Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 ReplicationArticle Published on 2020-08-112023-07-02 Journal: Molecular Cell [Category] SARS, [키워드] COVID-19 Drug repurposing Phosphoproteomics PI3K proteomics RAS SARS-CoV-2 Signaling TMT viral replication [DOI] 10.1016/j.molcel.2020.08.006 PMC 바로가기
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infectionROS 매개 PI3K 활성화는 감염에 대한 반응으로 기질 세포에서 조혈모세포로의 미토콘드리아 이동을 유도한다.Article Published on 2019-12-032024-08-21 Journal: Microbial Cell Factories [Category] 살모넬라증, [키워드] Hematopoietic stem cell Infection Mitochondria PI3K ROS
Pharmacotherapy of relapsed/refractory chronic lymphocytic leukemiaArticle Published on 2018-12-232024-09-04 Journal: Expert opinion on pharmacotherapy [Category] 대상포진, [키워드] B-cell receptor BCl2 BTK Chemoimmunotherapy CLL Ibrutinib Idelalisib PI3K rational combinations venetoclax [DOI] 10.1080/14656566.2017.1324420 PMC 바로가기 [Article Type] Article
Future therapeutic targets in rheumatoid arthritis?Review Published on 2017-04-272024-09-02 Journal: Seminars in immunopathology [Category] 대상포진, [키워드] BTK GM-CSF Jak PI3K rheumatoid arthritis tolerogenic dendritic cells [DOI] 10.1007/s00281-017-0623-3 PMC 바로가기 [Article Type] Review
DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNKarticle Published on 2017-03-312024-09-01 Journal: Molecular Immunology [Category] 폐렴구균 감염증, [키워드] DNAJ IL-6 JNK PI3K Streptococcus pneumoniae [Article Type] article
Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β PathwayResearch Article Published on 2016-08-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activated caused cellular pathway downstream effector epidemic diarrhea function high mortality Infection inhibiting intracellular signaling late stage pathway Pathways PEDV phosphatidylinositol 3-kinase PI3K regulated Replication required shown signaling pathway subsequent suppression upstream Vero Cell Vero cells viral infection virus virus replication [DOI] 10.1371/journal.pone.0161508 PMC 바로가기 [Article Type] Research Article
Induction of Central Host Signaling Kinases during Pneumococcal Infection of Human THP-1 Cells폐렴구균 감염 중 인간 THP-1 세포에서 중앙 숙주 신호 전달 키나제의 유도Original Research Published on 2016-04-262024-08-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] AKT Cell signaling ERK1/2 p38 phagocytosis PI3K Streptococcus pneumoniae THP-1 cells [DOI] 10.3389/fcimb.2016.00048 PMC 바로가기 [Article Type] Original Research
The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cellsResearch Paper: Immunology Published on 2016-03-152022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] Actin activating binding cascade cause cell membrane cofilin coronavirus decrease diarrhea disrupt downstream EGFR epidermal F-actin gastroenteritis growth factor GTPases high mortality Host immune response Immunity Immunology and Microbiology Section Infection inhibit inhibition intestinal epithelial cell intestinal epithelium involved MAPK mechanism Newborn Pathogenesis Phosphorylation PI3K platform promote Protein receptor regulate responsible Signaling signaling pathway Spike protein stimulate TGEV transmissible gastroenteritis virus upstream virus entry [DOI] 10.18632/oncotarget.7723 PMC 바로가기 [Article Type] Research Paper: Immunology
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article
Comparison of influenza virus yields and apoptosis-induction in an adherent and a suspension MDCK cell lineArticle Published on 2013-11-192023-06-24 Journal: Vaccine [Category] 신종인플루엔자, [키워드] 1:2 dilution at toi 1:2dil 50% tissue culture infective dose A/PR/8 A/Puerto Rico/8/34 carcinoembryonic antigen-related cell adhesion molecule 6 CEACAM6 EMA European Medicines Agency FDA FITC flow cytometry fluorescein isothiocyanate Food and Drug Administration Glasgow minimum essential medium GMEM HA Haemagglutinin hours post infection hpi Influenza MAD Madin–Darby canine kidney MDCK MDCK suspension cells median of absolute deviation Medium exchange MOI multiplicity of infection phosphatidylinositide 3-kinase PI3K TCID(50) TdT dUTP nick end labelling time of infection toi Trypsin activity TUNEL Vaccine w/oME with medium exchange without medium exchange. wME [DOI] 10.1016/j.vaccine.2013.09.051