Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)article Published on 2023-07-242024-09-05 Journal: Journal of Enzyme Inhibition and Medicinal Chemistry [Category] update2024, [키워드] AKT Anticancer therapy inhibitors PI3K PIKK [DOI] 10.1080/14756366.2023.2237209 PMC 바로가기 [Article Type] article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance Research Published on 2022-07-232022-10-05 Journal: Communications Biology [Category] 변종, [키워드] analyses applied blockade blocker blockers docking Effect endolysosomal endomembrane facilitate histidine Human IC50 identify inhibit inhibitor inhibitors interact Kinase inhibitor kinase inhibitors mechanism molecular mutant pharmacological PI3K PIKfyve inhibitor residue sensitivity Substitution [DOI] 10.1038/s42003-022-03701-5 [Article Type] Research
Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2네트워크 약리학 및 분자 도킹은 SARS-Cov-2로 인한 폐렴 치료에서 허브 호우 트 튜 니아 코타 타의 근본적인 약리학 적 메커니즘을 설명합니다.Article Published on 2022-07-212022-08-31 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity afzelin Analysis antiviral properties apigenin applied approach Asian caused China Combination docking DPP4 ELANE expression profiling Factor Herb herbal medicine High-throughput sequencing Houttuynia cordata HSP90AA1 IL6 ingredient integration involved Jak-STAT Japan kaempferol MAPK MAPK1 mechanism metabolite molecular molecular docking molecular dynamics Molecular dynamics simulation network network pharmacology NF-kB pharmacological pharmacological mechanism Pharmacology PI3K Pneumonia provide pulmonary infections quercetin reported required Research SARS-CoV-2 Sequencing SERPINE1 signaling pathways STAT suggested systemic level target therapeutic therapeutic effect therapeutic potential therapy treat treating [DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment증례 보고: SARS-CoV-2 감염이 오래 지속된 APDS 환자 1명에서 단일클론항체로 성공적인 치료Case Reports Published on 2022-06-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activated activated PI3K delta syndrome (APDS) administration affected APDS clearance COVID19 described Efficacy first positive genotyping IEI Infection LINE long-lasting long-lasting infection monoclonal monoclonal antibodies monoclonal antibody multiple therapeutic agent multiple therapeutic agents neutralizing monoclonal antibodies other treatments Patient pauci-symptomatic PI3K Prolonged reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Swab syndrome tested the SARS-CoV-2 virus therapeutic agents Tolerability treated Viral viral shedding virus wild type [DOI] 10.3389/fimmu.2022.891274 PMC 바로가기 [Article Type] Case Reports
Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathySARS-CoV-2 유도 응고병증에서 PI3K/AKT 신호전달 경로의 가능한 역할 및 치료 가능성Review Published on 2022-01-112022-09-10 Journal: Cellular & Molecular Biology Letters [Category] 치료기술, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alteration ARDS association caused Cell cell survival cellular pathway Coagulation coagulation factor Coagulation factors Coagulopathies Coagulopathy Complication complications coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients cytokine Cytokine storm death disease Evidence followed by high mortality rate involved majority molecular mechanism pathologic process pathway patients with COVID-19 PI3K PI3K/AKT respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus signaling pathway survival syndrome therapeutic potential therapeutic target [DOI] 10.1186/s11658-022-00308-w PMC 바로가기 [Article Type] Review
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicineSARS-CoV-2 계통 중 Omicron N501Y 돌연변이: 티로신 키나아제 및 가상의 용도 변경 의약품에 대한 강력한 결합의 인실리코 분석Article Published on 2022-01-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 신약개발, [키워드] Analysis analyzed applied B.1.1.7 B.1.351 binding Cancer Cancer patients Care EGFR elevated ENhance enrichment Factor host cell host cells hypothetical Interaction kinase kinases Lineage lineages management molecular docking analysis Mutation N501Y N501Y mutation network network pharmacology omicron pandemic pathogenic Pathways Phosphorylation PI3K polar Precision predicted Receptor binding domain SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 lineage Signaling Spike receptor binding domain therapy tyrosine variants [DOI] 10.1016/j.tmaid.2021.102242 PMC 바로가기 [Article Type] Article
Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking네트워크 약리학 및 분자 도킹을 기반으로 Covid-19에 대한 수 헥치 안약의 잠재적 메커니즘 탐색4200 Published on 2021-12-232022-08-31 Journal: Medicine [Category] 유전자 메커니즘, 치료제, [키워드] activator Analysis Anti-viral applied AutoDock binding affinity biological processe cells chemokine Chinese classic collected Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease Cytokine storm Cytoscape software database Diagnosis disease endothelial epidermal epidermal growth factor Functional enrichment analysis GeneCard Genes growth factor guideline hub genes hypoxia immune function immune system include inflammatory storm ingredient interleukin interleukin 17 interleukin 6 Intersection janus Janus kinase KEGG Kyoto mechanism moderate molecular docking molecular mechanism Necrosis network pharmacology Ontology pathway enrichment Pathways phosphatidylinositol phosphatidylinositol 3-kinase PI3K pill plague platform potential mechanism potential therapeutic targets predicted Protein kinase B protein-protein interaction R language receptor Regulation screened severe COVID-19 signaling pathways STAT3 suggested suhexiang pill synergistic T cell T cell receptor target target gene Target genes targets TNF Traditional Chinese medicine Transcription Treatment Tumor tumor necrosis tumor necrosis factor Vascular Viral viral invasion was used [DOI] 10.1097/MD.0000000000027112 PMC 바로가기 [Article Type] 4200
Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19생물 정보학 및 실리코 내 발견은 결장 직장암 및 Covid-19에 대한 바이오 카닌 A의 의학적 특징과 약리학 적 목표를 보여줍니다.Research Article Published on 2021-12-232022-09-01 Journal: Bioengineered [Category] 유전자 메커니즘, 진단, 치료제, [키워드] addition Analysis applied approach biochanin a bioinformatics biological function Cancer patients CCND1 cell proliferation Chronic diseases Clinical use Cluster Colorectal cancer combination therapy COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cytokine receptor demonstrated Effect effective EGFR feature functional gene cluster IL1A IL2 IL6R immune response in-silico Interaction interleukin-6 involved JAK-STAT signaling pathway lack Mortality network pharmacology pathology Pathway analysis Patient patients pharmaceutical target pharmacological target PI3K PPARG receptor Side effect STAT therapeutic option Treatment [DOI] 10.1080/21655979.2021.2005876 PMC 바로가기 [Article Type] Research Article