Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19COVID19의 잠재적인 치료를 위한 정맥 코로나바이러스 3CL 프로테아제 억제제의 전임상 특성화Article Published on 2021-10-182022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 신약개발, 치료제, [키워드] 3CL ADME antiviral activity broad spectrum caused clinical development clinical evaluation Combination coronavirus COVID-19 COVID19 exhibited global pandemic Human human host in vitro in vivo inhibit inhibited inhibiting intravenous mice PF-07304814 Pharmacodynamics pharmacokinetics phosphate Potential treatment Preclinical Preclinical research prodrug protease Protease activity Protease inhibitor Protein Remdesivir safety profile SARS-CoV SARS-CoV-2 SARS-CoV-2 virus selectivity Support sustained targets the SARS-CoV-2 virus Treatment [DOI] 10.1038/s41467-021-26239-2 PMC 바로가기 [Article Type] Article
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporterArticle Published on 2021-08-202022-10-04 Journal: Nature Communications [Category] 변종, [키워드] bind binding binding pocket binding site Characteristics characterization characterized concentrations cryo-EM Cryoelectron microscopy depressive disorder exhibit Extracellular impede information inhibitor interacting residue Ligand Mental Molecular dynamics simulation molecular interaction molecular pharmacology Mutagenesis nanomolar affinity observé Pharmacodynamics Protein structure predictions resulting reveal selective Serotonin serotonin reuptake inhibitor Structural analysis structural biology target therapeutic Transport Transporters in the nervous system Treatment unique Vilazodone [DOI] 10.1038/s41467-021-25363-3 PMC 바로가기 [Article Type] Article
Liquid Chromatographic Methods for COVID-19 Drugs, Hydroxychloroquine and ChloroquineCOVID-19 약물, 하이드록시클로로퀸 및 클로로퀸에 대한 액체 크로마토그래피 방법Review Published on 2021-08-182022-09-11 Journal: Journal of chromatographic science [Category] SARS, 치료기술, 치료제, [키워드] 4-aminoquinoline Arthritis Autoimmune diseases biologic biological fluid biological fluids Chloroquine clinical trial clinical trials Complete country Course COVID-19 Determination doctor drug epidemiological studies facilitate HCQ Hydroxychloroquine information liquid lupus erythematosus malaria metabolite Patient pharmaceutical preparations Pharmacodynamics pharmacokinetics provide reported Research rheumatoid arthritis Safe supervision systemic lupus erythematosus Treatment treatment regimen [DOI] 10.1093/chromsci/bmaa110 PMC 바로가기 [Article Type] Review
Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic CharacteristicsReview Published on 2021-07-222023-07-01 Journal: International journal of nanomedicine [Category] SARS, [키워드] antiviral drug delivery systems metabolism Pharmacodynamics pharmacokinetics [DOI] 10.2147/IJN.S315705 PMC 바로가기 [Article Type] Review
Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotoninArticle Published on 2021-07-192022-10-04 Journal: Scientific Reports [Category] 신약개발, [키워드] acting affecting asked Brain brain region CA3 Cell cells Diseases of the nervous system ENhance expression female Fluoxetine had no heterozygous increase inhibition inhibitor loss-of-function mutation MECP2 mice motor Neurological disorders neuroscience patients Pharmacodynamics Pharmacology rare disease rescued Rett syndrome rodents selective Serotonin Symptom Transmission Treatment [DOI] 10.1038/s41598-021-94156-x PMC 바로가기 [Article Type] Article
Pharmacokinetics and pharmacodynamics of hydroxychloroquine in hospitalized patients with COVID-19COVID-19 입원 환자에서 하이드록시클로로퀸의 약동학 및 약력학Observational Study Published on 2021-07-012022-09-11 Journal: Thérapie [Category] SARS, 임상, 치료기술, [키워드] 95% confidence interval Administered Analysis Bioavailability C-reactive protein circulating clearance Concentration covariates COVID-19 COVID-19 patient COVID-19 patients daily dose distribution dosage dose e parameters effective elimination half-life estimate followed by half-life HCQ hospitalized patient hospitalized patients Hydroxychloroquine in vitro Inflammation inhibit intensive care units Liquid chromatography Loading doses Lupus median nasopharyngeal swabs Non-COVID-19 patients parameter Patient performed Pharmacodynamics pharmacokinetic pharmacokinetic analysis pharmacokinetic data pharmacokinetics plasma plasma concentration ranged reported required reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 patient severe COVID-19 patients tested Variability viral clearance Volume volume of distribution were measured with COVID-19 [DOI] 10.1016/j.therap.2021.01.056 PMC 바로가기 [Article Type] Observational Study
Patient-blood management for COVID19 convalescent plasma therapy: relevance of affinity and donor-recipient differences in concentration of neutralizing antibodiesCOVID19 회복기 혈장 치료를 위한 환자-혈액 관리: 중화항체 농도의 친화도 및 공여자-수혜자 차이의 관련성Review Published on 2021-07-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] MERS, 진단, [키워드] Affect affected antibody affinity Antibody testing CCP CCP therapy Clinical outcome clinical study clinical trial clinical trials Concentration convalescent plasma Coronavirus disease 2019 COVID-19 COVID19 disease dose Evidence immune evasion IMPROVE investigated lack majority management Neutralizing antibodies neutralizing antibody outcome Pharmacodynamics recipients risk searched stoichiometry Stoichiometry. Study design Treatment variable [DOI] 10.1016/j.cmi.2021.04.003 PMC 바로가기 [Article Type] Review
Investigating the interaction between nifedipine- and ritonavir-containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysisArticle Published on 2021-07-012023-07-13 Journal: British Journal of Clinical Pharmacology [Category] SARS, [키워드] drug-drug interaction Nifedipine Pharmacodynamics physiologically-based pharmacokinetic Ritonavir [DOI] 10.1111/bcp.14684
Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An updateCovid-19에서 논란의 여지가 있는 약물인 하이드록시클로로퀸에 대한 통찰력 탐색: 업데이트Review Published on 2021-05-012022-09-11 Journal: Food and chemical toxicology : an international jo [Category] 신약개발, 치료제, [키워드] analysed article Asymptomatic Chloroquine clinical clinical trial conducted COVID-19 COVID-19 patients Efficacy extreme HCQ health worker higher risk Hydroxychloroquine include management mechanism Mild mild symptoms Neutral pandemic parameter Patient Pharmacodynamics pharmacokinetic pharmacokinetics Prophylactic regimen reported Research SARS-CoV-2 SARS-CoV-2 pandemic stages Symptoms the SARS-CoV-2 Toxicity Treatment Trial utility [DOI] 10.1016/j.fct.2021.112106 PMC 바로가기 [Article Type] Review
Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria피페라퀸의 반기계적 약리학적 및 약동학적 모델링: 플라스모디움 팔시파룸 혈액 단계 말라리아 자원봉사자 감염 연구Article Published on 2021-01-192024-08-08 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial agents Controlled human malaria infection Induced blood-stage malaria P. falciparum malaria Pharmacodynamics pharmacokinetics Pharmacology Piperaquine Population pharmacokinetics [DOI] 10.1128/AAC.01583-20 PMC 바로가기