Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19한의학 치료가 코로나19 회복기에 미치는 임상적 특징과 영향Research Paper Published on 2021-01-012022-08-31 Journal: International Journal of Medical Sciences [Category] MERS, 치료제, [키워드] albumin analyzed blood cell Characteristics China Chinese clinical Clinical data clinically Coagulation convalescent COVID-19 COVID-19 patient COVID-19 patients discharged discharged patient discharged patients examined function heart Hematopoiesis hemoglobin immune response Impact interleukin-6 laboratory examination lipid metabolism liver mechanism medical observation observation Platelet Platelet count potential molecular prealbumin procalcitonin proportion randomized trial red blood cell Retrospective analysis serum Shenzhen significantly suggested Symptoms TCM Traditional Chinese medicine transpeptidase Treatment White blood cell white blood cell count [DOI] 10.7150/ijms.52664 PMC 바로가기 [Article Type] Research Paper
Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patientsResearch Article Published on 2020-12-212022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] blood cell bronchoalveolar Cell cells cellular cellular response characterized clinical manifestations COVID-19 COVID-19 patient COVID-19 severity Critically ill CXCL8 CXCR1 CXCR2 event events explain Express expressed expression FIVE GAPDH Genes HIF1α hypoxia immature immature myeloid cells Immunopathogenesis Increased Inflammation involved leukocyte lung cell marker metabolism molecular monocyte monocyte-macrophages Monocytes mRNA myeloid cell Neutrophils oxygen levels performed peripheral blood cells PFKFB3 PGK1 physiological response potential molecular precursors regulated Result RNAseq SARS-CoV-2 scRNAseq severe cases SLC2A3 SOD2 subset target targets therapy TLR TLR2 transcription factor transcriptional transcriptionally virus [DOI] 10.1080/07853890.2020.1858234 PMC 바로가기 [Article Type] Research Article
Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin푸에라린의 항 코로나 바이러스 질병 2019 (COVID-19) 표적 및 메커니즘Original Article Published on 2020-11-262022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] Apoptosis B cell BCl2 binding CASP3 CASP8 caspase caspase 3 caspase 8 Cell COVID‐19 COVID‐19 disease docking effective EGFR epidermal epidermal growth factor FOS growth factor IL2 in silico inflammatory cascades interleukin interleukin 2 MAPK marker mechanism methodology modulation molecular docking molecular markers Necrosis network pharmacology nitric oxide nitric oxide synthase NOS3 oxidative stress p53 pathway Pathways pharmacological potential molecular Potential treatment PPARG PRKCA PRKCB Protein protein kinase protein p53 PTGS2 puerarin receptor RELA suppression target targets TNF TP53 treat Treatment tumour necrosis factor [DOI] 10.1111/jcmm.16117 PMC 바로가기 [Article Type] Original Article
The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 AgentsReview Published on 2020-09-072022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] agent anti-SARS-CoV-2 application article assist bioinformatics caused Community Comprehensive contribute coronavirus disease Drug discovery Genetic health system Infection Infectious disease Innate immunity involved modeling molecular molecular mechanism Molecular modeling New New coronavirus outbreak pandemic Pathogenesis Potential potential molecular potential therapeutic target provided rapid expansion researcher responsible review SARS-CoV-2 SARS-CoV2 seeking Sequencing Spread Structure target targets the disease the SARS-CoV-2 therapeutic targets Treatment virulence WHO World Health Organization [DOI] 10.3390/molecules25184086 PMC 바로가기 [Article Type] Review
Obesity and COVID-19: Molecular Mechanisms Linking Both PandemicsReview Published on 2020-08-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] acute respiratory syndrome addition addressed adipose adipose-derived mesenchymal stem/stromal cells administration airway epithelial cell anti-inflammatory cytokine Cell characteristic chronic inflammation clearance combating Comorbidities contribute contributing to coronavirus coronavirus disease correlation COVID-19 COVID-19 disease COVID-19 pandemic Cytokine storm deregulated Endothelium Evidence functional Hospitalization immune modulatory immune response impair Increasing individual Inflammation lung Measures mechanism metabolic dysfunction molecular mechanism Mortality Motile cilia obesity outcome overexpress pathogenesis of COVID-19 Patient potential molecular protease Protective public health crisis pulmonary fibrosis receptor reducing SARS-CoV-2 severe COVID-19 severity stem cell systemic inflammation the cytokine storm the SARS-CoV-2 therapy tissue virus [DOI] 10.3390/ijms21165793 PMC 바로가기 [Article Type] Review
Potential mechanism prediction of Cold-Damp Plague Formula against COVID-19 via network pharmacology analysis and molecular dockingResearch Published on 2020-07-302022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] ACE2 activities analyses Analysis Anti-inflammatory Anti-inflammatory effects Anti-viral approach binding Blood cellular response circulation Cluster Cold‒Damp Plague Formula (CDPF) component components Compound COVID-19 database demonstrated disease docking drug-likeness effective Formula functional annotation Gene ontology global public health GO enrichment analysis host cells identify IL6 immune regulation ingredient Interaction KEGG KEGG pathway analysis Kyoto mechanism mechanism of action molecular molecular docking molecular mechanism network pharmacology oral bioavailability pathway pharmacological Potential potential molecular PPI PPI network predict provide provided receptor Regulation Result SARS-CoV-2 selected target targets Therapeutic benefit treat Treatment Version was used [DOI] 10.1186/s13020-020-00360-8 PMC 바로가기 [Article Type] Research
A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2Review Published on 2020-07-252022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acute respiratory syndrome autophagy caused Cell complications coronavirus coronavirus disease COVID-19 COVID-19 patients Cytokine storm Defense Evidence expression global public health Human immune defense immune response immunomodulatory Infection interferon type III mechanism mechanisms message miRNA mitigate modulation mother Neonatal COVID-19 NF-κB pathway nuclear occur outbreak pandemic pathogen pathology pathway physical physical barrier Placenta placental potential molecular Pregnancy pregnant women preterm births Proteases receptor reducing SARS-CoV-2 SARS-CoV-2 transmission Signaling Stillbirth the interferon These data tissue Transmission type III vertical transmission viral infections Virus-host interaction [DOI] 10.3390/cells9081777 PMC 바로가기 [Article Type] Review
Characteristics of the Coronavirus Disease 2019 and related Therapeutic OptionsArticle Published on 2020-06-242022-10-30 Journal: Molecular Therapy [Category] COVID-19, [키워드] acute respiratory syndrome affecting cause caused Characteristics Clinical symptoms clinical trial coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients death rate Diagnosis effective feature Genome global pandemic Incubation period Infection molecular target option patients Pneumonia potential molecular provide Replication resulting SARS-CoV-2 SARS-COV-2 infection severe health problem suppress target therapeutic drug Treatment Vaccine development [DOI] 10.1016/j.omtm.2020.06.013 PMC 바로가기 [Article Type] Article