’s disease anatomical distribution angiotensin-converting enzyme 2 Brain brain region brain regions caused cells Central nervous system contribute coronavirus coronavirus disease COVID-19 COVID-19 patient downregulated Endothelial cell expressed expression level immunohistochemistry Invasion manifestation mapped Neurological symptom nucleus pandemic pathology protein level Research SARS-CoV-2 suggested [DOI] 10.3389/fcell.2021.684874 PMC 바로가기 [Article Type] Cell and Developmental Biology
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico EvidencesPharmacology Published on 2021-06-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Against anionic anti-inflammatory activity antiviral activity Bacterial bovine lactoferrin cationic Cell cells components Concentration COVID-19 COVID-19 patients demonstrated disorder DNA down-regulate exocrine gland feature Genes glycoprotein Host host cells Hypothesis IL-6 in silico in vitro in vitro assays Infection inflammation sites inhibiting involved Ion iron homeostasis lactoferrin management multiplicity of infection neutrophil nucleus observation performed Proinflammatory cytokine RNA S glycoprotein SARS-CoV-2 SARS-COV-2 infection secreted spike supported Vero viral entry viral replication virus [DOI] 10.3389/fphar.2021.666600 PMC 바로가기 [Article Type] Pharmacology
How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking SystemReview Published on 2021-06-072022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] antiviral drug Antiviral treatment clinical trial complex components dengue virus drug Ebola virus Epstein-Barr virus exportin Factor feasibility Hepatitis B virus Host Host immune response HS-AFM Human immunodeficiency virus human papillomavirus Importins influenza A involved NPC nuclear nuclear transport inhibitor nucleoporins nucleus Other receptor Replication route SARS-CoV-2 suppress System Transport viral nuclear export viral nuclear import virus viruses [DOI] 10.3390/cells10061424 PMC 바로가기 [Article Type] Review
Engineering of Chinese Hamster Ovary Cells With NDPK-A to Enhance DNA Nuclear Delivery Combined With EBNA1 Plasmid Maintenance Gives Improved Exogenous Transient Reporter, mAb and SARS-CoV-2 Spike Protein ExpressionBioengineering and Biotechnology Published on 2021-06-042022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] approach cell line characterisation Chinese Chinese hamster ovary cells CHO cells co-expression Combined complementary complex delivery dependent on Dilution DNA Efficiency element Engineering ENhance Epstein Barr Nuclear Antigen-1 Exogenous expressing Gene Expression glycoprotein growth hamster Improved initial mAb maintenance mammalian cell membranes NLS nuclear nuclear localisation signal nucleoside diphosphate kinase nucleus Ovary plasma Plasmid Protein reduce SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike time-consuming Transient transient expression transient gene expression utilised [DOI] 10.3389/fbioe.2021.679448 PMC 바로가기 [Article Type] Bioengineering and Biotechnology