Endomembrane targeting of human OAS1 p46 augments antiviral activity인간 OAS1 p46의 내막 표적화는 항바이러스 활성을 증가시킵니다Research Article Published on 2021-08-032022-09-10 Journal: eLife [Category] MERS, SARS, 치료기술, 치료제, [키워드] Antiviral antiviral activity cellular COVID-19 COVID-19 severity cytosol detect endomembrane endomembrane system ENhance genetic analysis highlight Host Human Infection innate immune sensors Innate immunity interferon stimulated genes isoform membrane OAS1 organelle picornaviruses positioned replicate Replication responsible RNA RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 replication severe COVID-19 SNP specificity subset targeting Viral viral product viral products viral replication Viral RNA virus viruses [DOI] 10.7554/eLife.71047 PMC 바로가기 [Article Type] Research Article
Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning약물 디자인 및 재배치 촉진을 위한 수화된 바이러스 이온 채널의 리간드 결합 모드 결정Article Published on 2021-07-272022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] amantadine antiviral drug atomic resolution binding bridging interaction build candidate capture channel complex complex structure complexes COVID-19 pandemic derivative Determination determined by Diversity drug drug candidate drug design Drug discovery envelope protein experiment foster help hydrocarbon hydrophobic IMPROVE Influenza influenza A investigated Ion ion channel ion channels Ligand mechanism of action mode Numerous positioned protocol Region reliability repositioning resulting SARS-CoV-2 scratch Structure structures the SARS-CoV-2 transmembrane Undetermined water water molecules waters while [DOI] 10.1021/acs.jcim.1c00488 PMC 바로가기 [Article Type] Article
Current Status of Baricitinib as a Repurposed Therapy for COVID-19Review Published on 2021-07-152022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Baricitinib benefit bioinformatics changed Clinical practice clinical trial clinical trials Combination COVID-19 COVID-19 pandemic COVID-19 patients current cytokine drug drug candidates drug design evaluate Final Gene Expression highlight information inhibitor initial jak inhibitors knowledge Mortality pharmacological positioned Remdesivir Repository SARS-CoV2 status suggested transcriptomics Treatment [DOI] 10.3390/ph14070680 PMC 바로가기 [Article Type] Review
Primary care teams’ experiences of delivering mental health care during the COVID-19 pandemic: a qualitative studyResearch Published on 2021-07-012022-10-28 Journal: BMC Family Practice [Category] Coronavirus, SARS, [키워드] affected analysed arising Canada Care conducted COVID-19 COVID-19 pandemic Critical ENhance focus group later phase mental health mental health care pandemic Participants patients positioned primary care Qualitative Result rising supplementary material Support thematic analysis understanding Virtual care [DOI] 10.1186/s12875-021-01496-8 PMC 바로가기 [Article Type] Research
Methodology for Addressing Infectious Aerosol Persistence in Real-Time Using Sensor NetworkCommunication Published on 2021-06-072022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, MERS, SARS, [키워드] aerosol Aerosols Air quality average clinics Combination Concentration conducted COVID-19 decrease dental clinics dentistry develop Device Dispersion modeling Effectiveness equipment exposure assessment extra-oral suction device extraoral fixed generate HEPA high-volume evacuation Human IMPROVE infection control Influenza Intervention Local MOST network operator pandemic Particle particle concentration Particles persistence positioned provide risk School sensor sensor network tested Transmission transmission of disease Tuberculosis University of Washington was used [DOI] 10.3390/s21113928 PMC 바로가기 [Article Type] Communication
Peripheral and lung resident memory T cell responses against SARS-CoV-2SARS-CoV-2에 대한 말초 및 폐 상주 기억 T 세포 반응Article Published on 2021-05-212022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute infection Anti-inflammatory Antiviral antiviral response Apoptosis apoptotic Biopsy material Blood CCR7 Cell cellular immunity circulating Clinical outcome Convalescent patients COVID-19 Cytokines degranulation disease severity functional highlight identify IFNγ IL-10 IL-12p70 IL-4 IL-4 responses Infection Infectious diseases initial limit lung lung biopsy lung parenchyma Lungs memory T memory T cell memory T cells modulated Mucosal immunology outcome Patient patients with COVID-19 peptide peptides peripheral persistence positioned profiles reduce Reinfection required resident respiratory respiratory tract response responses against SARS-CoV-2 SARS-COV-2 infection secreting severity Spread T cell T cell response T cell responses T cells these cell These cells Viral viral infection Viral protein Viral proteins virus-specific T cell window [DOI] 10.1038/s41467-021-23333-3 PMC 바로가기 [Article Type] Article
COVID-19 pandemic experiences of parents caring for children with oesophageal atresia/tracheo-oesophageal fistulaPatient Perspective Published on 2021-05-182022-10-28 Journal: BMJ Paediatrics Open [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] Analysis Anxiety approach Care children Community COVID-19 COVID-19 pandemic Delay demonstrated described developmental disease employment Escalation evaluated Future Health healthcare healthcare service impacts information Inpatient Isolation limitations magnitude measure pandemic parent parental parents participant Participants Patient positioned positive qualitative research Rapid reported Result risk Safe Support thematic analysis [DOI] 10.1136/bmjpo-2021-001077 PMC 바로가기 [Article Type] Patient Perspective
Guidelines for Reopening a Nation in a SARS-CoV-2 Pandemic: A Path ForwardArticle Published on 2021-05-142022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] Action acute respiratory syndrome air filtration benefit breadth Care chronic illnesses conditions coronavirus COVID-19 creating death described diagnoses disease exacerbated expected filtration Forward Government guideline guidelines hand washing healthcare hygiene implementation inactivation Infection Infectious disease Intervention involved Local magnitude management Masks material mental health condition morbidity morbidity and mortality nation National objective pandemic path Patient personal protective filtering devices physician Physicians positioned Protective public health reduce reduction in reopening Replication required Result resulting review risk routine care SARS-CoV-2 SARS-COV-2 infection social distancing social interaction Therapies vaccination Vaccines Ventilation Viral load viral particle virus was selected [DOI] 10.3390/medicina57050496 PMC 바로가기 [Article Type] Article
Mouth-nose masks impair the visual field of healthy eyesResearch Article Published on 2021-05-132022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] acute respiratory syndrome analysed calculated condition Coronavirus-2 defined eye eyelid healthy impair Mask perimetry positioned Prevent recruited Result SARS-CoV-2 sensitivity significantly subject Transmission Visual field was done [DOI] 10.1371/journal.pone.0251201 PMC 바로가기 [Article Type] Research Article
Characterization of the SARS-CoV-2 coronavirus X4-like accessory proteinResearch Published on 2021-05-082022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] Analysis bat characterization characterized conserved coronavirus COVID-19 database Evidence experiment good quality Health identity in vitro in vivo indicate information MolProbity mutate novel coronavirus SARS-CoV-2 positioned Protein provide Region Result robust SARS-CoV SARS-CoV-2 Support the SARS-CoV-2 Therapeutics Vaccine virus viruses was obtained X4 protein Z score [DOI] 10.1186/s43042-021-00160-1 PMC 바로가기 [Article Type] Research